Gene Information

Name : hasB (SPy_2201)
Accession : NP_270108.1
Strain : Streptococcus pyogenes SF370
Genome accession: NC_002737
Putative virulence/resistance : Virulence
Product : UDP-glucose 6-dehydrogenase
Function : -
COG functional category : M : Cell wall/membrane/envelope biogenesis
COG ID : COG1004
EC number : 1.1.1.22
Position : 1833920 - 1835128 bp
Length : 1209 bp
Strand : +
Note : Best Blastp hit = sp|Q07172|UDG_STRPY UDP-GLUCOSE 6-DEHYDROGENASE (UDP-GLC DEHYDROGENASE) (UDP-GLCDH) (UDPGDH) >gi|1075776|pir||A46089 UDPglucose 6-dehydrogenase (EC 1.1.1.22) - Streptococcus pyogenes >gi|8569328|pdb|1DLI|A Chain A, The First Structure Of

DNA sequence : 
ATGAAAATAGCAGTTGCTGGATCAGGATATGTTGGATTATCACTAGGAGTTCTTTTATCACTTCAAAACGAAGTCACTAT
TGTTGATATTCTTCCCTCTAAAGTTGATAAGATTAATAATGGCTTATCACCAATTCAAGATGAATATATTGAATATTACT
TAAAAAGTAAGCAATTATCTATTAAAGCAACTTTAGATAGCAAAGCAGCTTATAAAGAAGCGGAACTGGTCATTATTGCC
ACACCTACAAATTACAACAGTAGAATTAATTATTTTGATACACAGCATGTTGAAACAGTTATCAAAGAGGTACTAAGCGT
TAATAGCCATGCAACTCTTATCATCAAATCAACAATTCCAATAGGTTTCATTACTGAAATGAGACAGAAATTCCAAACTG
ATCGTATTATCTTCAGCCCTGAATTTTTAAGAGAATCTAAAGCTTTATATGACAACTTATATCCAAGCCGAATTATTGTT
TCTTGTGAAGAAAACGATTCTCCAAAAGTAAAGGCAGACGCAGAAAAATTTGCACTTTTATTAAAGTCTGCAGCTAAAAA
AAATAATGTACCAGTACTTATTATGGGAGCTTCAGAAGCTGAAGCAGTAAAACTATTTGCCAATACTTATTTAGCGTTAA
GGGTAGCTTATTTTAATGAGTTAGACACTTACGCAGAATCGAGAAAATTAAATAGTCACATGATTATTCAAGGAATTTCT
TATGATGATCGAATAGGAATGCATTATAATAACCCATCATTTGGTTATGGAGGTTATTGTCTACCTAAAGATACGAAGCA
ATTATTGGCAAATTACAATAATATTCCTCAAACGCTAATTGAAGCTATCGTTTCATCAAATAATGTGCGCAAGTCCTATA
TTGCTAAGCAAATTATCAACGTCTTAGAAGAGCGGGAGTCCCCAGTAAAAGTAGTCGGGGTTTACCGTTTAATTATGAAA
AGTAACTCAGATAATTTTAGAGAAAGTGCTATCAAAGATGTTATTGACATTCTTAAAAGTAAAGACATTAAGATAATTAT
TTATGAGCCAATGTTAAACAAACTTGAATCTGAAGATCAATCTGTACTTGTAAATGATTTAGAGAATTTCAAGAAACAAG
CAAATATTATCGTAACTAATCGCTATGATAATGAATTACAAGATGTTAAAAATAAAGTTTACAGTAGAGATATTTTTAAT
AGAGACTAG

Protein sequence : 
MKIAVAGSGYVGLSLGVLLSLQNEVTIVDILPSKVDKINNGLSPIQDEYIEYYLKSKQLSIKATLDSKAAYKEAELVIIA
TPTNYNSRINYFDTQHVETVIKEVLSVNSHATLIIKSTIPIGFITEMRQKFQTDRIIFSPEFLRESKALYDNLYPSRIIV
SCEENDSPKVKADAEKFALLLKSAAKKNNVPVLIMGASEAEAVKLFANTYLALRVAYFNELDTYAESRKLNSHMIIQGIS
YDDRIGMHYNNPSFGYGGYCLPKDTKQLLANYNNIPQTLIEAIVSSNNVRKSYIAKQIINVLEERESPVKVVGVYRLIMK
SNSDNFRESAIKDVIDILKSKDIKIIIYEPMLNKLESEDQSVLVNDLENFKKQANIIVTNRYDNELQDVKNKVYSRDIFN
RD

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SSP0068 YP_300158.1 UDP-glucose 6-dehydrogenase Not tested SCC15305cap Protein 2e-70 51

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
hasB NP_270108.1 UDP-glucose 6-dehydrogenase VFG0963 Protein 7e-159 100