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Name : lysS (ML1393) Accession : NP_301991.1 Strain : Mycobacterium leprae TN Genome accession: NC_002677 Putative virulence/resistance : Unknown Product : lysyl-tRNA synthetase Function : - COG functional category : J : Translation, ribosomal structure and biogenesis COG ID : COG1190 EC number : 6.1.1.6 Position : 1671923 - 1675042 bp Length : 3120 bp Strand : - Note : catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA DNA sequence : GTGCTGGCGCTGTTAGCCGCCGCGCTAACCACGCGCAAACGCATCGCCTGGCTGCTGTTGCTCGGCAATATGGTGCTCGC CGCCGTGTTAAACGCTGTGGATATGGCAGCGAATGGCAACACCCCAGCCGAGACATTCGGCGAAAACCTCGGGTTCGCAG TGCATGTTGTTGCGATCTTGCTGCTGGTTTTGAGCTATCGGGAATTCTGGGCCAAAGTCCGCCGAGGCGCGCTGTTCAAA GCGGCTGCGGTGCTGGTTGCCGGAGACGTGATCGGGATACTGTTGTCTTTGGGCCTGGTCGAGCTGTTCCCCGGATCGCT AGCGCGGCAGGATCGCCTGCCGTATGTGGCCAATCGGGTGGTCGGATTCGCACTTGCCGATCCCGACCTCTTCAGCGGCA AACCGCACGTCTTACTCAACGCAATCTTCGGCTTGTTCGGCGCCCTCGCGTTGATCATGGCCACTATCGTGCTGTTTCAG TCCCAGCGTGCAGATAACGCCCTGACCGGCGAGGATGAGTCCGCCATCCGCGGGCTACTTGAGCTGTATGGCAAGAACGA CTCACTGGGTTACTTCGCCACCCGGCGCGATAAGTCGGTGATCTTCGCGCACAATGGCCGCGCGGCCATAACCTATCGAG TTGAGATAGGAGTCTGCCTAGCCAGCGGCGACCCAGTAGGCGATCCCGGGGCATGGCCGCAGGCCGTCGATGCGTGGTTA GAGCTTTGCCAGACGTACGGTTGGGCGCCCGGTGTGATGGGGGCCAGTTCACAGGGGGCCCAGGTATTTCGTAGGGCCGG CTTCAACGCCATAGAACTCGGCGACGAGGCGATCTTGCGGACTGCCGTTTACAAACTTTCCGGCCCCGACATGCGCGGAG TGCGCCAGGCGGTGACACGGGCACGCCGGGCCGGACTGACCGTACGCATTAGACGGCACAGCGACATCTCCGCCAACGAG ATGGCAGACACCATCGCGCGTGCTGACGCCTGGCGCGACACCGAATTCGAACGTGGCTTTTCGATGGCGCTGGGCCGGCT CGGCGATCCGGCTGATTCAGATTGCCTGCTGGTCGAAGCAGTGGACCGCGACGACCATGTCGTTGCGATACTGTCACTGG TCCCGTGGGGAACCACCGGCGTCTCGTTGGACGTGATGCGCCGTTCTCCACAATCACCCAACGGCACCATCGAACTCATG GTCAGCGAGCTAGCCCTCAAGGGCGAGACTCTTGGGATCGCCCGCATTTCGTTGAATTTTACGATGTTTCGCGCCGCGTT CGAGCAAGGTGCTCAACTCGGCGCTGGCCCAATTGCACGGTTGTGGCGGGGGCTGCTGTTGTTTTTCTCACGGTGGTGGC AGTTGGAGACGCTGTACCGCTCGAACATAAAATACCTTCCTGACTGGGTCCCTCGTTACGCCTGCTACGAGGACGCCCGG TTGATTCCGCGGGTGGGGGTTGCCTCGGTGATCGCCGAGGGTTTCCTTGTGTTACCGTTCAGCCGACGCGGCCGGGTGCA CACCGGCCATCATCCGGCTGTGCCAGCGCGGTTAGCAGAATCCGGGCTGCTGCACCACGATGGGTCGACTCCAGATGTCA GCGGATTGCAAACGGCGGACGTCGATTTGGAAGTAGCGAATTCCCGTATACCCGAACAGGTACGGGTGCGTCTGGCAAAA CTTAAGACATTGCAACTCAACGGTATTGACGCTTATCCGGTGGGACACCCGCCTAGCCACACAGTCGCCCAGGCTCTGGA TGCCGACGACGAAGGCACCGTCTCGATATCTGGACGCATATTGCGGATACGTGACTATGGCGGCGTGTTGTTTGCTCATG TGCGTGACTGGTCGGGCGAAATACAAGTGCTGCTGGATAATTTAGTGCTGGAGTGCTGCTGCATCGCAGATTTCACCGCA GCCATTGATCTGGGCGATATAGTCGAAATGACCGGGAACATGGGCTTCAGCAAAAACGGGACTCGCTCGTTGATAGTACG CAACTGGCGGCTGATCGGTAAATGCTTACGGCCGCTACCGAACAAATGGAAGGGGTTAACCGACCCAGAAGCCCGGGTGC