Gene Information

Name : guaA (BB2327)
Accession : NP_888870.1
Strain : Bordetella bronchiseptica RB50
Genome accession: NC_002927
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 2479038 - 2480630 bp
Length : 1593 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGCACCAGCGCATCCTCATTCTTGACTACGGTTCGCAAGTCACCCAGCTGATCGCCCGCCGCGTCCGCGAAGCCGGCGT
CTACTCCGAAATCCACGCCGGCGACGTCGACGACGCCTTCGTGCGCGACCAGGTCGCGCAGGGCCTCAAAGGCATCATCC
TCTCGGGCAGCCACGCATCGGCCTACGAAGAGGGCTCGATGCGCGTGCCGGCGGCCGTGTTCGAAGTCGGCGTGCCCGTG
CTGGGCATCTGCTACGGCATGCAATCCATGGCCCAGCAACTGGGCGGCACCGTCAGCTTCAGCGACCACCGCGAATTCGG
CTACGCCGAAGTGCGCGCCCATGGCCACACCAAACTGCTCGACGGCTTGGCCGACTTCACCACCGACGAAGGCCACGGCA
TGCTCAAGGTGTGGATGAGCCATGGCGACAAAGTCACCGAACTGCCGCCGGGCTTCAAGCTGATGGCCTCCACCGCCTCC
TGCCCCATCGCCGGCATGGCCGACGAGGATCGTGGCTTCTACGCCGTGCAGTTCCACCCCGAAGTCACCCACACCGTCCA
GGGCAAGGCCATGCTGGCGCGCTTCGTCAAGGACATCTGCGGCTGCGAGGGCGACTGGAACATGCCCGACTACATCTCGG
AAGCGGTCGCCCGCATCCGCGAACAGGTCGGCAGCGACGAAGTCATCCTCGGCCTGTCCGGCGGCGTGGACTCCTCGGTG
GCCGCCGCGCTCATTCACCGCGCCATCGGCGACCAGCTCACCTGCGTCTTCGTCGACCACGGCCTGCTGCGCCTGGACGA
AGGCAAACAGGTCATGCAGACCTTCGCCGAGAACATGGGCGTCAAGATCGTCCATGTCGACGCCACCAGCCAGTTCATGG
GCAAGCTGACCGGCGTCGCCGACCCCGAAGCCAAGCGCAAGATCATCGGCCGCGAATTCGTCGAAGTCTTCCAGGACGAA
GCCGGCAAACTGCAGGGCGCCAAATGGCTGGCGCAAGGCACCATCTACCCCGACGTCATCGAATCGGCCGGCGCCAAGAC
CGGCAAGGCCACCTCGATCAAATCGCACCACAACGTCGGCGGCCTGCCCGATACGCTCAACCTGCAACTGCTCGAGCCGC
TGCGCGAACTGTTCAAGGACGAAGTGCGCGAACTGGGCGTGGCCCTGGGCCTGCCGCCGCAGATGGTCTACCGCCACCCG
TTCCCCGGCCCCGGCCTGGGCGTGCGCATCCTGGGCGAAGTCAAGCACGAGTACGCCGAACTGCTGCGCCGCGCCGACGC
CATCTTCATCGAGGAACTGCGCAACGCCAAGGACCCGGCCAGCGGCCTGACCTGGTACGAACTCACCTCGCAAGCCTTCG
CCGTGTTCCTGCCGGTCAAATCGGTCGGCGTCATGGGCGACGGCCGCACCTACGAATACGTCGTCGCGCTGCGCGCCGTG
CAGACCTTCGACTTCATGACCGCCGACTGGGCGCCCCTGCCGCACCCGCTGCTGGCACGCGTCTCCTCGCGCATCATCAA
CGAAGTGCGCGGCATCAACCGGGTGGTGTACGACGTATCGAGCAAGCCGCCTGCGACGATTGAGTGGGAGTGA

Protein sequence :
MHQRILILDYGSQVTQLIARRVREAGVYSEIHAGDVDDAFVRDQVAQGLKGIILSGSHASAYEEGSMRVPAAVFEVGVPV
LGICYGMQSMAQQLGGTVSFSDHREFGYAEVRAHGHTKLLDGLADFTTDEGHGMLKVWMSHGDKVTELPPGFKLMASTAS
CPIAGMADEDRGFYAVQFHPEVTHTVQGKAMLARFVKDICGCEGDWNMPDYISEAVARIREQVGSDEVILGLSGGVDSSV
AAALIHRAIGDQLTCVFVDHGLLRLDEGKQVMQTFAENMGVKIVHVDATSQFMGKLTGVADPEAKRKIIGREFVEVFQDE
AGKLQGAKWLAQGTIYPDVIESAGAKTGKATSIKSHHNVGGLPDTLNLQLLEPLRELFKDEVRELGVALGLPPQMVYRHP
FPGPGLGVRILGEVKHEYAELLRRADAIFIEELRNAKDPASGLTWYELTSQAFAVFLPVKSVGVMGDGRTYEYVVALRAV
QTFDFMTADWAPLPHPLLARVSSRIINEVRGINRVVYDVSSKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 2e-123 51
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 1e-123 51
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 1e-123 51
guaA NP_938969.1 GMP synthase Not tested Not named Protein 5e-107 48