Gene Information

Name : clpB (ML2490)
Accession : NP_302608.1
Strain : Mycobacterium leprae TN
Genome accession: NC_002677
Putative virulence/resistance : Virulence
Product : heat shock protein
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0542
EC number : -
Position : 2963220 - 2965766 bp
Length : 2547 bp
Strand : -
Note : -

DNA sequence :
GTGGACTCTTTCAACCCGACCACCAAAATGCAGGTGGCTCTAACTTCAGCGCTGCAGGCAGCGTCGTCCGCAGGTAATCC
CGAGATCAGACCTGTGCATTTGCTATTGGCGATGCTCATGCAAAACGACGGAATCGCCGCACCGTTGTTGGAGACTGTCG
GTGTGGAGCCCGACATCGTTCGCAATGAGGCACAGCGGCTCCTGGAGCGATTACCCCAGGCCAGCGGCTGCAGCTCGCAG
CCGCAGTTGTCGCGAGAGTCGTTGGCTGCCATCACCACCGCTCAGCAGCTCGCTACCGAGATGGACGACGAGTACGTGTC
GACCGAGCACCTGATGCTAGGGTTAGCCATGGGCGACTCCGATGTCGCGAAGCTGCTTACCGGGCACGGTGCCTCGCCGC
AGGTGTTACGGGAGGCGTTCGTCAAGATACGTGGCAGTGCCCGAGTCACTAGCTCCGATCCCGAGTTCACCTATCAAGCG
TTGGAGAAGTACTCCACAGATCTGACCGCCCAGTCCGGCGAAGGCAAACTTGACCCAGTTATCGGGCGCGACAACGAGAT
CCGTCGTGTTGTGCAGGTGCTGTCCCGTCGCACCAAGAACAACCCGGTGCTTATCGGCGAGCCTGGTGTCGGCAAGACCG
CGATCGTGGAGGGCTTGGCTCAGCGCATCGTTGCCGGCGATGTGCCGGAGAGCCTGCGTGACAAGACCTTGGTAGCGCTG
GATCTCGGGTCAATGGTGGCTGGCGCCAAGTATCGCGGCGAGTTCGAACAACGACTCAAGGTCGTGCTCGACGACATCAA
ATTCTCTGCTGGACAGATCATCACGTTTATCGATGAGTTGCACACTATCGTCGGAGCCGGTGCGACTGGTGAGTCGGCGA
TGGATGCTGGCAACATGATCAAGCCGATGCTGGCCCGTGGCGAATTGCGCCTGGTCGGCGCCACCACGCTTGACGAGTAC
CGCAGGTACATCGAGAAGGATGCAGCGCTGGAGCGGCGCTTCCAGCAGATCTTCGTCGGCGAGCCGTCGGTGGAGGACAC
TGTTGGCATCCTGCGTGGGCTGAAGGACCGTTACGAGGTGCACCACGGTGTGCGCATCACCGACTCTGCTCTGGTAGCTG
CGGCAGCCCTCTCCGACCGTTATATCACCGCCCGGTTCCTGCCGGACAAGGCCATCGACCTGGTCGACGAAGCGGCTAGC
CGGTTACGCATGGAGATCGACTCGCGGCCTGTCGAGATCGACGAGGTTGAGCGGCTGGTGCGTCGCTTCGAGATCGAAGA
GATGGCTCTTGTGAACGAAGAAGACGAAGCATCCAAGGAGCGTTTGGAGACGTTGCGTGCGGAACTGGCTGACCAGAAGG
AGCGGCTCGCCGAGCTAACCGCGAGGTGGCAGAATGAAAAGAACGCGATAGATGTCGTCCGAGAACTTAAGGAACAGTTG
GAGACGTTGCGCGGGGAATCCGAGCGTGCTGAGCGTGACGGTGACCTGGCCAAGGCCGCTGAGCTGCGGTATGGGCGCAT
CCCCGAGGTTGAAAAGAAGCTGGAAGCGGCGGTGCCGACGGCCCAGGCCCGCGAGGACGTGATGCTCAAGGAAGAGGTCG
GTCCTGACGATATCGCCAACGTGGTGTCAGCGTGGACCGGCATACCGGCTGGCCGGTTGTTGGAGGGCGAGACCGCCAAG
CTGCTGCGTATGGAGGACGAACTGGGCAAGCGTGTGGTCGGGCAGAAGAAGGCAGTGCACGCGGTCTCTGACGCGGTGCG
ACGCTCGCGGGCCGGGGTTGCCGACCCTAACCGGCCGACCGGCTCGTTTTTGTTTCTTGGCCCGACCGGTGTCGGCAAGA
CCGAGCTGGCCAAAGCACTGGCTGATTTCCTGTTTGACGACCAGCGCGCGATGGTCCGTGTGGACATGAGCGAGTACGGT
GAGAAGCATTCGGTGGCCCGTCTGGTGGGTGCACCGCCCGGCTACATTGGCCACGATCAGGGTGGTCAGCTGACCGAGGC
GGTGCGCCGACGGCCTTACACGGTGGTGCTTTTCGACGAGGTCGAAAAGGCCCACTCGGATGTCTTCGATGTGCTACTGC
AGGTGCTCGACGAAGGCCGTTTGACTGACGGGCAGGGCCGCACGGTCGACTTTCGCAACACGATCCCCATCTTGACCTCC
AACCTGGGGTCGGGCGGCAGCGAGGAGCAGGTAATGGCAGCGGTGCGCTCGGTGTTCAAGCCGGAGTTCATCAACCGCCT
CGACGACGTACTGATCTTCGACGGGCTCAACCCCGAAGAGTTGGTGCGGATTGTCGACATTCAGCTTGAGCAGCTTGGCA
AGCGGCTCGCGCAGCGGCGGCTTCAACTGGAGGTTTCGTTGCCGGCTAAGCGCTGGTTGGCACAGCACGGCTTCGATCCT
GTATACGGCGCCCGGCCATTGCGTCGACTGGTACAGCAAGCGATCGGCGATCAATTGGCTAAAATGCTGCTGGCCGGCGA
GGTGCATGACGGGGACACCCTTCCGGTCAACGTCAGACCCGACGGGGAGGCGTTGATCCTGGGCTGA

