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Name : lysS (MT1678) Accession : NP_336133.1 Strain : Mycobacterium tuberculosis CDC1551 Genome accession: NC_002755 Putative virulence/resistance : Unknown Product : lysyl-tRNA synthetase Function : - COG functional category : J : Translation, ribosomal structure and biogenesis COG ID : COG1190 EC number : 6.1.1.6 Position : 1839424 - 1842981 bp Length : 3558 bp Strand : - Note : catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA DNA sequence : TTGAGAAGGTGTGAAACGATCTCGTGGCTAGCGGTGGGAGTGGGACTCCACTTAACTGTCCCTGGCCTTCGCCGGGATGG TCGCGGCGTCCAGTCTAACAGCCATGACACGTCATCTAAGACAACGGCCGACATCAGCCGGTGCCCTCAGCACACCGATG CGGGGCTACAAAGGGCTGCAACGCCGGGCATTTCCCGGCTTTTGGGAATATCCTCGCGGTCTGTGACACTCACCAAACCT CGCTCGGCCACCAGGGGAAACTCCCGGTATCACTGGGTTCCCGCGGCAGCCGGCTGGACCGTCGGCGTGATCGCGACCCT GTCACTACTGGCCAGTGTGTCGCCGTTGATTCGGTGGATCATCAAGGTTCCGCGCGAATTCATCAACGATTATCTGTTCA ACTTCCCCGACACCAACTTCGCGTGGTCCTTCGTGCTGGCATTGCTGGCCGCCGCGTTAACGGCACGCAAACGCATTGCC TGGTTGGTCTTGCTGGCAAATATGGTCCTGGCCGCCGTGGTCAACGCCGCCGAGATCGCAGCGGGCGGCAACACCGCCGC CGAGAGCTTCGGGGAGAATCTCGGATTCGCCGTGCATGTTGTGGCAATCGTCGTTCTGGTGCTGGGCTATCGGGAGTTCT GGGCCAAGGTCCGCAGGGGCGCGCTGTTTCGGGCGGCTGCGGTGTGGCTTGCCGGCGCGGTGGTCGGAATCGTGGCGTCT TGGGGTCTGGTCGAACTGTTTCCGGGATCACTAGCGCCGGACGAGCGGTTGGGTTACGCGGCCAACCGGGTGGTCGGATT CGCCCTCGCCGATCCCGATCTGTTCACCGGCAGACCGCACGTCTTCCTCAACGCGATCTTCGGGTTGTTCGGCGCGTTCG CGTTGATCGGGGCTGCGATCGTCTTGTTCCTATCTCAGCGCGCTGACAATGCGCTGACCGGAGAGGACGAATCCGCTATC CGCGGGTTATTGGATTTGTATGGGAAGGACGACTCACTGGGCTACTTCGCCACCCGTCGCGACAAGTCGGTGGTATTCGC ATCCAGCGGCCGCGCCTGTATCACCTACCGTGTCGAGGTCGGTGTCTGCCTAGCCAGCGGCGACCCGGTAGGCGACCACA GAGCATGGCCGCAGGCCGTCGACGCGTGGCTGCGGCTGTGCCAGACCTACGGCTGGGCACCCGGCGTGATGGGCGCCAGT TCACAAGGGGCTCAGACATATCGCGAAGCGGGCCTAACCGCGCTCGAGCTGGGCGATGAGGCCATCCTGCGGCCAGCCGA TTTCAAGTTGTCCGGCCCGGAGATGCGCGGGGTGCGCCAGGCCGTGACGCGGGCCCGGCGGGCGGGGTTGACGGTGCGCA