Gene Information

Name : nrdF2 (MT3133)
Accession : NP_337650.1
Strain : Mycobacterium tuberculosis CDC1551
Genome accession: NC_002755
Putative virulence/resistance : Unknown
Product : ribonucleotide-diphosphate reductase subunit beta
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0208
EC number : 1.17.4.1
Position : 3404141 - 3405115 bp
Length : 975 bp
Strand : -
Note : B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE

DNA sequence :
GTGACTGGAAACGCAAAGCTAATTGATCGAGTCTCAGCGATCAACTGGAACCGACTGCAAGATGAGAAGGACGCCGAGGT
CTGGGATCGGCTGACCGGAAACTTCTGGCTGCCCGAGAAGGTGCCGGTGTCCAATGACATCCCGTCGTGGGGCACCCTGA
CCGCCGGCGAGAAGCAACTAACCATGCGGGTCTTCACCGGCCTGACCATGCTGGACACCATCCAGGGCACCGTTGGTGCG
GTCAGCCTGATTCCCGACGCGCTGACTCCGCATGAGGAGGCGGTGTTGACCAACATCGCGTTTATGGAGTCGGTGCACGC
CAAGAGCTACAGCCAGATCTTCTCCACGCTGTGTTCCACCGCCGAGATCGACGACGCCTTCCGCTGGTCGGAGGAAAATC
GCAATCTGCAGCGCAAGGCCGAGATCGTGCTGCAGTACTACCGCGGCGACGAGCCGCTCAAGCGCAAGGTGGCCTCCACC
CTGCTGGAGAGCTTCCTGTTCTACTCTGGGTTCTACCTGCCGATGTACTGGTCGAGTCGGGCCAAGTTGACCAACACCGC
CGACATGATCCGGCTGATCATCCGCGACGAGGCCGTGCACGGTTACTACATCGGCTATAAGTTCCAGCGTGGTCTGGCGT
TGGTTGACGACGTCACGCGCGCCGAGCTCAAGGACTACACCTACGAGCTACTGTTCGAGCTCTACGACAACGAGGTGGAA
TACACCCAGGACCTCTACGACGAGGTCGGGCTAACCGAGGACGTCAAGAAGTTCTTGCGCTACAACGCCAACAAGGCGCT
GATGAACCTCGGCTATGAGGCGCTGTTCCCCCGCGATGAGACCGACGTGAACCCGGCCATCCTGTCGGCGCTGTCACCCA
ACGCCGACGAGAACCATGACTTCTTCTCCGGATCCGGGTCGAGCTATGTGATCGGCAAGGCGGTCGTCACCGAGGACGAT
GACTGGGACTTCTAG

Protein sequence :
MTGNAKLIDRVSAINWNRLQDEKDAEVWDRLTGNFWLPEKVPVSNDIPSWGTLTAGEKQLTMRVFTGLTMLDTIQGTVGA
VSLIPDALTPHEEAVLTNIAFMESVHAKSYSQIFSTLCSTAEIDDAFRWSEENRNLQRKAEIVLQYYRGDEPLKRKVAST
LLESFLFYSGFYLPMYWSSRAKLTNTADMIRLIIRDEAVHGYYIGYKFQRGLALVDDVTRAELKDYTYELLFELYDNEVE
YTQDLYDEVGLTEDVKKFLRYNANKALMNLGYEALFPRDETDVNPAILSALSPNADENHDFFSGSGSSYVIGKAVVTEDD
DWDF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
cur_1479 YP_001800873.1 ribonucleoside-diphosphate reductase subunit beta Not tested Not named Protein 5e-114 74