Gene Information

Name : sctN (TC_0040)
Accession : NP_296424.1
Strain : Chlamydia muridarum Nigg
Genome accession: NC_002620
Putative virulence/resistance : Virulence
Product : type III secretion cytoplasmic ATPase SctN
Function : -
COG functional category : N : Cell motility
COG ID : COG1157
EC number : -
Position : 44843 - 46171 bp
Length : 1329 bp
Strand : +
Note : similar to GB:J04038, GB:J02642, GB:M17851, GB:M33197, GB:X01677, GB:X53778, GB:M36164, GB:M28283, SP:P00354, SP:P04406, PID:182861, PID:182863, PID:182977, PID:182981, and PID:31645; identified by sequence similarity; putative

DNA sequence :
ATGAAAGAGCTAACGACCGAGTTTGATACGCTCATGACTGAATTGCCAGAAGTTCAATTGACGGCAGTTGTTGGGCGTAT
TATCGAAGTTGTCGGGATGTTAATCAAAGCTGTCGTTCCGGATGTTCGGGTGGGCGAAGTTTGCCTGGTGAAACGTCATG
GAATGGAGCCTTTGGTAACAGAGGTTGTCGGGTTTACGCAGAACTTTGTATTTCTCTCTCCTTTAGGAGAGTTATCTGGA
GTGAGTCCTTCTTCTGAAGTGATCGCCACGGGATTGCCTTTGCACATTCGAGCAGGGGCAGGACTTTTAGGCCGTGTATT
GAATGGTCTTGGAGAACCTATTGATATAGAGACCAAAGGACCTTTGGAGAATGTCGATTCCATTTATCCCATTTTTAAAG
CTCCACCAGATCCTTTGCATCGAGAAAAATTGCGTACGATTCTATCTACAGGAGTGCGTTGTATAGATGGAATGCTTACT
GTTGCCAAAGGACAAAGAATCGGGATTTTTGCGGGAGCAGGGGTCGGAAAATCTTCTTTGTTAGGCATGATTGCTCGTAA
CGCAGAAGAAGCCGATATTAACGTGATTGCGTTAATTGGAGAGCGGGGACGAGAAGTTCGGGAGTTTATAGAAAATGACC
TTGGTGAAGAAGGAATGAAACGTTCCGTCATTGTGGTATCTACTTCCGATCAATCTTCTCAGCTTCGATTGAACGCTGCT
TATGTGGGAACAGCTATAGCAGAATATTTTAGGGACCAGGGTAAGACAGTTGTGCTTATGATGGATTCTGTGACCCGGTT
TGCTCGAGCTTTACGGGAAGTAGGGCTCGCAGCTGGAGAGCCTCCTGCTCGTGCTGGGTATACTCCTTCCGTATTTTCAA
CATTGCCCAAATTATTGGAAAGAGCGGGAGCTTCGGAGAAAGGGACTATCACGGCATTTTATACCGTGTTAGTTGCTGGG
GATGATATGAATGAGCCGGTGGCTGATGAGGTGAAGTCTATTTTGGATGGGCATATCGTGCTTTCCAACGCGTTAGCTCA
AGCTTATCATTATCCTGCGATTGATGTGCTGGCTTCTATTAGCCGATTATTGACTGCAATTGTTCCTGAAGAACAACGTC
GAATTATTGGTCGTGCTAGGGAAGTCTTAGCGAAATATAAAGCGAACGAGATGTTGATTCGTATTGGGGAATATCGTCGA
GGGTCTGATCGTGAGGTAGATTTCGCGATTGACCATATTGATAAATTGAATCGTTTCCTCAAGCAAGATATTCATGAAAA
AACAAATTATGAGGAAGCTGCTCAGCAGTTGAGAGCAATATTCCGGTAA

Protein sequence :
MKELTTEFDTLMTELPEVQLTAVVGRIIEVVGMLIKAVVPDVRVGEVCLVKRHGMEPLVTEVVGFTQNFVFLSPLGELSG
VSPSSEVIATGLPLHIRAGAGLLGRVLNGLGEPIDIETKGPLENVDSIYPIFKAPPDPLHREKLRTILSTGVRCIDGMLT
VAKGQRIGIFAGAGVGKSSLLGMIARNAEEADINVIALIGERGREVREFIENDLGEEGMKRSVIVVSTSDQSSQLRLNAA
YVGTAIAEYFRDQGKTVVLMMDSVTRFARALREVGLAAGEPPARAGYTPSVFSTLPKLLERAGASEKGTITAFYTVLVAG
DDMNEPVADEVKSILDGHIVLSNALAQAYHYPAIDVLASISRLLTAIVPEEQRRIIGRAREVLAKYKANEMLIRIGEYRR
GSDREVDFAIDHIDKLNRFLKQDIHEKTNYEEAAQQLRAIFR

