Gene Information

Name : rph (ML1174)
Accession : NP_301856.1
Strain : Mycobacterium leprae TN
Genome accession: NC_002677
Putative virulence/resistance : Unknown
Product : ribonuclease PH
Function : -
COG functional category : J : Translation, ribosomal structure and biogenesis
COG ID : COG0689
EC number : 2.7.7.56
Position : 1370968 - 1371747 bp
Length : 780 bp
Strand : +
Note : RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs

DNA sequence :
GTGTCCACACGAGCAGACGGTCGTCTTGATGACGAACTTCGCGCGGTGGTCATCACTCGCGGGTTCACCGAACATCCGGC
GGGTTCGGTGCTTATCGAATTCGGTCACACAAAAGTCATGTGCACCGCTAGTCCCACCGAGGGAGTGCCGCGCTGGCGGA
AGGGATCGGGTAAGGGGTGGCTCACCGCCGAGTACGCGATGCTGCCGTCGGCCACCCATACTCGTTCGGAACGCGAATCG
GTGAAAGGTCGGCTCAGCGGGCGCACACAGGAGATCAGCCGGCTGATCGGGCGGTCATTGCGGGCGTGCATCGATCTGGC
GGCGCTCGGGGAGAACACCATCGCCGTCGACTGCGACGTGTTGCAAGCCGACGGTGGTACTCGCACTGCGGCTGTCACCG
GCGCCTACGTGGCGTTGGCCGACGCGGTGACTTACCTGTCGGCTGCAGGCAGGTTATTAGATCCCAGGCCGTTATCGTGT
GCCATCGCTGCGGTCAGCGTTGGCGTGGTCGACGGCAGGATTCGGGTAGACCTGTCCTACGAGGAAGACTCGCGGGCCGA
GGTCGACATGAACGTCATCGCGACCGACACCGGGACGCTGGTGGAGATTCAGGGGACTGGTGAGGGCGCCACGTTCCCGC
GTTCGACGCTGGACAAGCTTCTTGATATGGCACTGGGTGCTTGCGACAAGTTATTCGTTGCACAGCGCGATGCGTTGGCG
CTGCCGTATCAGGGTATGTCCCCTGAGGGACCGCCACCGCCGAAGGCGTTCGGCAGCTGA

Protein sequence :
MSTRADGRLDDELRAVVITRGFTEHPAGSVLIEFGHTKVMCTASPTEGVPRWRKGSGKGWLTAEYAMLPSATHTRSERES
VKGRLSGRTQEISRLIGRSLRACIDLAALGENTIAVDCDVLQADGGTRTAAVTGAYVALADAVTYLSAAGRLLDPRPLSC
AIAAVSVGVVDGRIRVDLSYEEDSRAEVDMNVIATDTGTLVEIQGTGEGATFPRSTLDKLLDMALGACDKLFVAQRDALA
LPYQGMSPEGPPPPKAFGS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
rph YP_001800860.1 ribonuclease PH Not tested Not named Protein 5e-68 64