Gene Information

Name : nrdF (ML1731)
Accession : NP_302193.1
Strain : Mycobacterium leprae TN
Genome accession: NC_002677
Putative virulence/resistance : Unknown
Product : ribonucleotide-diphosphate reductase subunit beta
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0208
EC number : 1.17.4.1
Position : 2090613 - 2091590 bp
Length : 978 bp
Strand : -
Note : B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE

DNA sequence :
TTGTTGACTGGGAAGATGAAGCTAATTGACCGCGTTTCGGCGATTAATTGGAACTGGCTGCAAGACGACAAGGACGCCGA
GGTCTGGGACCGGCTGACTGGAAACTTCTGGCTGCCCGAGAAGGTGCCGGTGTCCAACGATCTCCCGTCGTGGGGCACGC
TGACTGCTAGTGAAAAGCAGCTGACAATGCGGGTGTTCACCGGTTTGACGCTGCTCGACACGATCCAAGGCACGGTCGGA
GCGGTCAGCCTTATTCCTGATGCGCTAACGCCGCATGAGGAAGCCGTCTACACCAACATTGCATTCATGGAGTCGGTGCA
CGCCAAGAGCTACAGTTCGATCTTTTCCACGCTGTGCTCGACAGCGGAGATCGACGAAGCGTTTCGCTGGTCGGAGGAGA
ACAACAACCTGCAGCGCAAAGCTAAGATTGTGATGGAGTACTATCGAGGCGACGAACCGCTCAAGCGCAAGGTGGCCTCC
ACCTTGCTCGAAAGCTTCCTGTTTTACTCTGGGTTCTACCTGCCGATGTACTGGTCAAGTCGGGCCAAGCTGACCAACAC
CGCTGATATGATTCGGCTGATCATCCGCGACGAAGCAGTCCACGGTTACTATATCGGCTACAAATTTCAGCGTGGCTTGG
TGTTGGTCGACGACGCCAGGCGGGCAGAACTCAAGGAATACACCTACGAATTGCTCTTTGAGCTCTACGACAACGAGGTG
GAATACACCCAAGATCTCTACGACAGAGTCGGGTTGACCGAAGACGTCAAGAAGTTCTTGCGCTACAACGCAAATAAGGC
GTTGATGAACCTTGGCTACGAGGCGCTGTTCCCGCGGGACGAGACCGACGTGAACCCGGCGATCCTGTCGGCCTTGTCTC
CCAACGCCGATGAGAATCATGACTTTTTCTCCGGCTCGGGGTCGTCGTATGTGATCGGGAAAGCCGTCGTCACTGAGGAC
GAGGACTGGGACTTCTAA

Protein sequence :
MLTGKMKLIDRVSAINWNWLQDDKDAEVWDRLTGNFWLPEKVPVSNDLPSWGTLTASEKQLTMRVFTGLTLLDTIQGTVG
AVSLIPDALTPHEEAVYTNIAFMESVHAKSYSSIFSTLCSTAEIDEAFRWSEENNNLQRKAKIVMEYYRGDEPLKRKVAS
TLLESFLFYSGFYLPMYWSSRAKLTNTADMIRLIIRDEAVHGYYIGYKFQRGLVLVDDARRAELKEYTYELLFELYDNEV
EYTQDLYDRVGLTEDVKKFLRYNANKALMNLGYEALFPRDETDVNPAILSALSPNADENHDFFSGSGSSYVIGKAVVTED
EDWDF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
cur_1479 YP_001800873.1 ribonucleoside-diphosphate reductase subunit beta Not tested Not named Protein 3e-110 72