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
lscN AAO18044.1 LscN Virulence TTSS locus Protein 3e-110 54
hrpB6 AAF61281.1 HrpB6 Virulence Hrp PAI Protein 8e-104 54
hrcN YP_198730.1 type III secretion system ATPase Virulence Hrp PAI Protein 1e-103 54
hrpB6 BAB07852.1 HrpB6 Virulence Hrp PAI Protein 8e-104 54
XC_3006 YP_244074.1 type III secretion system ATPase Virulence Hrp PAI Protein 1e-102 53
hrcN NP_636610.1 type III secretion system ATPase Virulence Hrp PAI Protein 1e-102 53
hrcN AAP34339.1 HrcN Virulence Hrp PAI Protein 6e-104 53
hrcN YP_362163.1 type III secretion system ATPase Virulence Hrp PAI Protein 2e-102 53
hrcN NP_640767.1 type III secretion system ATPase Virulence Hrp PAI Protein 1e-102 53
hrpB6 AAB08461.1 HrpB6 Virulence Hrp PAI Protein 1e-102 53
ssaN NP_805086.1 type III secretion system ATPase Virulence SPI-2 Protein 5e-85 51
ssaN YP_216423.1 type III secretion system ATPase Virulence SPI-2 Protein 4e-85 51
ssaN NP_460380.1 type III secretion system ATPase Virulence SPI-2 Protein 3e-85 51
ssaN CAA70537.1 secretion system apparatus Virulence SPI-2 Protein 2e-85 51
ssaN NP_456113.1 putative type III secretion ATP synthase Virulence SPI-2 Protein 5e-85 51
YPO0267 YP_002345348.1 type III secretion system ATPase Virulence Not named Protein 4e-88 50
escN AFO66300.1 putative LEE-encoded type III secretion system ATPase Virulence SESS LEE Protein 2e-84 48
escN AFO66415.1 putative LEE-encoded type III secretion system ATPase Virulence SESS LEE Protein 2e-84 48
unnamed AAL06369.1 EscN Virulence LEE Protein 6e-86 48
hrcN AAG33879.1 HrcN Virulence Hrp PAI Protein 5e-80 47
escN CAC81862.1 EscN protein Virulence LEE II Protein 4e-88 47
ECs4568 NP_312595.1 EscN Virulence LEE Protein 8e-89 47
escN AAC38383.1 EscN Virulence LEE Protein 1e-88 47
escN AAC31513.1 L0034 Virulence LEE Protein 6e-89 47
unnamed ACU09458.1 type III secretion apparatus H+-transporting two-sector ATPase Virulence LEE Protein 6e-89 47
escN YP_003232153.1 T3SS structure protein EscN Virulence LEE Protein 6e-88 47
escN YP_003236088.1 translocator EscN Virulence LEE Protein 5e-88 47
escN AAK26715.1 EscN Virulence LEE Protein 1e-87 47
escN YP_003223475.1 translocator EscN Virulence LEE Protein 5e-88 47
escN AAL57542.1 EscN Virulence LEE Protein 1e-87 47
escN CAI43874.1 EscN protein Virulence LEE Protein 4e-88 47
escN NP_290268.1 hypothetical protein Virulence LEE Protein 8e-89 47
hrcN NP_791227.1 type III secretion cytoplasmic ATPase HrcN Virulence Hrp PAI Protein 1e-81 47
hrcN AAT96141.1 HrcN Virulence T-PAI Protein 1e-82 47
hrcN AAT96195.1 HrcN Virulence T-PAI Protein 9e-83 47
ECs3730 NP_311757.1 ATP synthase SpaL Not tested LIM Protein 1e-72 46
hrcN AAR25633.1 type III secretion cytoplasmic ATPase HrcN Not tested Not named Protein 6e-77 46
hrcN ABQ88354.1 HrcN Virulence Hrp PAI Protein 4e-77 46
hrpJ4 AAA81942.1 HrpJ4 Virulence Hrp PAI Protein 4e-77 46
hrcN ABA47275.1 HrcN Virulence S-PAI Protein 2e-89 46
hrcN AAB06001.1 HrcN Virulence Hrp PAI Protein 5e-89 46
ysaN AAS66842.1 YsaN Not tested SSR-1 Protein 5e-73 45
hrcN AAT96258.1 HrcN Virulence S-PAI Protein 2e-83 45
hrcN AAT96339.1 HrcN Virulence S-PAI Protein 5e-83 45
hrcN AAT96299.1 HrcN Virulence S-PAI Protein 3e-83 45
invC AAS66861.1 InvC Not tested SSR-2 Protein 7e-71 43
invC YP_217813.1 ATP synthase SpaL Virulence SPI-1 Protein 2e-67 43
spaI NP_457288.1 secretory apparatus ATP synthase (associated with virulence) Virulence SPI-1 Protein 2e-67 43
spaI NP_806497.1 ATP synthase SpaL Virulence SPI-1 Protein 2e-67 43
invC NP_461815.1 ATP synthase SpaL Virulence SPI-1 Protein 2e-67 43

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
sctN NP_296424.1 type III secretion cytoplasmic ATPase SctN VFG2144 Protein 0.0 98
sctN NP_296424.1 type III secretion cytoplasmic ATPase SctN VFG0192 Protein 2e-115 57
sctN NP_296424.1 type III secretion cytoplasmic ATPase SctN VFG0048 Protein 5e-115 55
sctN NP_296424.1 type III secretion cytoplasmic ATPase SctN VFG0390 Protein 5e-110 55
sctN NP_296424.1 type III secretion cytoplasmic ATPase SctN VFG0515 Protein 1e-85 51
sctN NP_296424.1 type III secretion cytoplasmic ATPase SctN VFG0730 Protein 6e-89 47
sctN NP_296424.1 type III secretion cytoplasmic ATPase SctN VFG0812 Protein 3e-89 47
sctN NP_296424.1 type III secretion cytoplasmic ATPase SctN VFG2331 Protein 3e-83 46
sctN NP_296424.1 type III secretion cytoplasmic ATPase SctN VFG1254 Protein 2e-86 46
sctN NP_296424.1 type III secretion cytoplasmic ATPase SctN VFG1008 Protein 3e-68 45
sctN NP_296424.1 type III secretion cytoplasmic ATPase SctN VFG2499 Protein 2e-81 45
sctN NP_296424.1 type III secretion cytoplasmic ATPase SctN VFG2459 Protein 2e-73 44
sctN NP_296424.1 type III secretion cytoplasmic ATPase SctN VFG1778 Protein 1e-73 44
sctN NP_296424.1 type III secretion cytoplasmic ATPase SctN VFG0555 Protein 7e-68 43