GAACCCGTTATGTCGATCTGGCAGTCAATACCGAGTCCCGTAACCTGATCATGGCTCGCAGCTGCGTGTTGCGCTCGGTC AGGGAGATGCTGTTCGCTAAAGGATTTGTCGAAGTCGAGACCCCAATCCTGCAACAAATTCACGGCGGCGCCACTGCCCG GCCATTCGCCACTCGCATCAATACCTATGACATGGATCTGTTCCTACGCATTGCCCCGGAGCTCTATCTTAAGAGGCTGT GCATCGGGGGTGTAGAGCGGGTCTTCGAGCTGGGCCGGGCCTTCCGTAACGAGGGAGTAGACTTTAGTCACAATCCGGAG TTCACCTTGCTGGAGGCCTACCAGGCGCACGCAGACTACCTAATGTGGATCGACGGCTGCCGAGAATTGATCCAGAATGC CGCCGAAGCCGCGAACGGTACACAGACCCTAATGCGGCCGCGGATCGAGGGAGCAAGCGGAACCGCAAACCACCTCGAGC CGATCGACATCTCCGGCGTCTGGCCGGTGAAGACCGTGTACGAAGCAGTATCCGAAGCGCTCGGAGAATGTGTCGACACC AGCACTGAGTTGGCCACTCTGCGTAAATTGTCCGACGCCGCACACATACCTTATTGGCCACACTGGGATACTGGTGCGGT GGTTCTGAAGCTCTATGAGCACCTGGTTGAGAACCGAACCGATCAACCGACATTCTACATCGACTTTCCAACGTCCGTGT CACCGTTAACCCGGCCACATAGAAGTAAGCCCGGTGTCGCCGAGCGATGGGACCTGGTGGCGTGGGGTATAGAATTAGGT ACCGCCTACAGCGAACTAACCGACCCGGTAGAGCAGCGGCGTCGTCTGCACGAACAGTCCTTATTGGCCGTCGGCGGAAA CCCCGAAGCGATGGAGCTCGACGAAGACTTCCTACAAGCCATGGAATACGCTATGCCACCGACCGGCGGCCTGGGAATGG GCATAGACCGTCTCGTGATGTTAATCACCGGCCGCAGCATTCGCGAAACGCTACCGTTCCCACTGGCCAAGCCGCACTAG Protein sequence : MLALLAAALTTRKRIAWLLLLGNMVLAAVLNAVDMAANGNTPAETFGENLGFAVHVVAILLLVLSYREFWAKVRRGALFK AAAVLVAGDVIGILLSLGLVELFPGSLARQDRLPYVANRVVGFALADPDLFSGKPHVLLNAIFGLFGALALIMATIVLFQ SQRADNALTGEDESAIRGLLELYGKNDSLGYFATRRDKSVIFAHNGRAAITYRVEIGVCLASGDPVGDPGAWPQAVDAWL ELCQTYGWAPGVMGASSQGAQVFRRAGFNAIELGDEAILRTAVYKLSGPDMRGVRQAVTRARRAGLTVRIRRHSDISANE MADTIARADAWRDTEFERGFSMALGRLGDPADSDCLLVEAVDRDDHVVAILSLVPWGTTGVSLDVMRRSPQSPNGTIELM VSELALKGETLGIARISLNFTMFRAAFEQGAQLGAGPIARLWRGLLLFFSRWWQLETLYRSNIKYLPDWVPRYACYEDAR LIPRVGVASVIAEGFLVLPFSRRGRVHTGHHPAVPARLAESGLLHHDGSTPDVSGLQTADVDLEVANSRIPEQVRVRLAK LKTLQLNGIDAYPVGHPPSHTVAQALDADDEGTVSISGRILRIRDYGGVLFAHVRDWSGEIQVLLDNLVLECCCIADFTA AIDLGDIVEMTGNMGFSKNGTRSLIVRNWRLIGKCLRPLPNKWKGLTDPEARVRTRYVDLAVNTESRNLIMARSCVLRSV REMLFAKGFVEVETPILQQIHGGATARPFATRINTYDMDLFLRIAPELYLKRLCIGGVERVFELGRAFRNEGVDFSHNPE FTLLEAYQAHADYLMWIDGCRELIQNAAEAANGTQTLMRPRIEGASGTANHLEPIDISGVWPVKTVYEAVSEALGECVDT STELATLRKLSDAAHIPYWPHWDTGAVVLKLYEHLVENRTDQPTFYIDFPTSVSPLTRPHRSKPGVAERWDLVAWGIELG TAYSELTDPVEQRRRLHEQSLLAVGGNPEAMELDEDFLQAMEYAMPPTGGLGMGIDRLVMLITGRSIRETLPFPLAKPH |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| lysS1 | YP_005682181.1 | lysyl-tRNA synthetase | Not tested | PiCp 7 | Protein | 3e-162 | 43 |
| lysS1 | YP_005684273.1 | lysyl-tRNA synthetase | Not tested | PiCp 7 | Protein | 8e-163 | 43 |
| lysX | YP_003784331.1 | lysyl-tRNA synthetase | Not tested | PiCp 7 | Protein | 8e-163 | 43 |
| lysS1 | YP_005686365.1 | lysyl-tRNA synthetase | Not tested | PiCp 7 | Protein | 8e-163 | 43 |
