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Name : hsdM (MT2826) Accession : NP_337331.1 Strain : Mycobacterium tuberculosis CDC1551 Genome accession: NC_002755 Putative virulence/resistance : Unknown Product : type I restriction system adenine methylase Function : - COG functional category : V : Defense mechanisms COG ID : COG0286 EC number : - Position : 3063184 - 3064806 bp Length : 1623 bp Strand : - Note : identified by similarity to EGAD:149347; match to protein family HMM PF02384; match to protein family HMM PF02506 DNA sequence : ATGCCGCCCAGGAAGAAGCAGGCGCCGCAGGCGCCGTCGACGATGAAGGAGCTCAAAGACACGCTCTGGAAGGCCGCCGA CAAGCTGCGCGGGTCGCTGTCGGCCAGCCAATACAAGGACGTGATCCTCGGCCTGGTGTTCCTTAAGTACGTGTCCGACG CGTATGACGAACGGCGCGAGGCAATCCGTGCCGAGTTGGCGGCCGAAGGAATGGAGGAGTCTCAGATAGAAGACCTGATC GACGATCCCGAGCAGTACCAGGGTTACGGCGTATTCGTCGTGCCGGTGAGTGCGCGCTGGAAGTTCTTGGCAGAGAACAC AAAAGGCAAGCCAGCCGTTGGTGGTGAGCCGGCGAAGAACATCGGTCAGCTGATCGACGAGGCGATGGACGCGGTAATGA AGGCCAATCCAACACTCGGTGGGACGCTGCCGAGGCTGTATAACAAGGACAACATCGACCAGCGCCGGCTCGGTGAGCTG ATCGACCTATTTAACAGTGCGCGCTTCAGCCGGCAGGGCGAGCACCGCGCCCGGGATCTGATGGGTGAGGTCTACGAATA CTTCCTCGGCAATTTCGCTCGCGCGGAAGGGAAGCGGGGTGGCGAGTTCTTTACCCCGCCCAGCGTGGTCAAGGTGATCG TGGAGGTGCTGGAGCCGTCGAGTGGGCGGGTGTATGACCCGTGCTGCGGTTCCGGAGGCATGTTTGTGCAGACCGAGAAG TTCATCTACGAACACGACGGCGATCCGAAGGATGTCTCGATCTATGGCCAGGAAAGCATTGAGGAGACCTGGCGGATGGC GAAGATGAACCTCGCCATCCACGGCATCGACAACAAGGGGCTCGGCGCCCGATGGAGTGATACCTTCGCCCGCGACCAGC ACCCGGACGTGCAGATGGACTACGTGATGGCCAATCCGCCGTTCAACATCAAAGACTGGGCCCGCAACGAGGAAGACCCA CGCTGGCGCTTCGGTGTTCCGCCCGCCAATAACGCCAACTACGCATGGATTCAGCACATCCTGTACAAGTTGGCGCCGGG AGGTCGGGCGGGCGTGGTGATGGCCAACGGGTCGATGTCGTCGAACTCCAACGGCGAGGGGGATATTCGCGCGCAGATCG TGGAGGCGGATTTGGTTTCCTGCATGGTCGCGTTACCCACCCAGCTGTTCCGCAGCACCGGAATCCCGGTGTGCCTGTGG TTTTTCGCCAAAGACAAGGCGGCAGGTAAGCAAGGGTCTATCGACCGGTGCGGGCAGGTGCTGTTCATCGACGCTCGTGA ACTGGGCGACCTAGTGGACCGGGCCGAGCGGGCGCTGACCAACGAGGAGATCGTCCGCATCGGGGATACCTTCCACGCGT GGCGCGGGTCGAAGTCGGCTGCCGTCAAAGGGATTATGTACGAGGATGTTCCGGGGTTCTGTAAGTCGGCGACGTTGGCG GAGATCAAGGCGACCGACTATGCGCTCACGCCGGGGCGGTATGTGGGTACGCCCGCGGTCGAGGACGACGGAGAGCCGAT CGACGAGAAGATGGCCCGGTTGTCGAAGGCGTTGCTGGAGGCGTTCGATGAGTCGGCGCGGCTGGAAAGGGTCGTGCGGG AGCAACTGGGGCGGCTTAGATGA Protein sequence : MPPRKKQAPQAPSTMKELKDTLWKAADKLRGSLSASQYKDVILGLVFLKYVSDAYDERREAIRAELAAEGMEESQIEDLI DDPEQYQGYGVFVVPVSARWKFLAENTKGKPAVGGEPAKNIGQLIDEAMDAVMKANPTLGGTLPRLYNKDNIDQRRLGEL IDLFNSARFSRQGEHRARDLMGEVYEYFLGNFARAEGKRGGEFFTPPSVVKVIVEVLEPSSGRVYDPCCGSGGMFVQTEK FIYEHDGDPKDVSIYGQESIEETWRMAKMNLAIHGIDNKGLGARWSDTFARDQHPDVQMDYVMANPPFNIKDWARNEEDP RWRFGVPPANNANYAWIQHILYKLAPGGRAGVVMANGSMSSNSNGEGDIRAQIVEADLVSCMVALPTQLFRSTGIPVCLW FFAKDKAAGKQGSIDRCGQVLFIDARELGDLVDRAERALTNEEIVRIGDTFHAWRGSKSAAVKGIMYEDVPGFCKSATLA EIKATDYALTPGRYVGTPAVEDDGEPIDEKMARLSKALLEAFDESARLERVVREQLGRLR |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| hsdM | YP_251979.1 | type I restriction-modification system DNA methylase | Not tested | SCCmec | Protein | 6e-123 | 49 |
| hsdM | BAH57701.1 | type I restriction-modification system DNA methylase | Not tested | Type-VII SCCmec | Protein | 3e-123 | 49 |
| hsdM | BAD24842.1 | HsdM protein | Not tested | Type-V SCCmec | Protein | 3e-122 | 48 |
| api49 | CAF28523.1 | putative HsdM-like N-methyl transferase | Not tested | YAPI | Protein | 7e-108 | 45 |
