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Name : leuS (SPy_0173) Accession : NP_268552.1 Strain : Streptococcus pyogenes SF370 Genome accession: NC_002737 Putative virulence/resistance : Unknown Product : leucyl-tRNA synthetase Function : - COG functional category : J : Translation, ribosomal structure and biogenesis COG ID : COG0495 EC number : 6.1.1.4 Position : 157127 - 159628 bp Length : 2502 bp Strand : + Note : leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl DNA sequence : ATGACATTTTACGATCACACCGCTATTGAACCCAAATGGCAAGCCTTTTGGGCAGATAATCATACTTTTAAAACAGGAAC AGACGCATCAAAACCTAAGTTTTATGCCCTAGATATGTTCCCATACCCATCTGGAGCTGGTCTCCACGTTGGTCACCCAG AAGGCTATACAGCAACTGATATTCTCAGCCGTTTCAAACGTGCCCAAGGTCACAATATTCTCCACCCAATGGGTTGGGAT GCCTTTGGACTTCCTGCTGAGCAGTACGCTATGGATACTGGTAATGACCCAGCCGAGTTTACAGCTGAAAACATCGCTAA CTTCAAACGCCAGATTAATGCTCTTGGTTTCTCATACGACTGGGATCGTGAAGTTAACACAACTGACCCTAACTACTACA AGTGGACACAGTGGATCTTTACCAAGCTTTATGAAAAAGGCCTAGCCTACGAAGCTGAAGTTCCCGTTAACTGGGTTGAA GAATTGGGAACAGCTATCGCTAACGAAGAGGTTCTCCCTGATGGGACATCAGAACGTGGCGGCTACCCAGTTGTCAGAAA ACCCATGCGCCAATGGATGCTCAAAATCACTGCCTATGCAGAGCGCTTGCTAGAAGACTTGGAAGAAGTTGACTGGCCAG AATCAATCAAGGACATGCAACGCAACTGGATTGGTAAATCAACTGGTGCTAATGTAACCTTCAAGGTTAAGGATACAGAT AAGGACTTCACTGTCTTTACAACACGTCCTGACACGCTTTTTGGTGCAACTTACGCCGTTCTTGCTCCTGAGCATGCCTT GGTTGATGCTATTACAACAGCTGACCAAGCAGAAGCCGTTGCCAAATACAAACGTCAAGCAAGTCTCAAATCAGACCTTG CTCGTACAGATCTTGCCAAAGAAAAAACTGGTGTGTGGACAGGTGCCTATGCGATTAACCCAGTTAATGGTAACGAAATG CCAGTTTGGATTGCGGACTATGTCCTTGCCAGCTACGGTACTGGTGCTATCATGGCTGTTCCAGCCCACGATGAACGTGA CTGGGAATTCGCAAAACAATTTAAGCTAGACATCATCCCTGTTCTTGAAGGTGGTAATGTTGAAGAGGCTGCCTTTACAG AAGACGGTCTTCACATCAACTCAGGCTTCCTAGATGGTCTTGACAAAGCGTCAGCTATTGCCAAAATGGTCGAATGGCTT GAAGCAGAAGGCGTCGGTAATGAGAAAGTCACTTACCGTCTTCGTGACTGGCTCTTTAGCCGTCAACGTTATTGGGGTGA GCCAATCCCAATCATCCACTGGGAAGATGGGACCTCAACAGCGGTTCCTGAGAGTGAGTTGCCACTGGTTCTTCCAGTAA CGAAGGATATCCGTCCTTCAGGTACTGGTGAGAGCCCACTTGCTAACGTGACAGACTGGTTGGAAGTGACTCGTGAAGAT GGTGTGAAAGGTCGTCGTGAGACTAACACCATGCCACAATGGGCAGGTTCAAGCTGGTATTATCTTCGTTACATCGATCC