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Name : clpB (MT0397) Accession : NP_334805.1 Strain : Mycobacterium tuberculosis CDC1551 Genome accession: NC_002755 Putative virulence/resistance : Virulence Product : ATP-dependent Clp protease, ATP-binding subunit ClpB Function : - COG functional category : O : Posttranslational modification, protein turnover, chaperones COG ID : COG0542 EC number : - Position : 459545 - 462091 bp Length : 2547 bp Strand : - Note : identified by similarity to GP:4098131; match to protein family HMM PF00004; match to protein family HMM PF02861 DNA sequence : GTGGACTCGTTTAACCCGACGACCAAGACGCAGGCGGCGCTAACCGCGGCGTTACAGGCGGCTTCGACCGCCGGCAATCC CGAGATCCGGCCCGCTCACCTGCTGATGGCGCTGCTGACCCAAAACGACGGTATCGCCGCACCGCTACTGGAGGCTGTCG GTGTCGAGCCCGCCACCGTCCGCGCCGAAACCCAGCGCCTGCTCGACCGTTTGCCGCAGGCGACTGGAGCCAGCACGCAG CCGCAGCTGTCCCGCGAGTCGTTAGCGGCGATCACCACCGCGCAGCAGCTGGCCACCGAGCTGGACGACGAGTACGTCTC CACCGAGCACGTGATGGTCGGGCTGGCCACCGGTGACTCCGACGTCGCCAAGCTGTTGACCGGCCACGGCGCCTCGCCGC AGGCGCTGCGGGAGGCGTTCGTCAAGGTGCGCGGCAGCGCCCGGGTCACCAGCCCCGAACCGGAGGCGACCTATCAGGCG CTGCAGAAGTACTCCACCGACCTGACCGCCCGCGCCCGCGAAGGCAAACTCGACCCGGTCATCGGCCGCGACAACGAGAT CCGCCGCGTGGTGCAGGTGCTGTCCCGTCGCACCAAGAACAACCCGGTGCTGATCGGTGAGCCCGGCGTCGGCAAGACCG CGATCGTGGAGGGCCTGGCGCAGCGCATCGTGGCCGGCGACGTGCCGGAGAGCTTGCGCGACAAGACCATCGTCGCGCTC GATCTCGGCTCGATGGTCGCCGGCTCCAAATACCGCGGCGAATTCGAGGAACGGCTCAAGGCCGTCCTCGACGACATCAA GAACTCGGCCGGCCAAATCATCACGTTCATCGACGAGCTGCACACCATCGTCGGCGCCGGCGCCACCGGCGAGGGGGCGA TGGACGCCGGCAACATGATCAAGCCGATGCTGGCCCGCGGCGAGTTACGGCTGGTCGGGGCGACCACGCTGGACGAATAC CGCAAGCACATCGAGAAGGACGCCGCGCTCGAGCGCCGTTTCCAACAGGTGTACGTCGGCGAGCCGTCGGTGGAGGACAC CATCGGCATCCTGCGCGGGCTCAAAGACCGCTACGAGGTGCACCACGGGGTGCGCATCACCGACTCGGCGCTGGTGGCAG CTGCCACTTTGAGCGACCGGTATATCACCGCCCGCTTCCTGCCCGACAAGGCCATCGACCTGGTCGACGAGGCGGCCAGC CGGCTGCGGATGGAGATCGACTCGCGGCCCGTCGAGATCGACGAGGTCGAGCGGCTGGTGCGCCGGCTGGAGATCGAAGA GATGGCGCTGTCCAAAGAAGAAGACGAGGCGTCGGCGGAGCGGTTGGCCAAGCTGCGCTCCGAGCTGGCCGACCAGAAAG AGAAGTTGGCCGAGCTCACCACCCGCTGGCAGAACGAGAAGAACGCGATCGAAATCGTCCGCGACCTCAAGGAGCAGCTG GAAGCCCTGCGCGGGGAATCCGAGCGGGCCGAACGCGACGGCGACCTGGCCAAGGCCGCCGAGCTGCGCTACGGACGCAT CCCCGAGGTGGAGAAGAAGCTCGACGCGGCGTTGCCGCAGGCGCAGGCCCGGGAGCAGGTGATGCTCAAGGAGGAGGTCG GTCCCGACGACATCGCCGACGTGGTGTCGGCGTGGACCGGCATCCCGGCCGGTCGGCTGCTGGAAGGCGAGACCGCCAAG