Gene Information

Name : XF1776 (XF1776)
Accession : NP_299064.1
Strain : Xylella fastidiosa 9a5c
Genome accession: NC_002488
Putative virulence/resistance : Unknown
Product : DNA topoisomerase I
Function : -
COG functional category : L : Replication, recombination and repair
COG ID : COG0550
EC number : -
Position : 1694565 - 1696424 bp
Length : 1860 bp
Strand : -
Note : catalyzes the ATP-dependent breakage of signle-stranded DNA followed by passage and rejoining, maintains net negative superhelicity

DNA sequence :
ATGACGCGGCGCTCAAGCGCTGGTCGCTGGAGCAGTTGCCCATTGTTCCGCAGCAGTGGCGGGTCGAGGTCAAACCGAAG
ACCGCCACGCAATTCTAAGGTCGTCAAGGCGCTTCTGGCGAAGGCGACCCATCTGGTCATCGCCACCGATGCCGACCGTG
AGGGCGAGCTGATCGCCCGCGAGATCATCGACCTGTGCGGCTACCGCGGCCCCATCGAGCGGCTATGGCTGTCGGCGCTC
AACGATGCGTCGATCCGCACCGCGCTCGGCAAGTTGCGGCCCTCATCCGACACGCTGCCGATGTACTACTCGGCGCTTGC
GCGCTCACGCGCCGACTGGCTCGTGGGCATGAACCTCAGCCGGTTGTTCACGGTGCTCGGGCTTCAGGCCGGCTACGACG
GCGTGCTGTCCGTCGGTCGCGTCCAGACGCCGACCTTGAAGCTCGTCGTGGACCGCGACCGCGAGATCGCGGCCTTCAAG
TCGGTGCCGTTCTGGGCCATCGACGTGTCCCTGTCCGCGGGCGGTCAGGCTTTCAGCGCGCAGTGGGTTCCGCCAGATGG
CTGCACCGACGATGCCGGCCGCTGCCTGCAGCAGCCTATCGCCCAGCAGGCCGCGCAGCAGATCCGCGCTGCGAGCAGCG
CCCAGGTCGTGTCAGTCGAGACCGAGCGCGTGCGCGAAGGGCCACCGCTGCTGTTCGACCTGGGAACGCTTCAGGAGGTT
TGTTCCAAGCAGCTTGGGCTGGATGTGCAGGAGACGCTGGAGATCGCCCAGGCCCTCTATGAGACCCATAAAGCCACCAC
GTACCCGCGTTCCGATTCGGGCTACCTGCCCGAAAGCATGTTCGCCGAGGTGCCGACTGTTCTGGACAGCCTGCTCAAGA
CCGACCCCTCGCTGCGCCCGATCATGGGCCAGCTCGACCGCTCCCAGCGCTCGCGCGCCTGGAACGACGGCAAAGTGACG
GCGCACCACGGCATCATTCCCACCTTGGAACCCGCGAACCTCTCGGCGATGAGCGAGAAGGAACTGGCGGTGTACCGGCT
GATCCGCGCGCACTACCTGGCGCAGTTCCTCCCTCACCACGAGTTCGACCGCACGATCGCCGAGCTGTCCTGCGGCCAGC
AGAAGCTGGTGGCCACCGGAAAGCAGGTGGCCGCCCAGGGTTGGCACCTGGTGCTGGCCGAGCCGCAAGCGGACGAGGAC
GGGGAAACCACCGCGCGCAGCCAGGTACTCCCCGCGCTGCGCGAGGGCCTGGCATGCCAAGTGGCCGAGGCCGAAGTCAA
GGCGCTCAAGACGCTGCCTCCGAAGCCCTATACCCAGGGCGAACTGGTCAAGTCGATGAAAGGCGTGGCGCGCTTCGTGA
CCGACCCGCGCCTGAAGCAGAAGTTGAAGGACACGACGGGCATTGGCACCGAAGCCACGCGCGCCAACATCATCACCGGC
CTGCTGACGCGGGGCTATCTCGTGAAGAAAGGACGCTCCATTCGCGCATCGGATGCGGCATTCACGTTGATCGACGCTGT
GCCCGCGGCGATTGCCGACCCCGGAACCACCGCCGTGTGGGAGCAGGCGCTCGACATGATCGAGGCCGGACAGCTCACCC
TGGATGTGTTCATCGGCAAGCAGGCCGCATGGATTTCGCAACTGATCGTGCAGTACGGCAGCACCTCGCTGTCCATCAAG
GTTCCCCAGGGTCCCGCTTGCCCGCAGTGCGGCGCACCGACGCGCCAGCGCACCGGCAAGACCGGCCCCTTCTGGTCGTG
CAGTCGCTACCCCGACTGCAAAGGCACGCTGCCGGTCGATTCCGGCACGTCCAAGCGCGGTGCCTCGCGCCCGCGCAGTA
GCGGCCGCAAGGGCTCCTGA

Protein sequence :
MTRRSSAGRWSSCPLFRSSGGSRSNRRPPRNSKVVKALLAKATHLVIATDADREGELIAREIIDLCGYRGPIERLWLSAL
NDASIRTALGKLRPSSDTLPMYYSALARSRADWLVGMNLSRLFTVLGLQAGYDGVLSVGRVQTPTLKLVVDRDREIAAFK
SVPFWAIDVSLSAGGQAFSAQWVPPDGCTDDAGRCLQQPIAQQAAQQIRAASSAQVVSVETERVREGPPLLFDLGTLQEV
CSKQLGLDVQETLEIAQALYETHKATTYPRSDSGYLPESMFAEVPTVLDSLLKTDPSLRPIMGQLDRSQRSRAWNDGKVT
AHHGIIPTLEPANLSAMSEKELAVYRLIRAHYLAQFLPHHEFDRTIAELSCGQQKLVATGKQVAAQGWHLVLAEPQADED
GETTARSQVLPALREGLACQVAEAEVKALKTLPPKPYTQGELVKSMKGVARFVTDPRLKQKLKDTTGIGTEATRANIITG
LLTRGYLVKKGRSIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFIGKQAAWISQLIVQYGSTSLSIK
VPQGPACPQCGAPTRQRTGKTGPFWSCSRYPDCKGTLPVDSGTSKRGASRPRSSGRKGS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
topB AAN62194.1 putative DNA topoisomerase III Not tested PAGI-2(C) Protein 0.0 89
topB AAN62317.1 putative DNA topoisomerase III Not tested PAGI-3(SG) Protein 0.0 77
pph56 CAI36097.1 Topoisomerase IA Not tested PPHGI-1 Protein 0.0 61
PMI2630 YP_002152332.1 DNA topoisomerase III Not tested Not named Protein 5e-143 50
topB1 YP_005176228.1 DNA topoisomerase III Not tested ICEPmu1 Protein 3e-143 50
topB NP_458624.1 topoisomerase B Not tested SPI-7 Protein 2e-139 48
topB NP_807836.1 DNA topoisomerase III Not tested SPI-7 Protein 2e-139 48
topB AAF14809.1 topoisomerase B Not tested SPI-7 Protein 1e-139 48