Gene Information

Name : guaA (CC_1620)
Accession : NP_420431.1
Strain : Caulobacter crescentus CB15
Genome accession: NC_002696
Putative virulence/resistance : Unknown
Product : bifunctional GMP synthase/glutamine amidotransferase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 1793148 - 1794710 bp
Length : 1563 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGACTCAGAAAACCGACCACCAGCGCGTCCTGATCGTCGACTTCGGCAGCCAGGTCACCCAACTGATCGCCCGCCGAGT
GCGCGAGGCGGGGGTCTATTGCGAGATCCATCCGTTCGACAAGGCCGAGGCCATTGTCGACGAGTACGCGCCCTCGGCGA
TCATCCTGTCGGGCGGTCCGGCCAGTGTGCTGGAGGCGGACAGCCCGCGCATCGGTCGCAAGCTGTTCGATCTGGGCCTG
CCGCTGCTGGCCATCTGCTACGGCCAGCAACTGCTGTGCGACGTCTTGAGCGGCAAGGTCGAGGGTGGTCACGCGGGCGA
ATTCGGCCGCGCCGAGCTGACCATCGGCAAGGATAGCCCGATGTTCCAAGGCCTGGCCGGTGTCGGCGGCGTCGAGACGG
TGTGGATGAGCCACGGCGATCGCGTCACGGCGATCCCGGAAGGCTTCGAGGTGATCGGTACGTCGACCGGCGCGCCGTTC
GCGGCGATCGCCAATGACGCCAAGAAGATCTACGCCCTGCAGTTCCATCCTGAGGTCTATCACACGGTCAACGGACCGGC
GATGTACCGCAATTTCCTGTTCAATATCGCGGGGCTGAAGGGCGACTGGACGATGGCGGCGTTCCGCCAGGAGATGGTCC
AGAAGATCCGCGACCAGGTCGGAGACGGCAAGGTGATCTGCGGCCTGTCGGGCGGCGTCGACAGCTCGGTGGCCGCCGTG
CTGATCCACGAGGCGATCGGCGACCAGCTGACCTGCGTGTTCGTCGACACGGGCCTCTTGCGCAAGAACGAGGCCGACCA
GGTCGTGACCCTGTTCCGCGACCACTACAACATCCCGCTGGTCCACGTGGACGCCGGCGACCTGTTCCTGGGCGAGCTGG
CCGGCGTCAGCGATCCCGAAACCAAGCGCAAGACCATCGGCCGCCTGTTCATCGACGTGTTCGACAAGGAAGCCGCCAAG
ATCGAGGGCGCGACGTTCCTGGCCCAGGGCACGCTCTATCCGGACGTCGTCGAGAGCGTCTCGGCCCGCGGCGGCCCCTC
GGCGGTGATCAAGAGCCACCACAACGTCGGCGGCTTGCCCGACTACATGAAGCTGAAGCTGGTCGAGCCGCTGCGCGAGC
TGTTCAAGGACGAGGTTCGCGCCCTGGGTGTCGAGCTGGGCCTGGCCCCGGCCTTCGTCGGCCGCCATCCGTTCCCCGGA
CCGGGCCTCGCCATCCGTATCCCGGGCGAGATCACGCCCGAGAAGGTCAAGGTCCTGCAGGACGCCGACGCCATCTATCT
GGAAGAGATCCGCAACGCCGGCCTCTATGACCAGATCTGGCAGGCCTTCGCGGTGCTGCTGCCCGTGAAGACGGTGGGCG
TGATGGGCGATGCGCGGACCTACGAGAACGTTCTGGCCCTGCGCGCGGTGACCTCGACCGACGGCATGACCGCCGACTTC
TTCGAGTTCCCGTGGCCGGTTCTGGGCAAGACCGCCACGCGCATCATCAACGAGGTGCGCGGCGTCAACCGCGTCGTCTA
TGACGTGACCAGCAAGCCGCCGGGCACGATTGAGTGGGAGTAG

Protein sequence :
MTQKTDHQRVLIVDFGSQVTQLIARRVREAGVYCEIHPFDKAEAIVDEYAPSAIILSGGPASVLEADSPRIGRKLFDLGL
PLLAICYGQQLLCDVLSGKVEGGHAGEFGRAELTIGKDSPMFQGLAGVGGVETVWMSHGDRVTAIPEGFEVIGTSTGAPF
AAIANDAKKIYALQFHPEVYHTVNGPAMYRNFLFNIAGLKGDWTMAAFRQEMVQKIRDQVGDGKVICGLSGGVDSSVAAV
LIHEAIGDQLTCVFVDTGLLRKNEADQVVTLFRDHYNIPLVHVDAGDLFLGELAGVSDPETKRKTIGRLFIDVFDKEAAK
IEGATFLAQGTLYPDVVESVSARGGPSAVIKSHHNVGGLPDYMKLKLVEPLRELFKDEVRALGVELGLAPAFVGRHPFPG
PGLAIRIPGEITPEKVKVLQDADAIYLEEIRNAGLYDQIWQAFAVLLPVKTVGVMGDARTYENVLALRAVTSTDGMTADF
FEFPWPVLGKTATRIINEVRGVNRVVYDVTSKPPGTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 1e-134 53
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 8e-135 53
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 7e-135 53
guaA NP_938969.1 GMP synthase Not tested Not named Protein 1e-120 52