ACACAACACTGAAAAACTGGCTGACGAGGAACTCCTCAAACAATGGTTGCCAGTTGATATCTATGTCGGTGGTGCAGAGC ATGCCGTGCTTCACCTTCTCTACGCTCGCTTCTGGCACAAGGTTCTTTACGATCTCGGTGTTGTACCTACCAAAGAGCCA TTCCAAAAACTCTTTAACCAAGGGATGATTTTGGGGACAAGCTACCGCGATAGCCGTGGTGCTCTTGTGGCAACTGACAA GGTTGAAAAACGTGATGGTAGCTTCTTCCATGTGGAAACTGGGGAAGAGCTTGAACAAGCACCAGCTAAGATGTCTAAAT CACTTAAGAACGTTGTCAACCCAGATGATGTTGTTGAGCAGTACGGTGCTGACACTCTTCGTGTTTACGAGATGTTCATG GGACCACTTGACGCTTCCATCGCCTGGTCTGAAGAAGGTCTTGAAGGCTCACGTAAGTTCTTGGACCGTGTTTACCGTTT GATCACAACTAAAGAGATCACTGAGGAAAATAGCGGAGCCCTTGACAAGGTTTACAACGAAACCGTTAAGGCCGTTACTG AGCAAGTTGACCAAATGAAATTCAACACAGCTATCGCTCAACTCATGGTATTTGTCAATGCAGCCAACAAGGAAGACAAA CTCTTTAGCGACTATGCCAAAGGCTTTGTTCAATTGATTGCACCATTTGCACCGCACTTAGGTGAGGAACTCTGGCAAGC CTTGACAGCCTCAGGTGAGTCAATCTCTTACGTGCCATGGCCAAGTTATGATGAAAGCAAATTGGTTGAAAACGATGTGG AAATCGTTGTCCAAATCAAAGGTAAGGTCAAAGCTAAACTTGTAGTTGCTAAAGACCTTTCACGCGAAGAATTACAAGAA GTTGCTCTTGCTAACGAAAAAGTCCAAGCCGAAATCGCAGGCAAAGACATCATCAAAGTCATCGCAGTACCAAACAAACT CGTTAATATTGTTATCAAATAG Protein sequence : MTFYDHTAIEPKWQAFWADNHTFKTGTDASKPKFYALDMFPYPSGAGLHVGHPEGYTATDILSRFKRAQGHNILHPMGWD AFGLPAEQYAMDTGNDPAEFTAENIANFKRQINALGFSYDWDREVNTTDPNYYKWTQWIFTKLYEKGLAYEAEVPVNWVE ELGTAIANEEVLPDGTSERGGYPVVRKPMRQWMLKITAYAERLLEDLEEVDWPESIKDMQRNWIGKSTGANVTFKVKDTD KDFTVFTTRPDTLFGATYAVLAPEHALVDAITTADQAEAVAKYKRQASLKSDLARTDLAKEKTGVWTGAYAINPVNGNEM PVWIADYVLASYGTGAIMAVPAHDERDWEFAKQFKLDIIPVLEGGNVEEAAFTEDGLHINSGFLDGLDKASAIAKMVEWL EAEGVGNEKVTYRLRDWLFSRQRYWGEPIPIIHWEDGTSTAVPESELPLVLPVTKDIRPSGTGESPLANVTDWLEVTRED GVKGRRETNTMPQWAGSSWYYLRYIDPHNTEKLADEELLKQWLPVDIYVGGAEHAVLHLLYARFWHKVLYDLGVVPTKEP FQKLFNQGMILGTSYRDSRGALVATDKVEKRDGSFFHVETGEELEQAPAKMSKSLKNVVNPDDVVEQYGADTLRVYEMFM GPLDASIAWSEEGLEGSRKFLDRVYRLITTKEITEENSGALDKVYNETVKAVTEQVDQMKFNTAIAQLMVFVNAANKEDK LFSDYAKGFVQLIAPFAPHLGEELWQALTASGESISYVPWPSYDESKLVENDVEIVVQIKGKVKAKLVVAKDLSREELQE VALANEKVQAEIAGKDIIKVIAVPNKLVNIVIK |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| leuS | YP_281511.2 | leucyl-tRNA synthetase | Not tested | Not named | Protein | 0.0 | 99 |
