Gene Information

Name : pyk (BB_0348)
Accession : NP_212482.1
Strain : Borrelia burgdorferi B31
Genome accession: NC_001318
Putative virulence/resistance : Virulence
Product : pyruvate kinase
Function : -
COG functional category : G : Carbohydrate transport and metabolism
COG ID : COG0469
EC number : 2.7.1.40
Position : 357007 - 358440 bp
Length : 1434 bp
Strand : +
Note : identified by match to protein family HMM PF00224; match to protein family HMM PF02887; match to protein family HMM TIGR01064

DNA sequence :
ATGATTTCAAAGTTAACAAAAATTGTAGCAACAATATCTGATCTTAGATGCGAACCAGAACATATAAAAGATTTACACGA
TGCAGGGGTAAATGTTATAAGACTAAATACTGCTCATCAATCACACGAAGATACAATAAAAGTAATAGACAATGTTAGAA
AAATTTCAAATAAAATAGCTTTAATGATTGATACAAAAGGACCAGAAGTTAGAACAGCAAATATTGAAAATCCTATTATT
GTAAAAACTGGAGACAAGGTAATCATTTCAACCTCGCCTATTAATGAGCCTAATAACTTTCAAACCAATTATGATGGATT
TGTTAAAGAAGTACCCCAAGGATCTAAAGTGCTAATTGATGACGGTGAACTTGAAATGACTGTTGTTGCCAAATTGCCTG
ACAGATTAATTTGTGAAATTAAAAATGACGGCCAAATTAAAAATAAAAAATCAATCAATACCCCCGGAATTTCTCTTAAG
CTACAATCAGTAACCGAAAAAGACAAAGGATTTATTGAGCTTGCAGCAAAATATAATGTTGATTTTATTGCCCATTCGTT
TGTAAGACATTCCAAAGACGTTCAAGATGTTCAAGAAATTTTAACTGCCTCTGGAAATCCTGATGTAAAAATTATATCCA
AAATCGAAAATCAAGAGGGAATTGACAACATTGAAGAAATTGCAAAAGCTTCTTACGGAATAATGGTTGCAAGGGGAGAC
ATGGGAGTTGAAATTCCTGCAGAAGATGTACCCATTGCTCAACTTAAAATAACACAAACCTGTATAAAGTATGGAATACC
CGTGATTACAGCAACTCAAATGCTTCATACAATGATTGAAAATCCAAGACCTACTAGAGCAGAAGTGTCTGACATCGCTA
ACGCTATTTTAAACGGCACAGACGCAATTATGTTATCCGGAGAAACCGCCTACGGGAAATATCCAATTGAAGCTGTAAAA
ATGATGACAAGCATTGCTAAAAAAGTTGAAAAACACAGAAAAATGACCTTATATAAGGATGAACTTTTTTACGATAAAAG
TATCACAAGAAACTATATTATCAAATGTGCAATTGATGCCACAAAACTTATGGACATAAAAGCAATTATTGTAGATTCTC
TAAAAGGCAAAACCGCAAGAATAATGGCAACCTACAGAGCAAGTGTTCCATTATTCATTACAACAAATAGCGAAAGACTA
GCAAGAGAATTAGCATTATCTTACGGGGTTTATTCTAATCTTGTAGACAATAATTTCAAAAGAACTACCGAATTTGTAGT
AACTTCTCTTAAAATGTTAAAAGAACAAGGTGTTGTTAATGACAAAGATACTGTAATAATTATTTCTGGAAATCCAAATA
GAAATATTGAAAAAGGAACAGAATTTATGGAAATAAACACAGTAGAAGATGCAATCAAAGGACGAAATATATAA

Protein sequence :
MISKLTKIVATISDLRCEPEHIKDLHDAGVNVIRLNTAHQSHEDTIKVIDNVRKISNKIALMIDTKGPEVRTANIENPII
VKTGDKVIISTSPINEPNNFQTNYDGFVKEVPQGSKVLIDDGELEMTVVAKLPDRLICEIKNDGQIKNKKSINTPGISLK
LQSVTEKDKGFIELAAKYNVDFIAHSFVRHSKDVQDVQEILTASGNPDVKIISKIENQEGIDNIEEIAKASYGIMVARGD
MGVEIPAEDVPIAQLKITQTCIKYGIPVITATQMLHTMIENPRPTRAEVSDIANAILNGTDAIMLSGETAYGKYPIEAVK
MMTSIAKKVEKHRKMTLYKDELFYDKSITRNYIIKCAIDATKLMDIKAIIVDSLKGKTARIMATYRASVPLFITTNSERL
ARELALSYGVYSNLVDNNFKRTTEFVVTSLKMLKEQGVVNDKDTVIIISGNPNRNIEKGTEFMEINTVEDAIKGRNI

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
pykF CAA68205.1 pyruvate kinase like protein Not tested SPI-2 Protein 2e-67 41
STY1744 NP_456147.1 pyruvate kinase Not tested SPI-2 Protein 9e-68 41
pykF YP_216386.1 pyruvate kinase Not tested SPI-2 Protein 3e-68 41
pykF NP_805051.1 pyruvate kinase Not tested SPI-2 Protein 3e-68 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
pyk NP_212482.1 pyruvate kinase VFG0479 Protein 1e-68 41