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Name : hsdM (SPy_1906) Accession : NP_269893.1 Strain : Streptococcus pyogenes SF370 Genome accession: NC_002737 Putative virulence/resistance : Unknown Product : type I site-specific deoxyribonuclease Function : - COG functional category : V : Defense mechanisms COG ID : COG0286 EC number : 3.1.21.3 Position : 1589139 - 1590719 bp Length : 1581 bp Strand : + Note : Best Blastp hit = gi|10956197 type IC modification subunit [Streptococcus thermophilus] >gi|11279435|pir||T44803 type I site-specific deoxyribonuclease (EC 3.1.21.3) chain hsdM [imported] - Streptococcus thermophilus plasmid pER35 >gi|6137148|gb|AAF04357. DNA sequence : ATGGCAGAGAAAACAACTTCACTCCGTCAAGCACTATGGCATTCGGCCGACCAATTACGTGGCCAAATGGATGCCAATGA CTATAAAAACTATCTTCTTGGACTTATTTTTTACAAACACTTATCTGATAAATTACTCTTGGCTGTTTGTGATAATCTAG AAAAACACTTCAATACCTTTACAGAGGCTCAAAAAATCTTTGAAGATGCTTATCAAGATGAAGGCCTAAAAGATGACCTC ATTTCTGTTGTTACTGGTGATTTAGGTTACTTTATCGAACCGACACTGACCTTTGAAAAACTCATCCAAGATGTTTATCA CAATACTTTCCAATTAGAATCATTAGCTCAAGGTTTTCGCGATATTGAACAAAGTGGTGAAGACTTTGAAAACTTATTTG AAGATATTGACCTCTACTCTAAAAAATTAGGCTCTACTCCTCAAAAACAAAATCAAACCATTTCTAATGTCATGAAAACA TTAAATGAAATTGACTTTGAGGCAGTAGATGGGGATACTTTAGGTGATGCTTATGAGTACTTGATTGGTGAATTTGCCAG TGAATCAGGAAAAAAAGCAGGTGAGTTCTATACCCCACAAGCTGTCTCTCACTTAATGACTCAGATTGTCTTTTTAGGTC GTGAAGATCAAAAAGGAATGACCCTCTATGACCCTGCTATGGGATCTGGATCACTCCTTTTAAATGCTAAGAAATATAGT AACCAATCCGATACCGTTTCTTACTATGGTCAAGAAATCAATACTTCTACTTATAACTTGGCTCGTATGAACATGATGCT TCATGGCGTTGCCATCGAGAACCAACACTTAAGTAACGCTGATACCTTGGATGCAGACTGGCCAACAGATGAACCAATCA ACTTTGATGGGGTGTTGATGAACCCACCTTATTCTTTGAAATGGTCAGCGACTGCTGGTTTCTTAACGGATCCACGGTTT TCAAGTTATGGTGTATTAGCACCAAAATCAAAAGCCGATTTTGCCTTTTTACTTCATGGTTTCTATCATTTAAAAAATAC AGGAACTATGGCGATTGTCTTACCACACGGTGTCCTTTTCCGTGGAGCTGCAGAAGGCAAGATTCGCCAAAAACTACTCG AACAAGGGGCTATCGATACCATTATCGGACTCCCATCAAATATCTTTTATAATACAAGCATCCCTACGACTATTATCATA TTAAAGAAGAACAGAACCAACAAAGATGTCTTCTTTATCGATGCTTCAAAAGAGTTTGATAAGGGTAAAAATCAAAACAC AATGACAGATAACCATATCAAAAAGATCCTTGATGCTTATAAGAGTCGTGATAATTCTGATAAGTTTTCATATTTAGCCT CATTTGATGAAATCATTGAAAATGACTATAACTTAAATATCCCACGCTATGTTGATACCTTTGAGGAAGTCCCAGTTAAA CCACTGCCAGAATTAGCTAAACAGCTCAGTGACATTGATCAAGAAATTGCCAAAACAAATGCCAAACTAGATCAACTCAT GAAACAACTAGTCGGAACAACCAAAGAAGCACAAGACGAATTGGATACTTTTAGAAACTAA Protein sequence : MAEKTTSLRQALWHSADQLRGQMDANDYKNYLLGLIFYKHLSDKLLLAVCDNLEKHFNTFTEAQKIFEDAYQDEGLKDDL ISVVTGDLGYFIEPTLTFEKLIQDVYHNTFQLESLAQGFRDIEQSGEDFENLFEDIDLYSKKLGSTPQKQNQTISNVMKT LNEIDFEAVDGDTLGDAYEYLIGEFASESGKKAGEFYTPQAVSHLMTQIVFLGREDQKGMTLYDPAMGSGSLLLNAKKYS NQSDTVSYYGQEINTSTYNLARMNMMLHGVAIENQHLSNADTLDADWPTDEPINFDGVLMNPPYSLKWSATAGFLTDPRF SSYGVLAPKSKADFAFLLHGFYHLKNTGTMAIVLPHGVLFRGAAEGKIRQKLLEQGAIDTIIGLPSNIFYNTSIPTTIII LKKNRTNKDVFFIDASKEFDKGKNQNTMTDNHIKKILDAYKSRDNSDKFSYLASFDEIIENDYNLNIPRYVDTFEEVPVK PLPELAKQLSDIDQEIAKTNAKLDQLMKQLVGTTKEAQDELDTFRN |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| SSP0053 | YP_300143.1 | type I restriction-modification system methyltransferase subunit | Not tested | SCC15305cap | Protein | 3e-113 | 49 |
