Gene Information

Name : pykA (BH3163)
Accession : NP_244029.1
Strain : Bacillus halodurans C-125
Genome accession: NC_002570
Putative virulence/resistance : Virulence
Product : pyruvate kinase
Function : -
COG functional category : G : Carbohydrate transport and metabolism
COG ID : COG0469
EC number : 2.7.1.40
Position : 3279969 - 3281723 bp
Length : 1755 bp
Strand : -
Note : catalyzes the formation of phosphoenolpyruvate from pyruvate

DNA sequence :
ATGCGAAAGACAAAAATCGTTTGTACGATCGGTCCGGCGAGTGAAAGTGTAGAAAAGTTAGAACAATTAATGGAAGCAGG
CATGAATGTTGCGCGGTTAAATTTTTCCCATGGGGACTTTGAAGAGCACGGTGCACGAATCAAAAACATTCGAGAAGCAG
CGAAACGTATCGGAAAAACAGTTGCAATTTTACTTGATACAAAAGGACCGGAAATTCGTACCCAAACCCTTGAAGGGGGC
GTGGCCGAATTAAAGGCAGGGCAAGAGCTTGTCATCTCTATGAAGGAGGTTGTAGGTACGAGTGAGCGTATTTCTGTCAC
ATATCCGGGCCTAGTTCATGATGTTGTACCAGGTGCAAAAATTTTATTAGATGATGGGTTAATTGGGCTAGAAGTCGTTG
AGGTTCGCGATCAAGAGATTTTGACAAAAGTCTTGAACAGCGGCACATTGAAAAATAAAAAAGGTGTCAATGTCCCGAAC
GTAAGCGTCAACCTGCCTGGAATCACAGAAAAAGACGCAGCGGATATCAAGTTTGGGATAGAGCAAGGCGTCGATTTCAT
TGCAGCTTCATTCGTTCGCAGAGCGCAAGATGTACTAGAAATTCGCGAATTGCTTGAGCAGCACGGGGCAGAGCATATTA
AAATCATCCCTAAGATCGAGAATCAAGAAGGCGTTGATAACATCGAGGAAATTCTTGAAGTATCAGACGGTTTGATGGTG
GCCCGCGGAGATCTAGGGGTAGAGATTCCTGCTGAGGAAGTTCCACTTGTGCAAAAGTCGCTTATTAAGAAATGCAACCT
TGTAGCTAAACCTGTTATTACAGCGACACAGATGCTTGACTCGATGCAGCGTAACCCACGTCCAACTCGAGCCGAAGCTA
GTGATGTAGCGAATGCGATTTTTGATGGAACGGATGCGATCATGCTTTCCGGTGAAACCGCAGCTGGGGATTATCCAGTC
GAGGCGGTTCAGACGATGAGCCGAATTGCAGAGCGTGCAGAGCAAGCCCTAAACTATCAAGAAATCTTGTCCAAGCATAC
AAAAGAAGCGAGAACGACGATTACGAGTGCTATTAGTCAATCGGTTGGCCACACAGCATTCAACTTGAATGCAAGTGCAA
TCTTGACGGCGACTGAAAGCGGCCATACAGCTCGCGTAGTAGCGAAATACCGCCCGAAATCACCAATTGTAGCAGTTACA
AGTAACGAAACAGTTGTTCGTCAACTCGCTCTCGTTTGGGGAGTGTATTCAATCCTTGGAGAAGAGGCAGAGACGACGGA
TGATATGCTTCAAGTGACCGTTGAGACAGCGTTAAAGTCCCAATTGGTGAAACAAGGGGATCTTGTCGTCATCACGGCAG
GTGTTCCAGTGGGAGAGACAGGAACGACGAACATTATGAAAGTTCACGTCATTGGTGAAGTGGTCGCGAAAGGTCAAGGC
ATTGGACGCGACACGGTGAACGGCAAAGTCGTCATTGCTGCTAATGCAGAGGAAGCAAATGCAAAGGTTGAAGAAGGGTC
GATTTTAGTTACTTTCAGCACGGATAAGGATATGATGCCAGCCTTTGAAAAAGCAGCCGCCGTCATTACCGAAGAAGGTG
GGATTACATCCCATGCCGCAGTTGTTGGTCTAAGTCTTAATACACCTGTGATCGTCGGTGTACAAAATGCGTCTGCGCTC
TTTAAAGATGGGGAAGAAATAACGGTCGATACGAGCCGCGGTGACATTTACAGAGGGCAAGCAAGTGTACTATAA

Protein sequence :
MRKTKIVCTIGPASESVEKLEQLMEAGMNVARLNFSHGDFEEHGARIKNIREAAKRIGKTVAILLDTKGPEIRTQTLEGG
VAELKAGQELVISMKEVVGTSERISVTYPGLVHDVVPGAKILLDDGLIGLEVVEVRDQEILTKVLNSGTLKNKKGVNVPN
VSVNLPGITEKDAADIKFGIEQGVDFIAASFVRRAQDVLEIRELLEQHGAEHIKIIPKIENQEGVDNIEEILEVSDGLMV
ARGDLGVEIPAEEVPLVQKSLIKKCNLVAKPVITATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGDYPV
EAVQTMSRIAERAEQALNYQEILSKHTKEARTTITSAISQSVGHTAFNLNASAILTATESGHTARVVAKYRPKSPIVAVT
SNETVVRQLALVWGVYSILGEEAETTDDMLQVTVETALKSQLVKQGDLVVITAGVPVGETGTTNIMKVHVIGEVVAKGQG
IGRDTVNGKVVIAANAEEANAKVEEGSILVTFSTDKDMMPAFEKAAAVITEEGGITSHAAVVGLSLNTPVIVGVQNASAL
FKDGEEITVDTSRGDIYRGQASVL

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
pykF YP_216386.1 pyruvate kinase Not tested SPI-2 Protein 1e-117 55
pykF NP_805051.1 pyruvate kinase Not tested SPI-2 Protein 1e-117 55
STY1744 NP_456147.1 pyruvate kinase Not tested SPI-2 Protein 1e-117 55
pykF CAA68205.1 pyruvate kinase like protein Not tested SPI-2 Protein 2e-117 55

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
pykA NP_244029.1 pyruvate kinase VFG0479 Protein 5e-118 55