TCCGGCGGCATCGCGACATTGCCGAAGACGAGATGGCGCAGACCATCACACGGGCGGATTCCTGGCGCGACACCGAGACC GAGCGCGGCTTCTCGATGGCGCTGGGCCGCCTCGGCGACCCCGCGGACTCCGACTGCCTGCTGGTGGAGGCGATTGATCC GCACAACCAGGTGCTGGCAATGCTGTCGCTGGTGCCGTGGGGAACCACCGGTGTCTCCCTGGATTTGATGCGTCGTTCTC CACAATCCCCGAACGGCACTATCGAACTTATGGTCAGCGAACTCGCCTTGCACGCTGAAAGCCTTGGTATCACTCGTATT TCGTTGAACTTCGCGGTGTTTCGCGCGGCCTTCGAGCAGGGCGCCCAACTCGGCGCCGGCCCGGTTGCCCGGTTGTGGCG GGGGCTGCTGGTCTTCTTCTCACGGTGGTGGCAGCTCGAGACGCTCTACCGCTCCAACATGAAGTACCAACCCGAATGGG TACCGCGCTACGCCTGCTACGAAGACGCCCGAGTGATTCCCCGAGTGGGCGTCGCCTCGGTGATCGCAGAGGGGTTCCTC GTGCTGCCGTTCAGCCGGCGCAACCGAGTACACACGGGGCATCATCCGGCAGTGCCCGAGCGGTTGGCGGCCACCGGCCT ATTGCATCACGACGGCTCGGCACCGGACGTGAGCGGGCTGCGGCAAGTAGGCCTCACCAATGGCGACGGGGTCGAGCGGC GGCTACCCGAGCAGGTGCGAGTTCGGTTCGACAAGCTAGAGAAGCTGCGGAGCAGCGGCATTGACGCCTTTCCCGTGGGC CGGCCGCCCAGTCACACGGTGGCACAGGCGCTGGCCGCAGACCACCAGGCTAGCGTGTCGGTGTCCGGACGCATCATGCG AATACGTAACTACGGTGGTGTGTTGTTCGCCCAGCTGCGCGACTGGTCGGGCGAAATGCAAGTGCTGCTGGATAATTCAC GCCTGGACCAGGGCTGCGCGGCCGACTTCAACGCGGCGACCGATCTGGGTGATCTGGTGGAGATGACCGGACACATGGGC GCCAGCAAGACCGGAACTCCATCGTTGATCGTCAGCGGCTGGCGCCTGATCGGTAAGTGTTTGCGACCGTTGCCGAATAA GTGGAAGGGGCTACTGGATCCCGAAGCCCGAGTCCGGACCCGTTACCTCGACCTGGCGGTCAACGCTGAGTCCCGTGCGC TGATCACCGCTCGCAGCAGCGTGCTGCGCGCTGTGCGCGAGACGCTGTTCGCAAAGGGATTCGTCGAGGTCGAAACGCCG ATCCTACAGCAGCTGCACGGCGGCGCCACCGCCCGACCGTTCGTCACGCACATCAACACGTATTCCATGGATCTGTTCCT GCGCATCGCACCAGAGCTCTACCTCAAGCGCCTGTGCGTCGGCGGCGTGGAACGGGTATTCGAGCTCGGCCGTGCCTTTC GCAACGAGGGCGTCGACTTCAGCCACAACCCGGAGTTCACCCTACTGGAGGCCTATCAAGCACACGCCGACTACCTTGAG TGGATTGACGGCTGCCGCGAACTCATCCAGAACGCCGCCCAGGCCGCCAACGGGGCGCCCATCGCCATGCGGCCCCGGAC GGACAAGGGTTCCGACGGCACCCGCCACCACCTCGAACCGGTCGACATCTCCGGGATATGGCCGGTGCGGACGGTGCATG ATGCGATCTCGGAAGCACTCGGTGAACGCATCGACGCCGATACCGGCTTGACCACTCTCCGCAAGCTGTGCGACGCCGCC GGTGTCCCCTATCGGACCCAATGGGATGCCGGCGCGGTCGTGCTCGAGCTATACGAGCACCTGGTGGAGTGCCGCACCGA GCAACCGACGTTCTACATCGACTTTCCGACATCGGTGTCACCGTTGACCCGACCGCATCGCAGCAAGCGCGGTGTCGCCG