Gene Information

Name : thyA (BSU21820)
Accession : NP_390065.1
Strain : Bacillus subtilis 168
Genome accession: NC_000964
Putative virulence/resistance : Unknown
Product : thymidylate synthase 2
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 2297106 - 2297900 bp
Length : 795 bp
Strand : -
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGAAACAGTATAAGGATTTCTGCAGACATGTTTTAGAGCATGGTGAGAAAAAGGGAGACCGGACTGGGACCGGAACAAT
CAGCACTTTCGGATATCAAATGAGATTTAATTTACGGGAAGGCTTTCCGATGCTCACCACTAAAAAACTCCACTTTAAAT
CAATTGCGCATGAACTGCTGTGGTTCTTAAAAGGAGATACGAATGTACGCTATCTGCAGGAAAACGGAGTGCGAATCTGG
AATGAGTGGGCTGATGAAAACGGTGAACTTGGACCTGTATATGGCTCCCAATGGCGTTCTTGGCGGGGAGCTGATGGAGA
AACCATTGATCAAATTTCCCGTCTTATTGAAGATATTAAAACAAATCCGAACTCCAGACGCTTAATCGTCAGCGCCTGGA
ATGTTGGTGAAATTGATAAAATGGCGTTGCCGCCGTGCCATTGCCTGTTCCAATTCTATGTGTCTGACGGCAAGCTGTCC
TGTCAGCTGTATCAGCGCTCTGCCGATGTTTTCTTAGGTGTGCCGTTTAATATTGCATCTTATGCCCTCCTAACCATGAT
CATTGCTCATGTGACTGGGCTTGAACCGGGCGAGTTCATCCATACGTTTGGTGATGTTCATATTTACCAAAATCATATTG
AACAAGTCAATTTGCAGCTGGAAAGAGATGTTAGACCGCTTCCGCAGCTTCGTTTCGCCAGAAAGGTTGATTCTATTTTT
AACTTTGCATTTGAGGACTTTATCATCGAGGATTATGATCCGCATCCTCATATAAAAGGGGCGGTCAGCGTATGA

Protein sequence :
MKQYKDFCRHVLEHGEKKGDRTGTGTISTFGYQMRFNLREGFPMLTTKKLHFKSIAHELLWFLKGDTNVRYLQENGVRIW
NEWADENGELGPVYGSQWRSWRGADGETIDQISRLIEDIKTNPNSRRLIVSAWNVGEIDKMALPPCHCLFQFYVSDGKLS
CQLYQRSADVFLGVPFNIASYALLTMIIAHVTGLEPGEFIHTFGDVHIYQNHIEQVNLQLERDVRPLPQLRFARKVDSIF
NFAFEDFIIEDYDPHPHIKGAVSV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_001800914.1 thymidylate synthase Not tested Not named Protein 8e-81 66
thyA YP_189147.1 thymidylate synthase Not tested ¥ÕSP¥â Protein 2e-54 45