Gene Information

Name : cvrA; nhaP2; ycgO (BH4038)
Accession : NP_244906.1
Strain : Bacillus halodurans C-125
Genome accession: NC_002570
Putative virulence/resistance : Unknown
Product : potassium/proton antiporter
Function : -
COG functional category : P : Inorganic ion transport and metabolism
COG ID : COG3263
EC number : -
Position : 4175502 - 4176974 bp
Length : 1473 bp
Strand : -
Note : the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli

DNA sequence :
ATGGACTTTCACACAGATACGATTATCCTTCTGGCAGGGCTCTTGTTCATTGTGGGTGTCATCACAGCTAAGTTCTCCAC
TCGATTAGGTGTGCCCGCTCTCGTCTTGTTTATTCTCGTCGGTATGCTTGTTGGCAGCGACGGGCTAGGCCTCATTCATT
TTGATTTTAGTCAAGCACATTTTGCCCAACTCATCGGGATCTTCGCCCTTGTCATCATTTTGTTTGAAGGAGGGTTACAG
ACGAAATGGAAAACGGTCCAATCGGTAGCGGTGCCATCGCTCTCCCTTGCCACGTTCGGTGTTTTGATCACTTCCACATT
GGTGGCGGTTGCGGCGAAGTACGTCCTTGGCGTAAGCTGGCTTGAGGCGTATTTATTCGGGGCGATTGTTGGGTCAACCG
ATGCTGCAGCGGTTTTTGCTGTATTAAAGGAACAAAACATTAAAGACCGTCTCGCCACCACATTAGAGGCAGAGTCAGGG
ACGAACGATCCAATGGCCGTCTTTTTAACGCTCTCCCTTATTGAATTGATTACGATCGGTTCCATGAACCCGCTCCACTT
ATTCGGCTCCTTCCTATGGCAAATGGGGGCAGGGCTCATTCTTGGATTCGGACTTGGCAAGCTAGGGTCTTACTCGATTA
ATAAAATTAACCTTGATTCCAGTGGACTTTATCCTGTGTTTGCTCTTGCGTTTGCCTTGCTCACGTACAGTGTGACCGCG
ATGATTGGAGCGAGTGGGCTGCTCGCGGTTTACGTAGCGGCTCTTGTGATCGGCAACCAAGACTTGACGTATCGACATTC
GATTTTCCGCTTTAACGAAGGGTTTGCGTGGATGATGCAAATGCTCATGTTCATCATTCTCGGACTCCTTGTTTTTCCGA
ATCAACTGTTTGAAGCATCCATCTTTATTAAAGGTATCCTTCTTTCCCTCATTTTAATGCTTGTGGCTCGGCCGGTTGCC
GTGTTCCTCACAACCATTAAGATGAGGTTCGATTGGAAAGAAAAGCTCTTTCTGTCTTGGGCTGGCTTGCGTGGTGCGGT
TCCAATTGTATTAGCGACCTTTCCGATGACAGCAGGCCTCGAAAACAGTCCGTTGTTTTTCAATGTCGTGTTTTTCGTCG
TCCTCACCTCAGCCCTTATCCAAGGTTCTACTATCGCCCATTTTGCCAATAAACTGCAGCTAACGGGGCCACAAAAAACG
ACCCCTTTGCATTCCCTTGAGCTTGTGTCGATCGGGAAGGCGAACGCGGAAATTGTGGAGCTTGAGATGAAACAGGATAC
TCCCGTAATCGGAAAAACATTGGAGGAAATCAACTTGCCGAAGGATGTGCTCGTCAATGCGATTATTCGAGACGAACAGC
TCATTACGCCATATGGTAAAACGACGATCCAAGCGGATGATATTTTATATGTCCTCGTATCAAAGAAAAAGAAAAGGCAG
CTAAAGGAATTGTTCCAAGCGAAGGAAAGCTAA

Protein sequence :
MDFHTDTIILLAGLLFIVGVITAKFSTRLGVPALVLFILVGMLVGSDGLGLIHFDFSQAHFAQLIGIFALVIILFEGGLQ
TKWKTVQSVAVPSLSLATFGVLITSTLVAVAAKYVLGVSWLEAYLFGAIVGSTDAAAVFAVLKEQNIKDRLATTLEAESG
TNDPMAVFLTLSLIELITIGSMNPLHLFGSFLWQMGAGLILGFGLGKLGSYSINKINLDSSGLYPVFALAFALLTYSVTA
MIGASGLLAVYVAALVIGNQDLTYRHSIFRFNEGFAWMMQMLMFIILGLLVFPNQLFEASIFIKGILLSLILMLVARPVA
VFLTTIKMRFDWKEKLFLSWAGLRGAVPIVLATFPMTAGLENSPLFFNVVFFVVLTSALIQGSTIAHFANKLQLTGPQKT
TPLHSLELVSIGKANAEIVELEMKQDTPVIGKTLEEINLPKDVLVNAIIRDEQLITPYGKTTIQADDILYVLVSKKKKRQ
LKELFQAKES

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
unnamed AAB61290.1 unknown Not tested PAI I CFT073 Protein 4e-55 42
f536 AAC61706.1 F536 Not tested PAI I CFT073 Protein 4e-55 42