Gene Information

Name : guaA (VC0768)
Accession : NP_230417.1
Strain :
Genome accession: NC_002505
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 821588 - 823141 bp
Length : 1554 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGACTAAAAATATTCATGACCAACGAATTCTGATCCTCGATTTCGGATCTCAATATACCCAGCTAGTAGCCCGTCGCGT
GCGCGAGATCGGTGTGTACTGTGAGCTGTGGAGCTGGGATGTAGAAGAGGCGGACATTCGCGAATTCAATCCTGACGGCA
TTATTCTTTCGGGGGGACCTGAAAGCGTGACCGAAGCTAATTCACCACGTGCCCCGCAATATGTGTTTGACAGTGGTGTG
CCTGTCTTTGGTGTTTGCTACGGCATGCAGACCATGGCTGAGCAGTTAGGAGGCCGTGTTGCGACTTCTGATGAGCGTGA
ATTTGGTTATGCTCAGGTAAAAATTTCTGGCGAATCGGCGCTATTTAAAGATCTCGATCTCACGCAAGACGTTTGGATGA
GCCACGGTGACAAAGTGGTCGAAATCCCAGCGGATTTCGTGAAAATCGGTGAGACCGATACCTGCCCATACGCTGCGATG
GCCAATGAAGAGAAGAAATACTACGGCGTGCAGTTCCACCCCGAAGTGACACACACCAAAAACGGTTTACAGATGCTGGA
GAACTTTGTTCTGGGCGTGTGTGGCTGTGAGCGTCTGTGGACGTCTGAATCCATCATCGAAGATGCGGTTGCTCGCATCA
AAGAACAAGTGGGTAACGATGAAGTGATCCTTGGCCTGTCGGGCGGTGTCGATTCTTCTGTGGTTGCCATGCTGGTTCAC
CGTGCGATTGGAAGTAAGCTCACTTGTGTGTTCGTGGACAACGGACTACTTCGTTTAAACGAAGGCGAGCAAGTGATGGA
GATGTTTGGTGATAAATTTGGCCTCAACATCATTAAAGTCGATGCAGAAGAGCGCTTCCTAAAAGCGCTAGAAGGCATTG
ATGAGCCTGAAGCAAAACGCAAAACCATCGGCCGTGTGTTTGTTGAAGTATTTGATGAAGAATCGAAAAAACTCAGCAAC
GCAAAATGGTTGGCGCAAGGCACCATCTATCCAGATGTGATTGAATCTGCCGCTTCAAAAACCGGTAAAGCGCATGTGAT
CAAATCGCACCACAACGTGGGCGGTTTACCTGATGACATGAAAATGGGCTTGGTTGAGCCACTGCGTGAACTGTTTAAAG
ATGAAGTGCGCAAGATTGGCCTTGAGCTTGGTTTACCTTACAACATGCTTTACCGCCACCCATTCCCAGGCCCAGGCCTT
GGTGTGCGTGTACTGGGTGAAGTGAAGAAAGAGTACTGTGATTTATTGCGTCGTGCAGATGCAATCTTTATTGAAGAGCT
GCACGCAGCGGATCTGTACAACAAAGTTTCTCAAGCCTTTACTGTGTTCTTGCCAGTGCGTTCAGTTGGTGTCATGGGCG
ATGGCCGTAAGTACGATTGGGTTGTGTCATTGCGCGCAGTCGAAACCATCGACTTTATGACCGCACATTGGGCACATCTA
CCTTATGAGTTCTTGGGTAAGGTTTCCAACCGCATTATCAACGAAGTGAATGGCATTTCTCGCGTAGTGTATGACATCTC
AGGTAAGCCACCAGCGACCATTGAGTGGGAATAA

Protein sequence :
MTKNIHDQRILILDFGSQYTQLVARRVREIGVYCELWSWDVEEADIREFNPDGIILSGGPESVTEANSPRAPQYVFDSGV
PVFGVCYGMQTMAEQLGGRVATSDEREFGYAQVKISGESALFKDLDLTQDVWMSHGDKVVEIPADFVKIGETDTCPYAAM
ANEEKKYYGVQFHPEVTHTKNGLQMLENFVLGVCGCERLWTSESIIEDAVARIKEQVGNDEVILGLSGGVDSSVVAMLVH
RAIGSKLTCVFVDNGLLRLNEGEQVMEMFGDKFGLNIIKVDAEERFLKALEGIDEPEAKRKTIGRVFVEVFDEESKKLSN
AKWLAQGTIYPDVIESAASKTGKAHVIKSHHNVGGLPDDMKMGLVEPLRELFKDEVRKIGLELGLPYNMLYRHPFPGPGL
GVRVLGEVKKEYCDLLRRADAIFIEELHAADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDFMTAHWAHL
PYEFLGKVSNRIINEVNGISRVVYDISGKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 1e-131 52
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 1e-131 52
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 8e-132 52
guaA NP_938969.1 GMP synthase Not tested Not named Protein 8e-115 49