AGCGTTGGGACCTGGTGGCGTGGGGTATCGAGCTGGGCACCGCCTACAGCGAGCTGACCGACCCGGTGGAGCAACGGCGC CGCCTGCAGGAGCAGTCCCTGCTGGCCGCCGGCGGAGACCCCGAGGCGATGGAACTCGACGAAGACTTCCTGCAAGCGAT GGAGTACGCCATGCCGCCCACCGGCGGCTTGGGCATGGGCATTGACCGGGTGGTCATGCTGATCACTGGGCGCAGCATTC GCGAAACACTGCCCTTTCCGTTGGCAAAACCGCATTAG Protein sequence : MRRCETISWLAVGVGLHLTVPGLRRDGRGVQSNSHDTSSKTTADISRCPQHTDAGLQRAATPGISRLLGISSRSVTLTKP RSATRGNSRYHWVPAAAGWTVGVIATLSLLASVSPLIRWIIKVPREFINDYLFNFPDTNFAWSFVLALLAAALTARKRIA WLVLLANMVLAAVVNAAEIAAGGNTAAESFGENLGFAVHVVAIVVLVLGYREFWAKVRRGALFRAAAVWLAGAVVGIVAS WGLVELFPGSLAPDERLGYAANRVVGFALADPDLFTGRPHVFLNAIFGLFGAFALIGAAIVLFLSQRADNALTGEDESAI RGLLDLYGKDDSLGYFATRRDKSVVFASSGRACITYRVEVGVCLASGDPVGDHRAWPQAVDAWLRLCQTYGWAPGVMGAS SQGAQTYREAGLTALELGDEAILRPADFKLSGPEMRGVRQAVTRARRAGLTVRIRRHRDIAEDEMAQTITRADSWRDTET ERGFSMALGRLGDPADSDCLLVEAIDPHNQVLAMLSLVPWGTTGVSLDLMRRSPQSPNGTIELMVSELALHAESLGITRI SLNFAVFRAAFEQGAQLGAGPVARLWRGLLVFFSRWWQLETLYRSNMKYQPEWVPRYACYEDARVIPRVGVASVIAEGFL VLPFSRRNRVHTGHHPAVPERLAATGLLHHDGSAPDVSGLRQVGLTNGDGVERRLPEQVRVRFDKLEKLRSSGIDAFPVG RPPSHTVAQALAADHQASVSVSGRIMRIRNYGGVLFAQLRDWSGEMQVLLDNSRLDQGCAADFNAATDLGDLVEMTGHMG ASKTGTPSLIVSGWRLIGKCLRPLPNKWKGLLDPEARVRTRYLDLAVNAESRALITARSSVLRAVRETLFAKGFVEVETP ILQQLHGGATARPFVTHINTYSMDLFLRIAPELYLKRLCVGGVERVFELGRAFRNEGVDFSHNPEFTLLEAYQAHADYLE WIDGCRELIQNAAQAANGAPIAMRPRTDKGSDGTRHHLEPVDISGIWPVRTVHDAISEALGERIDADTGLTTLRKLCDAA GVPYRTQWDAGAVVLELYEHLVECRTEQPTFYIDFPTSVSPLTRPHRSKRGVAERWDLVAWGIELGTAYSELTDPVEQRR RLQEQSLLAAGGDPEAMELDEDFLQAMEYAMPPTGGLGMGIDRVVMLITGRSIRETLPFPLAKPH |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| lysS1 | YP_005682181.1 | lysyl-tRNA synthetase | Not tested | PiCp 7 | Protein | 3e-155 | 43 |
| lysS1 | YP_005684273.1 | lysyl-tRNA synthetase | Not tested | PiCp 7 | Protein | 1e-155 | 43 |
| lysX | YP_003784331.1 | lysyl-tRNA synthetase | Not tested | PiCp 7 | Protein | 1e-155 | 43 |
| lysS1 | YP_005686365.1 | lysyl-tRNA synthetase | Not tested | PiCp 7 | Protein | 1e-155 | 43 |
