Gene Information

Name : thyA (MYPU_5380)
Accession : NP_326369.1
Strain : Mycoplasma pulmonis UAB CTIP
Genome accession: NC_002771
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 662446 - 663306 bp
Length : 861 bp
Strand : -
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGAAACAATATTTAGACTTTTTAAAATGAGTATTAGAAAAGGGAAAACATAAGGAAAATAGAACTAGTGTTGACACAAT
TAGTGCCTTTGGTTATCAAATGCGTTTTGATCTATCTAAGGGCTTTCCTTTGGTTACAACAAAGAAAACTAATTTTAGTG
CTATAGCTCATGAATTACTGTGATTTATAAAAGGTGATACTAACATTAAATATCTAGTTGATAACAAAGTTAACATTTGA
AATCAATGACCTTATGAGAGTTATAAAAAAAGTCAAGATTTTCAAAGCGAGAGCTTAAAAGAGTTTATTCAAAAAATCAA
AGATGATAATGAATTTGCTCAAAAACATGGTAATTTAGGTCCAGTTTATGGAAAGCAATGAAGAGACTTTTTGGGAATAG
ATCAATTAAAAAAAGTTATTGAACAAATAAAAAATAATCCAAACTCTAGAAGACTAATAGTTTCTTCATGAAATCCAAGT
GAAATAGATACTATGCTTTTACCTCCTTGTCATACTTTGTTTCAATTTTATGTAAATGATAATAAGCTTTCATGTCATCT
ATATCAACGAAGTGCTGATGCTTTTTTGGGTATTCCTTTTAACATAGCCTCTTATGCACTTTTGACTTTTTTATTAGCTC
AAGAAACTAATTTAGAAGTTGGTGATTTTGTTCATTCAATTGGAGATGCTCACATTTATGTAAATCATCTTGAGCAAGTA
AAAACTCAACTAAAAAGAAATCCAAAAGAACTGCCAAAATTAATAATCAAAAACAAAAATATTTTTGAAATTAATTTTGA
AGATATTGAATTAGTTGACTATGAATTTGATCCAATTATTAAAGGGGAAGTGGCGGTTTAA

Protein sequence :
MKQYLDFLKWVLEKGKHKENRTSVDTISAFGYQMRFDLSKGFPLVTTKKTNFSAIAHELLWFIKGDTNIKYLVDNKVNIW
NQWPYESYKKSQDFQSESLKEFIQKIKDDNEFAQKHGNLGPVYGKQWRDFLGIDQLKKVIEQIKNNPNSRRLIVSSWNPS
EIDTMLLPPCHTLFQFYVNDNKLSCHLYQRSADAFLGIPFNIASYALLTFLLAQETNLEVGDFVHSIGDAHIYVNHLEQV
KTQLKRNPKELPKLIIKNKNIFEINFEDIELVDYEFDPIIKGEVAV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_189147.1 thymidylate synthase Not tested ¥ÕSP¥â Protein 4e-74 55
thyA YP_001800914.1 thymidylate synthase Not tested Not named Protein 2e-57 47