Gene Information

Name : guaA (PM0293)
Accession : NP_245230.1
Strain : Pasteurella multocida Pm70
Genome accession: NC_002663
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 334538 - 336109 bp
Length : 1572 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGAACAACATTCACAACCATAAAATTTTAATTTTGGACTTCGGTTCACAATATACCCAGTTGATTGCCCGCCGTGTACG
TGAAATTGGCGTGTACTGCGAACTTTGGGCATGGGATGTTTCCGAAGCCGATATTCGTGAGTTTAATCCAACTGGGATTA
TTCTTTCTGGTGGTCCTGAAAGTACCACTGAAGAAAACAGCCCACGAGCTCCCGAATACGTATTCAACGCCGGTGTACCC
GTATTAGGGATCTGTTATGGTATGCAAACCATGGCGATGCAACTAGGTGGTTTAACTGAAACTTCTACTCACCGAGAATT
TGGTTATGCATCAGTGAATCTAAAAGCAGCGGACGCGTTATTTGCTCAATTAAATGATGATGTCACAAGTTCACAGCCCA
AATTAGACGTTTGGATGAGCCATGGCGATAAAGTGACGCGTTTGCCAGATCATTTCCAAGTCACCGCAATGACCTCAACC
TGTCCAATTGCAGCTATGTCGGATGAACGTCGTCGTTTTTATGGTGTCCAATTCCACCCAGAAGTGACTCATACAAAAAG
CGGGCTTGAATTATTAACGAATTTTGTGGTGAAGATCTGTGGTTGTGAACGTAACTGGACACCAGAAAATATCATTGAAG
ATGCCGTTGCTCGTCTTAAAGCACAAGTGGGTGATGATGAAGTGATCTTAGGATTATCTGGTGGCGTTGACTCTTCTGTC
ACTGCACTACTCTTACATCGTGCGATTGGTAAAAACTTACACTGTGTTTTCGTAGATAACGGTTTATTACGTCTCAACGA
AGCGGAACAAGTGATGGAGATGTTTGGCGATAAATTTGGTTTAAACATTATCCACGTAAAAGCAGAAGATCGTTTCTTAG
ATGCGTTAAAAGGCATCGATGAGCCCGAAGCAAAACGTAAAATGATTGGTAAAGTCTTTGTGGATGTTTTTGATGATGAA
TCGAAAAAACTCACCAGCGTCAAATGGTTAGCCCAAGGCACGATTTATCCAGATGTTATTGAGTCTGCGGCAAGTAAAAC
AGGTAAAGCACATGTGATTAAATCACACCATAACGTCGGTGGTTTACCTGACTACATGAAGCTAGGACTTGTTGAACCAC
TTCGTGAATTATTTAAAGATGAAGTACGTAAAATTGGTTTAGCATTAGGTTTACCAGCCGAAATGTTAAATCGTCACCCA
TTCCCAGGACCTGGTTTAGGTGTCCGTGTTTTAGGTGAAATCAAAAAAGAATACTGTGATTTAGTCCGCCTTGCTGATGC
GATCTTTATGGAAGAGTTGCATGCTTCTGGTTGGTACTACAAAGTCAGCCAAGCCTTCACGGTATTTTTACCAGTAAAAT
CCGTAGGTGTCATGGGTGATGGGCGTAAATATGACTGGGTAGTTTCCCTCCGTGCAGTGGAAACAATCGATTTTATGACC
GCACATTGGGCACACCTGCCTTATGATCTCTTAGGTAAAATTTCCAATCGTATTATTAATGAAGTCAATGGGATTTCTCG
CGTTGTTTATGACGTTAGCGGTAAGCCGCCAGCAACAATTGAGTGGGAATAA

Protein sequence :
MNNIHNHKILILDFGSQYTQLIARRVREIGVYCELWAWDVSEADIREFNPTGIILSGGPESTTEENSPRAPEYVFNAGVP
VLGICYGMQTMAMQLGGLTETSTHREFGYASVNLKAADALFAQLNDDVTSSQPKLDVWMSHGDKVTRLPDHFQVTAMTST
CPIAAMSDERRRFYGVQFHPEVTHTKSGLELLTNFVVKICGCERNWTPENIIEDAVARLKAQVGDDEVILGLSGGVDSSV
TALLLHRAIGKNLHCVFVDNGLLRLNEAEQVMEMFGDKFGLNIIHVKAEDRFLDALKGIDEPEAKRKMIGKVFVDVFDDE
SKKLTSVKWLAQGTIYPDVIESAASKTGKAHVIKSHHNVGGLPDYMKLGLVEPLRELFKDEVRKIGLALGLPAEMLNRHP
FPGPGLGVRVLGEIKKEYCDLVRLADAIFMEELHASGWYYKVSQAFTVFLPVKSVGVMGDGRKYDWVVSLRAVETIDFMT
AHWAHLPYDLLGKISNRIINEVNGISRVVYDVSGKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 2e-130 54
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 2e-130 54
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 1e-130 54
guaA NP_938969.1 GMP synthase Not tested Not named Protein 1e-109 48