Gene Information

Name : guaA (XF2429)
Accession : NP_299708.1
Strain : Xylella fastidiosa 9a5c
Genome accession: NC_002488
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 2311167 - 2312735 bp
Length : 1569 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGACGCCGAATATTCATCACGACAAAATTCTTATCCTCGATTTCGGCGCACAGTACACCCAGTTGATTGCCCGTCGTAT
CCGTGAAATTGGTGTCTACTGCGAAGTGTGGCCCTGGGATCACTCCCCTGAAGAGATTTTGAGCTTCGGAGCCAAAGGTA
TCATCCTCTCCGGTGGCCCTGAATCGACAACATCCCCGGGTGCGCCTGCAGCACCGCAGCACGTCTTTGATAGTGACTTA
CCAATCCTCGGTATTTGCTATGGCATGCAAACCATGGCCGTACATCTTGGGGGTGCGACCGAGGCAGCCGACAAACGCGA
GTTTGGTCATGCCTCGGTCCAGGTGATTTACCCGGATACCTTGTTTTCCGGCTTGTCCGATCATCCCTCTGAGTTCCGTC
TGGATGTGTGGATGAGTCATGGTGACCATGTTTCACGCGTCCCGCCCGGCTTCACCATTACAGCCGCCACTGACCGCATC
CCCATTGCGGCGATGAGTCGCGAAGATAAGCGCTGGTATGGCGTGCAATTCCATCCGGAAGTGACCCATACCTTACAGGG
ACAGGCTTTATTGCGCCGTTTTGTGGTTGATATATGTGGCTGCCAGATGTTATGGACCGCTGCTAACATCATTGAAGACC
AAATTGCTCATGTGCGTGAACGTGTCGGTTGCGATGAAGTCATTCTCGGCCTGTCCGGTGGCGTTGATTCTTCCGTCGTC
GCGGCTCTCTTACAGAAAGCCATTGGCAGCCAACTGACGTGTGTATTTGTTGATACTGGCCTGCTTCGCTGGGGAGAAGG
CGACCAAGTGATGGCCATGTTTGCGGAACATATGGGCGTCAACGTGGTACGTATCAATGCGGCATCGCGTTACTTCGACG
CACTGCAAGGTGTCTACGACCCAGAAGCCAAACGCAAAATCATCGGCAACCTGTTCATCCAGATATTCGAGGAAGAGGCA
AGCAAACGAAAGCAGGCCAAATGGTTGGCACAAGGCACGATTTATCCGGATGTGATCGAATCGGCCGGCAGCAAAACCGG
CAAAGCCCACGTGATCAAAAGCCATCACAACGTCGGCGGCTTGCCGGAGCAGATGACCCTGGGTATGGTCGAACCATTAC
GTGAATTGTTCAAAGATGAAGTGCGCCGCCTTGGCGTTGCTCTGGGCCTGCCCCATGCCATGGTATATCGCCATCCATTC
CCAGGACCTGGCTTGGGCGTGCGTATCCTCGGTGAAGTCAAGCCGGAGTATGCCGAGTTACTGGCCAAGGCTGACGCGAT
TTTTATTGATGAACTTCATCAAGCCGACCTGTACGACAAGGTTAGCCAAGCCTTTGCAGTCTTTCTTCCGGTGAAATCAG
TCGGCGTTGTTGGTGATGCCCGTGCGTATGAATGGGTGATTGCACTGCGCGCGGTTGAGACCGTTGATTTCATGACGGCA
CAGTGGGCGCCACTGCCGTATGACTTCCTGAGTACCGTCTCCAACCGCATCATCAATGAACTACGCGGCGTGTCCCGCGT
GGTCTACGATATTTCCGGAAAGCCGCCAGCGACGATTGAGTGGGAGTGA

Protein sequence :
MTPNIHHDKILILDFGAQYTQLIARRIREIGVYCEVWPWDHSPEEILSFGAKGIILSGGPESTTSPGAPAAPQHVFDSDL
PILGICYGMQTMAVHLGGATEAADKREFGHASVQVIYPDTLFSGLSDHPSEFRLDVWMSHGDHVSRVPPGFTITAATDRI
PIAAMSREDKRWYGVQFHPEVTHTLQGQALLRRFVVDICGCQMLWTAANIIEDQIAHVRERVGCDEVILGLSGGVDSSVV
AALLQKAIGSQLTCVFVDTGLLRWGEGDQVMAMFAEHMGVNVVRINAASRYFDALQGVYDPEAKRKIIGNLFIQIFEEEA
SKRKQAKWLAQGTIYPDVIESAGSKTGKAHVIKSHHNVGGLPEQMTLGMVEPLRELFKDEVRRLGVALGLPHAMVYRHPF
PGPGLGVRILGEVKPEYAELLAKADAIFIDELHQADLYDKVSQAFAVFLPVKSVGVVGDARAYEWVIALRAVETVDFMTA
QWAPLPYDFLSTVSNRIINELRGVSRVVYDISGKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 4e-123 51
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 3e-123 51
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 3e-123 51
guaA NP_938969.1 GMP synthase Not tested Not named Protein 4e-111 49