Gene Information

Name : yrhB (BSU27250)
Accession : NP_390603.1
Strain : Bacillus subtilis 168
Genome accession: NC_000964
Putative virulence/resistance : Resistance
Product : cystathionine gamma-lyase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 4.4.1.8
Position : 2785001 - 2786140 bp
Length : 1140 bp
Strand : -
Note : catalyzes the formation of L-homocysteine from cystathionine

DNA sequence :
ATGAAGAAAAAAACATTGATGATACATGGCGGAATCACAGGTGATGAGAAAACAGGCGCAGTTTCCGTGCCGATTTATCA
AGTAAGCACGTACAAGCAGCCGAAAGCAGGGCAGCATACAGGCTACGAGTATTCAAGAACGGCCAATCCGACTCGAACCG
CTCTCGAAGCACTTGTGACAGAACTGGAAAGCGGGGAAGCAGGCTATGCGTTCAGCTCAGGAATGGCTGCCATTACAGCG
GTTATGATGCTGTTTAACAGCGGAGATCATGTCGTGTTGACTGATGATGTGTACGGCGGAACATATCGCGTGATGACAAA
GGTGCTTAACCGTCTTGGCATTGAATCAACATTTGTTGATACGAGCAGCAGGGAAGAAGTTGAAAAAGCGATTCGCCCTA
ATACAAAAGCAATTTATATTGAAACACCGACAAACCCGTTGCTCAAAATCACCGACCTGACGCTCATGGCTGATATCGCA
AAAAAAGCGGGTGTTCTGCTTATCGTAGACAATACCTTTAATACTCCTTATTTTCAACAGCCGCTTACTTTAGGCGCTGA
TATCGTACTGCACAGTGCGACAAAATATCTTGGCGGACACAGTGATGTCGTCGGAGGTTTAGTTGTGACAGCTTCGAAAG
AGCTTGGAGAAGAGCTGCATTTTGTGCAAAACTCCACAGGCGGCGTGCTCGGCCCTCAAGATTCCTGGCTGTTAATGAGA
GGAATCAAAACGTTGGGACTCAGAATGGAAGCGATCGATCAAAATGCGCGGAAAATCGCAAGCTTTCTTGAGAATCACCC
TGCTGTCCAAACGTTATATTACCCTGGTTCTTCAAATCATCCCGGACATGAGCTTGCAAAAACGCAAGGAGCGGGCTTCG
GCGGCATGATCTCCTTTGATATTGGCAGTGAAGAACGGGTTGATGCGTTTTTAGGAAATCTGAAACTGTTTACCATTGCT
GAAAGCCTGGGGGCGGTTGAAAGCTTAATTTCTGTTCCTGCAAGAATGACACATGCCTCTATTCCGAGAGAACGCCGGCT
TGAGCTCGGCATTACGGACGGCTTGATCAGAATTTCTGTAGGAATTGAAGATGCGGAAGACTTGTTGGAAGATATCGGCC
AAGCGCTTGAAAATATATAA

Protein sequence :
MKKKTLMIHGGITGDEKTGAVSVPIYQVSTYKQPKAGQHTGYEYSRTANPTRTALEALVTELESGEAGYAFSSGMAAITA
VMMLFNSGDHVVLTDDVYGGTYRVMTKVLNRLGIESTFVDTSSREEVEKAIRPNTKAIYIETPTNPLLKITDLTLMADIA
KKAGVLLIVDNTFNTPYFQQPLTLGADIVLHSATKYLGGHSDVVGGLVVTASKELGEELHFVQNSTGGVLGPQDSWLLMR
GIKTLGLRMEAIDQNARKIASFLENHPAVQTLYYPGSSNHPGHELAKTQGAGFGGMISFDIGSEERVDAFLGNLKLFTIA
ESLGAVESLISVPARMTHASIPRERRLELGITDGLIRISVGIEDAEDLLEDIGQALENI

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 5e-109 59
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 1e-107 58
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 1e-77 45

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
yrhB NP_390603.1 cystathionine gamma-lyase BAC0207 Protein 1e-68 44