| hsdM | NP_645209.1 | type I site-specific deoxyribonuclease LldI chain hsdM | Not tested | vSa¥á | Protein | 7e-110 | 47 |
| SAMSHR1132_16570 | YP_005326167.1 | restriction-modification system, M subunit | Not tested | vSa¥â | Protein | 1e-109 | 47 |
| SAMSHR1132_03780 | YP_005324900.1 | putative type I restriction enzyme modification protein | Not tested | vSa¥á | Protein | 7e-110 | 47 |
| SAS0394 | YP_042520.1 | restriction enzyme modification protein | Not tested | vSa¥á | Protein | 9e-110 | 47 |
| hsdM2 | YP_186690.1 | type I restriction-modification system, M subunit | Not tested | vSa¥â | Protein | 4e-110 | 47 |
| SAR0433 | YP_039884.1 | type I restriction enzyme modification protein | Not tested | vSa¥á | Protein | 8e-110 | 47 |
| ORF6 | BAC22943.1 | - | Not tested | etd PI | Protein | 7e-110 | 47 |
| hsdM1 | YP_185366.1 | type I restriction-modification system, M subunit | Not tested | vSa¥á | Protein | 4e-110 | 47 |
| SAS1732 | YP_043848.1 | type I restriction enzyme modification protein | Not tested | vSa¥â | Protein | 8e-110 | 47 |
| hsdM | YP_001331432.1 | type I restriction-modification system, methyltransferase subunit | Not tested | vSa¥á | Protein | 4e-110 | 47 |
| hsdM | NP_646568.1 | hypothetical protein | Not tested | vSa¥â | Protein | 8e-110 | 47 |
| hsdM | YP_493119.1 | type I restriction-modification system, M subunit | Not tested | vSa¥á | Protein | 4e-110 | 47 |
| SAV1808 | NP_372332.1 | type I restriction enzyme EcoR124II M protein | Not tested | vSa¥â | Protein | 8e-110 | 47 |
| SAKOR_00415 | YP_008490599.1 | Type I restriction-modification system methylation subunit | Not tested | vSa¥á | Protein | 4e-110 | 47 |
| SA1626 | NP_374915.1 | hypothetical protein | Not tested | vSa¥â | Protein | 8e-110 | 47 |
| SAR1899 | YP_041281.1 | type I restriction modification system modification protein | Not tested | vSa¥â | Protein | 5e-109 | 47 |
| hsdM | NP_373642.1 | type I site-specific deoxyribonuclease LldI subunit HsdM | Not tested | vSa¥á | Protein | 7e-110 | 47 |
| hsdM | NP_370955.1 | type I site-specific deoxyribonuclease LldI chain | Not tested | vSa¥á | Protein | 3e-109 | 47 |
| hsdM | YP_001332734.1 | type I restriction-modification system, methyltransferase subunit | Not tested | vSa¥â | Protein | 2e-110 | 47 |
| hsdM | YP_494443.1 | type I restriction-modification system, M subunit | Not tested | vSa¥â | Protein | 2e-110 | 47 |
| SAKOR_01757 | YP_008491945.1 | Type I restriction-modification system methylation subunit | Not tested | vSa¥â | Protein | 3e-110 | 47 |
