Gene Information

Name : nrdF (SPy_0425)
Accession : NP_268726.1
Strain : Streptococcus pyogenes SF370
Genome accession: NC_002737
Putative virulence/resistance : Unknown
Product : ribonucleotide-diphosphate reductase subunit beta
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0208
EC number : 1.17.4.1
Position : 353276 - 354289 bp
Length : 1014 bp
Strand : +
Note : B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE

DNA sequence :
ATGACCCAACATTATTATGAACGTTCGCAATCCCCAATTGAATACGCCCTATCTGAAACACAAAAACAGTTGCGCTCCAT
CAATTGGAATTACCTTAATGATGACAAAGATTTAGAAGTGTGGAACCGTGTCACTCAAAATTTTTGGTTGCCTGAAAAGG
TTCCTGTTTCTAATGATTTAAATTCTTGGCGCTCCTTGGGTGAGGATTGGCAACAGCTCATCACAAGGACCTACACTGGG
TTGACCTTACTAGATACAGTACAAGCAACGGTTGGTGATGTGGCACAAATTCAGCATTCACAAACCGACCACGAACAAGT
CATCTATACGAACTTTGCCTTTATGGTGGGGATTCATGCCCGCTCTTACGGGACGATTTTTTCGACCCTTTGCAGCAGCG
AGCAAATCGAAGAAGCACATGAATGGGTGGTCTCAACACAGAGCTTGCAAGACCGTGCCCGTGTCTTGATTCCTTACTAT
ACGGGTGATGACCCTTTGAAATCAAAAGTAGCAGCAGCTATGATGCCAGGATTTTTGCTGTATGGCGGCTTTTACCTTCC
TTTTTACCTATCAGCACGTGGTAAAATGCCAAACACATCTGATATCATCCGCCTGATTTTACGCGACAAAGTTATTCACA
ACTATTACAGCGGTTACAAATACCAACAAAAAGTAGCACGTCTTAGCCCAGAAAAACAGGCTGAAATGAAGGCCTTTGTC
TTTGACTTGCTCTATGAACTCATCGACCTTGAAAAAGCTTACTTGAGAGAACTGTATGCAGGCTTTGATTTGGCAGAAGA
TGCTATCCGTTTTAGCCTTTATAACGCTGGAAAATTCCTTCAAAATTTAGGCTATGAGTCGCCCTTCACAGATGAAGAAA
CGCGCGTTTCACCAGAAGTATTTGCTCAGCTATCAGCGCGTGCAGACGAAAACCATGACTTTTTCTCAGGCAATGGCTCA
TCTTATGTGATGGGGATCACCGAAGAAACCACAGATGACGATTGGGAGTTTTAA

Protein sequence :
MTQHYYERSQSPIEYALSETQKQLRSINWNYLNDDKDLEVWNRVTQNFWLPEKVPVSNDLNSWRSLGEDWQQLITRTYTG
LTLLDTVQATVGDVAQIQHSQTDHEQVIYTNFAFMVGIHARSYGTIFSTLCSSEQIEEAHEWVVSTQSLQDRARVLIPYY
TGDDPLKSKVAAAMMPGFLLYGGFYLPFYLSARGKMPNTSDIIRLILRDKVIHNYYSGYKYQQKVARLSPEKQAEMKAFV
FDLLYELIDLEKAYLRELYAGFDLAEDAIRFSLYNAGKFLQNLGYESPFTDEETRVSPEVFAQLSARADENHDFFSGNGS
SYVMGITEETTDDDWEF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
cur_1479 YP_001800873.1 ribonucleoside-diphosphate reductase subunit beta Not tested Not named Protein 1e-71 52