CTGCTGCGCATGGAAGACGAGCTGGGCAAGCGGGTCATCGGGCAGAAGGCCGCGGTTACCGCAGTCTCTGATGCGGTGCG GCGCAGCCGGGCCGGGGTGTCCGACCCCAACCGGCCCACCGGGGCGTTCATGTTCCTCGGCCCGACCGGTGTCGGCAAGA CCGAGCTGGCCAAGGCGCTGGCCGACTTCCTGTTCGACGACGAGCGGGCGATGGTCCGCATCGACATGAGCGAGTACGGC GAGAAGCACACCGTGGCTCGGTTGATCGGCGCCCCGCCCGGCTATGTGGGATACGAGGCGGGCGGTCAGCTGACCGAGGC GGTGCGCCGGCGTCCKTACACGGTGGTGCTGTTCGACGAGATCGAGAAGGCGCACCCGGACGTGTTCGACGTGCTGCTGC AGGTCCTCGACGAGGGCCGGCTCACCGACGGGCACGGCCGCACGGTCGACTTCCGCAACACCATCTTGATCCTGACGTCC AACCTGGGGTCGGGTGGCAGCGCCGAGCAGGTGCTGGCCGCGGTGCGCGCTACGTTCAAGCCGGAGTTCATCAACCGGCT CGACGACGTGCTCATCTTTGAGGGTCTCAACCCCGAAGAGCTGGTGCGCATCGTCGACATCCAGCTGGCGCAGCTGGGCA AGCGGCTGGCGCAGCGGCGGCTGCAGCTGCAGGTCTCGCTGCCGGCCAAGCGCTGGTTGGCGCAGCGCGGATTCGACCCG GTGTACGGGGCGCGGCCGTTGCGCCGGCTGGTGCAGCAGGCCATCGGTGACCAGCTGGCCAAGATGCTGTTGGCCGGCCA GGTGCACGACGGCGATACCGTGCCGGTCAACGTCAGCCCCGACGCCGACTCGCTGATCCTGGGCTGA Protein sequence : MDSFNPTTKTQAALTAALQAASTAGNPEIRPAHLLMALLTQNDGIAAPLLEAVGVEPATVRAETQRLLDRLPQATGASTQ PQLSRESLAAITTAQQLATELDDEYVSTEHVMVGLATGDSDVAKLLTGHGASPQALREAFVKVRGSARVTSPEPEATYQA LQKYSTDLTARAREGKLDPVIGRDNEIRRVVQVLSRRTKNNPVLIGEPGVGKTAIVEGLAQRIVAGDVPESLRDKTIVAL DLGSMVAGSKYRGEFEERLKAVLDDIKNSAGQIITFIDELHTIVGAGATGEGAMDAGNMIKPMLARGELRLVGATTLDEY RKHIEKDAALERRFQQVYVGEPSVEDTIGILRGLKDRYEVHHGVRITDSALVAAATLSDRYITARFLPDKAIDLVDEAAS RLRMEIDSRPVEIDEVERLVRRLEIEEMALSKEEDEASAERLAKLRSELADQKEKLAELTTRWQNEKNAIEIVRDLKEQL EALRGESERAERDGDLAKAAELRYGRIPEVEKKLDAALPQAQAREQVMLKEEVGPDDIADVVSAWTGIPAGRLLEGETAK LLRMEDELGKRVIGQKAAVTAVSDAVRRSRAGVSDPNRPTGAFMFLGPTGVGKTELAKALADFLFDDERAMVRIDMSEYG EKHTVARLIGAPPGYVGYEAGGQLTEAVRRRPYTVVLFDEIEKAHPDVFDVLLQVLDEGRLTDGHGRTVDFRNTILILTS NLGSGGSAEQVLAAVRATFKPEFINRLDDVLIFEGLNPEELVRIVDIQLAQLGKRLAQRRLQLQVSLPAKRWLAQRGFDP VYGARPLRRLVQQAIGDQLAKMLLAGQVHDGDTVPVNVSPDADSLILG |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| STY0294 | NP_454876.1 | ClpB-like protein | Not tested | SPI-6 | Protein | 1e-104 | 43 |
| aec27 | YP_851418.1 | ATPase | Not tested | PAI II APEC-O1 | Protein | 2e-105 | 42 |
| aec27 | AAQ96721.1 | Aec27 | Not tested | AGI-1 | Protein | 2e-105 | 42 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| clpB | NP_334805.1 | ATP-dependent Clp protease, ATP-binding subunit ClpB | VFG2076 | Protein | 4e-112 | 44 |
| clpB | NP_334805.1 | ATP-dependent Clp protease, ATP-binding subunit ClpB | VFG2084 | Protein | 1e-111 | 41 |
