Gene Information

Name : thyA (SAV1427)
Accession : NP_371951.1
Strain : Staphylococcus aureus Mu50
Genome accession: NC_002758
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 1508996 - 1509952 bp
Length : 957 bp
Strand : -
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGTTGAATTCATTTGATGCAGCATATCACAGTCTTTGTGAAGAGGTTTTAGAAATAGGAAATACACGAAATGATCGCAC
AAATACAGGTACGATTTCGAAATTTGGTCATCAACTTCGCTTTGACTTATCTAAAGGATTTCCACTATTAACGACAAAGA
AAGTTTCTTTTAAATTAGTAGCAACCGAATTATTATGGTTCATTAAAGGAGATACAAACATCCAATACTTATTAAAATAT
AATAATAATATTTGGAACGAATGGGCTTTTGAAAATTATATAAAATCAGACGAGTATAACGGTCCAGATATGACAGATTT
CGGGCATCGTGCATTGAGTGATCCTGAATTTAACGAACAATATAAAGAACAAATGAAACAATTTAAGCAACGTATTCTTG
AAGATGATACTTTTGCGAAGCAATTCGGTGATTTAGGAAATGTTTATGGTAAACAATGGCGAGATTGGGTTGATAAAGAT
GGTAATCATTTTGATCAACTTAAAACAGTAATTGAACAAATTAAGCATAATCCAGATTCAAGACGACACATCGTATCTGC
ATGGAATCCAACAGAAATTGATACAATGGCACTTCCGCCTTGTCATACCATGTTCCAGTTTTATGTCCAAGATGGTAAGT
TAAGTTGCCAGTTATACCAACGTAGCGCAGATATCTTTTTAGGTGTGCCATTTAATATCGCAAGCTACGCTTTATTGACA
CACCTTATTGCCAAAGAATGTGGACTTGAAGTAGGAGAATTTGTGCATACATTTGGAGATGCACATATTTATTCAAATCA
TATTGATGCGATTCAAACACAATTAGCACGTGAAAGCTTCAATCCTCCAACATTAAAAATTAACAGTGACAAGTCTATTT
TCGACATAAATTATGAAGATTTGGAAATTGTTGACTATGAATCACATCCAGCAATAAAAGCTCCAATAGCAGTGTAG

Protein sequence :
MLNSFDAAYHSLCEEVLEIGNTRNDRTNTGTISKFGHQLRFDLSKGFPLLTTKKVSFKLVATELLWFIKGDTNIQYLLKY
NNNIWNEWAFENYIKSDEYNGPDMTDFGHRALSDPEFNEQYKEQMKQFKQRILEDDTFAKQFGDLGNVYGKQWRDWVDKD
GNHFDQLKTVIEQIKHNPDSRRHIVSAWNPTEIDTMALPPCHTMFQFYVQDGKLSCQLYQRSADIFLGVPFNIASYALLT
HLIAKECGLEVGEFVHTFGDAHIYSNHIDAIQTQLARESFNPPTLKINSDKSIFDINYEDLEIVDYESHPAIKAPIAV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_189147.1 thymidylate synthase Not tested ¥ÕSP¥â Protein 1e-131 86