Gene Information

Name : thyA (BH3451)
Accession : NP_244318.1
Strain : Bacillus halodurans C-125
Genome accession: NC_002570
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 3563500 - 3564294 bp
Length : 795 bp
Strand : -
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGGAACAATATTTAGAGCTTTGCCGCCACGTTCTCGAGCATGGAACCGAGCGATCAGACCGGACAGGAACAGGGACGAT
CAGCGTTTTTGGCTATCAGATGAGATTTGATCTCCAAGAAGGATTTCCCGTTGTTACGACGAAAAAACTGCACCTGCGGT
CGATCATCCATGAACTGCTTTGGTTTTTAAAAGGAGAGACTAACATCGCCTACTTGCAAGAGAATGGTGTGCGAATTTGG
AACGAGTGGGCCGATGAAAATGGGGAACTTGGTCCTGTATATGGTAAGCAGTGGCGCTCATGGGAAGGAGCGAATGGGAA
AACGGTCGACCAAATTTCTCAAGTCGTAGAAGCGATTAAACATCAACCGGATTCAAGACGATTGATCGTAAGTGCTTGGA
ATGCAGCGGAGATTGAAGATATGGCCTTGGCTCCATGTCATTGTCTATTCCAATTTTATGTGCAAGATGGAAAGCTATCG
TGTCAGCTCTATCAGCGAAGTGCAGACATTTTCCTAGGCGTACCTTTCAACATCGCTTCATACGCCTTGTTAACAAAAAT
GATCGCCCAAGTATGCGATTTAGAAGAAGGAGAGTTTGTTCACACGTTCGGTGACGCTCACATTTACTTAAATCATATCG
AACAAGTAAAATTACAGTTAACGAGAGAGCCAAGACCATTACCGGAGATGCGTTTGAACCCAGAGGTTCGTTCATTGTTC
GACTTCACGTTCGATGATTTTGAACTTGTCGGATATGATCCGCACCCTCATATAAAAGGAGAAGTGTCTGTATGA

Protein sequence :
MEQYLELCRHVLEHGTERSDRTGTGTISVFGYQMRFDLQEGFPVVTTKKLHLRSIIHELLWFLKGETNIAYLQENGVRIW
NEWADENGELGPVYGKQWRSWEGANGKTVDQISQVVEAIKHQPDSRRLIVSAWNAAEIEDMALAPCHCLFQFYVQDGKLS
CQLYQRSADIFLGVPFNIASYALLTKMIAQVCDLEEGEFVHTFGDAHIYLNHIEQVKLQLTREPRPLPEMRLNPEVRSLF
DFTFDDFELVGYDPHPHIKGEVSV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_001800914.1 thymidylate synthase Not tested Not named Protein 1e-81 62