Gene Information

Name : ureC (BP3168)
Accession : NP_881730.1
Strain : Bordetella pertussis Tohama I
Genome accession: NC_002929
Putative virulence/resistance : Virulence
Product : urease subunit alpha
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0804
EC number : 3.5.1.5
Position : 3380838 - 3382553 bp
Length : 1716 bp
Strand : -
Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alp

DNA sequence :
ATGACCAGGATTTCGCGTTCGGCATATGCCGAGATTTACGGGCCGACCGTGGTCGGCGGCGTCGGCGACCGGGTGCGCCT
GGCCGACACGCTGCTGCTGGCCGAGGTCGAGAAGGACCACACCATCTTCGGCGAGGAGGTGAAGTTCGGCGGCGGCAAGG
TCATCCGCGACGGCATGGGGCAGAGCCAGCGCCTGGCCACCGATTGCGTCGACACGGTGATCACCAACGCGCTGATCATC
GACGCGGTGACCGGCATCGTCAAGGCCGACATCGGCATCAAGGACGGGCTGATCAGCGGCATCGGCAAGGCGGGCAACCC
GGACACCCAGCCGGGCGTGACCATCATCATCGGCGCTTCGACCGAGGTGGTGGCCGGCGAGGGGCTGATCGTGACGGCCG
GCGCCATCGATACGCATATCCACTTCATCTGTCCGCAGCAGATCGAGGAGGCCCTGGCCACCGGCACGACCACCATGATA
GGCGGCGGCACCGGGCCGGCCACCGGATCGCTGGCCACCACCAGCACCTCGGGCCCCTGGCACATGGCCGCCATGCTGCA
GGCGCTGGACGCCTTTCCGGTGAACGTGGGCCTGTTCGGCAAGGGCAGTTCGAGCTCGCACGGCGCGCTGCTGGAGCAGG
TGCGGGCCGGCGCCATGGGCCTGAAGATCCACGAGGACTGGGCCAGCACGCCGGCTTCCATCGATACCTGCCTGAACGTG
GCCGAGGAAACCGACATCCAGGTCGCGATCCACAGCGACACGCTCAACGAGTCGGGCTTCGTGGAGGACACGTTCGCCGC
GTTCAAGGGCCGCACCATCCATTCCTTCCATACGGAAGGCGCCGGCGGCGGCCACGCGCCGGACATCATCCGGGCCGCCG
GCATGCCCAACGTGCTGCCGGCCTCGACCAACCCGACCATGCCGTTCACGCGCAACACGATCGACGAGCACCTGGACATG
GTCATGGTGTGCCATCACCTGGATCCATCCATCGCCGAGGACCTGGCTTTCGCCGAAAGCCGGATCCGGCGCGAGACCAT
CGCGGCCGAGGACATCCTGCACGACCTGGGGGCGTTCTCCATCATGAGCTCGGACTCGCAGGCCATGGGGCGCGTGGGCG
AGATCGTCCTGCGCACCTGGCAGACCGCGCACAAGATGAAGCTGCAGCGCGGCCCGCTGCAAGGCGACAGCGAGCGCTCG
GACAATGAGCGCATCAAGCGCTACATCGCCAAGTACACCATCAACCCGGCCGTGGCGCATGGCATCGCGCACCTGGTGGG
CTCGGTGGAAGTGGGCAAGCTGGCCGACCTGGTGCTGTGGAAGCCCGCCTTTTTCGGCGTCAAGGTCAACATGGTGCTCA
AGAGCGGCATGGCCGTCAGCGCCAGCATCGGCGACATGGGCGCCTCGATCTCGACGCCGCAGCCGGTGCAGATCCGCCCC
ATGTGGGGCAGCCACGGCAAGGCGCTGCGCACCTCGGTGGCCTTCGTCTCGCAGGTCAGCCTGAGCAATCCGGCGGTCAG
CGAACTGGGGCTGAACAAGCGCCTGGAGGCGGTGCGCGGATGCCGCGGCGTGACCAAGCACGACATGGTGCGCAACAACT
GGCTGCCGGCGATCTCGGTCGACCCGCAGACCTACCAAGTCTATGCCGATGGGCAATTGCTCAGATGCGAGGCGCTTGCC
GAGCTGCCCATGGCGCAACGCTATTTCCTGTTCTGA

Protein sequence :
MTRISRSAYAEIYGPTVVGGVGDRVRLADTLLLAEVEKDHTIFGEEVKFGGGKVIRDGMGQSQRLATDCVDTVITNALII
DAVTGIVKADIGIKDGLISGIGKAGNPDTQPGVTIIIGASTEVVAGEGLIVTAGAIDTHIHFICPQQIEEALATGTTTMI
GGGTGPATGSLATTSTSGPWHMAAMLQALDAFPVNVGLFGKGSSSSHGALLEQVRAGAMGLKIHEDWASTPASIDTCLNV
AEETDIQVAIHSDTLNESGFVEDTFAAFKGRTIHSFHTEGAGGGHAPDIIRAAGMPNVLPASTNPTMPFTRNTIDEHLDM
VMVCHHLDPSIAEDLAFAESRIRRETIAAEDILHDLGAFSIMSSDSQAMGRVGEIVLRTWQTAHKMKLQRGPLQGDSERS
DNERIKRYIAKYTINPAVAHGIAHLVGSVEVGKLADLVLWKPAFFGVKVNMVLKSGMAVSASIGDMGASISTPQPVQIRP
MWGSHGKALRTSVAFVSQVSLSNPAVSELGLNKRLEAVRGCRGVTKHDMVRNNWLPAISVDPQTYQVYADGQLLRCEALA
ELPMAQRYFLF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ureC NP_286680.1 urease subunit alpha Virulence TAI Protein 3e-170 67
ureC NP_287088.1 urease subunit alpha Not tested TAI Protein 3e-170 67
ureC YP_005684266.1 Urease alpha subunit Not tested PiCp 7 Protein 2e-158 61
ureC YP_005682174.1 Urease alpha subunit Not tested PiCp 7 Protein 3e-158 61
ureC YP_003784325.1 urease subunit alpha Not tested PiCp 7 Protein 3e-158 61
ureC YP_005686358.1 Urease alpha subunit Not tested PiCp 7 Protein 3e-158 61

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
ureC NP_881730.1 urease subunit alpha VFG0270 Protein 2e-143 59