Protein sequence :
MDSFNPTTKMQVALTSALQAASSAGNPEIRPVHLLLAMLMQNDGIAAPLLETVGVEPDIVRNEAQRLLERLPQASGCSSQ
PQLSRESLAAITTAQQLATEMDDEYVSTEHLMLGLAMGDSDVAKLLTGHGASPQVLREAFVKIRGSARVTSSDPEFTYQA
LEKYSTDLTAQSGEGKLDPVIGRDNEIRRVVQVLSRRTKNNPVLIGEPGVGKTAIVEGLAQRIVAGDVPESLRDKTLVAL
DLGSMVAGAKYRGEFEQRLKVVLDDIKFSAGQIITFIDELHTIVGAGATGESAMDAGNMIKPMLARGELRLVGATTLDEY
RRYIEKDAALERRFQQIFVGEPSVEDTVGILRGLKDRYEVHHGVRITDSALVAAAALSDRYITARFLPDKAIDLVDEAAS
RLRMEIDSRPVEIDEVERLVRRFEIEEMALVNEEDEASKERLETLRAELADQKERLAELTARWQNEKNAIDVVRELKEQL
ETLRGESERAERDGDLAKAAELRYGRIPEVEKKLEAAVPTAQAREDVMLKEEVGPDDIANVVSAWTGIPAGRLLEGETAK
LLRMEDELGKRVVGQKKAVHAVSDAVRRSRAGVADPNRPTGSFLFLGPTGVGKTELAKALADFLFDDQRAMVRVDMSEYG
EKHSVARLVGAPPGYIGHDQGGQLTEAVRRRPYTVVLFDEVEKAHSDVFDVLLQVLDEGRLTDGQGRTVDFRNTIPILTS
NLGSGGSEEQVMAAVRSVFKPEFINRLDDVLIFDGLNPEELVRIVDIQLEQLGKRLAQRRLQLEVSLPAKRWLAQHGFDP
VYGARPLRRLVQQAIGDQLAKMLLAGEVHDGDTLPVNVRPDGEALILG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
STY0294 NP_454876.1 ClpB-like protein Not tested SPI-6 Protein 3e-99 42

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
clpB NP_302608.1 heat shock protein VFG0079 Protein 2e-152 44
clpB NP_302608.1 heat shock protein VFG2076 Protein 2e-107 44
clpB NP_302608.1 heat shock protein VFG2084 Protein 1e-107 42