Gene Information

Name : arsB (PA2278)
Accession : NP_250968.1
Strain : Pseudomonas aeruginosa PAO1
Genome accession: NC_002516
Putative virulence/resistance : Resistance
Product : arsenite-antimonite efflux pump ArsB
Function : -
COG functional category : P : Inorganic ion transport and metabolism
COG ID : COG1055
EC number : -
Position : 2506978 - 2508261 bp
Length : 1284 bp
Strand : +
Note : Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

DNA sequence :
ATGCTGATCGCCTTCGCCATCTTCCTGTTCACCCTGGTCCTGGTCATCTGGCAGCCCAGGGGCCTCGGCATCGGCTGGAG
CGCCAGCATCGGTGCCCTGCTCGCCCTGGCGCTGGGCAGCGTCGCGCCGGGCGACATCCCGACCGTCTGGAACATCGTCT
GGAATGCCACCGCCACCTTCATCGCGGTGATCGTCATCAGCCTGCTGCTGGACGAGGCCGGCTTCTTCGAATGGGCCGCG
CTGCACGTCGCGCGCTGGGCTGGCGGCGACGGCCGGCGCCTGTTCGCCTTCTGCGTGCTGCTCGGCGCGGCGGTCTCGGC
GCTGTTCGCCAACGACGGCGCGGCGCTGATCCTCACGCCCATCGTGATGTCGATGCTGCTGGCCCTGCGCTTCAGCCCGG
CGGCGACCCTGGCCTTCGTCATGGCGGCGGGCTTCATCGCCGACAGCGCCAGCCTGCCGCTGGTGGTCTCGAACCTGGTG
AACATCGTCTCGGCCGACTACTTCGGGCTCGGCTTCGGCGAGTACGCCGCGGTCATGCTGCCGGTAAACCTGGTGAGCGT
CGCGACCTCCCTGCTGGTGCTGTTCCTCTATTTCCGCCGCGACCTGCCGCCGGTCTATGCGCTGGAGCAATTGAAGCCGC
CGCGGGCGGCGATCCGCGACCGCGCGACCTTCGTCGTCGGTGGCTGGATGCTGCTGGTCCTGCTCGCCGGGCTGTTCGCC
CTGGAGCCGCTGGGCGTCCCCGTCAGCGCGGTGGCCGCGGCCTGTGCGGCGCTGCTGCTGGCGGTGGCCGGGCGCGGGCG
GGTGATCTCGACCCGGCGGGTGCTGCGCGAAGCGCCCTGGCAGATCGTGGTCTTCTCGCTGGGCATGTACCTGGTGGTCT
ACGGCCTGAAGAACGCCGGTCTCACCGACCTCCTGGCGCAGCTCCTGAACCGCCTGGCCGAGCACGGCGTATGGGCGGCC
GCGCTGGGTACCGGACTGCTTTCCGCCGCCCTCTCGTCGGTAATGAACAACATGCCCAGCATGCTGCTCGGCGCCCTGTC
GATCCAGGCCAGCGACACCGCCGGCGCGGTGCGCGAAGCGATGATCTACGCCAACGTCATCGGCTGCGACCTGGGTCCGA
AGATCACCCCTATCGGCAGCCTGGCGACGCTGCTCTGGCTGCACGTGCTGGCGCGCAAAGGCATGCGCATCACCTGGGGC
TACTACTTCAGGGTCGGCGCCCTGCTGACCCTGCCGGTCCTGCTGGCGACCCTTTCGGCCCTGGCCCTGCGCCTGGCCAT
CTGA

Protein sequence :
MLIAFAIFLFTLVLVIWQPRGLGIGWSASIGALLALALGSVAPGDIPTVWNIVWNATATFIAVIVISLLLDEAGFFEWAA
LHVARWAGGDGRRLFAFCVLLGAAVSALFANDGAALILTPIVMSMLLALRFSPAATLAFVMAAGFIADSASLPLVVSNLV
NIVSADYFGLGFGEYAAVMLPVNLVSVATSLLVLFLYFRRDLPPVYALEQLKPPRAAIRDRATFVVGGWMLLVLLAGLFA
LEPLGVPVSAVAAACAALLLAVAGRGRVISTRRVLREAPWQIVVFSLGMYLVVYGLKNAGLTDLLAQLLNRLAEHGVWAA
ALGTGLLSAALSSVMNNMPSMLLGALSIQASDTAGAVREAMIYANVIGCDLGPKITPIGSLATLLWLHVLARKGMRITWG
YYFRVGALLTLPVLLATLSALALRLAI

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
arsB2 YP_001007633.1 arsenical pump membrane protein Not tested YAPI Protein 2e-110 71
arsB YP_252017.1 arsenical pump membrane protein Not tested SCCmec Protein 5e-87 53
arsB YP_005754065.1 arsenical pump membrane protein Not tested Type-XI SCCmec Protein 5e-85 53
SH0109 YP_252024.1 arsenical pump membrane protein Not tested SCCmec Protein 1e-87 53

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
arsB NP_250968.1 arsenite-antimonite efflux pump ArsB BAC0578 Protein 6e-112 72
arsB NP_250968.1 arsenite-antimonite efflux pump ArsB BAC0576 Protein 1e-111 71
arsB NP_250968.1 arsenite-antimonite efflux pump ArsB BAC0031 Protein 1e-112 71
arsB NP_250968.1 arsenite-antimonite efflux pump ArsB BAC0577 Protein 7e-107 70
arsB NP_250968.1 arsenite-antimonite efflux pump ArsB BAC0574 Protein 2e-87 53
arsB NP_250968.1 arsenite-antimonite efflux pump ArsB BAC0575 Protein 1e-87 52