Gene Information

Name : clpC (BSU00860)
Accession : NP_387967.1
Strain : Bacillus subtilis 168
Genome accession: NC_000964
Putative virulence/resistance : Virulence
Product : negative regulator of genetic competence ClpC/MecB
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0542
EC number : -
Position : 103572 - 106004 bp
Length : 2433 bp
Strand : +
Note : Evidence 1a: Function experimentally demonstrated in the studied strain; PubMedId: 12354604, 15529410, 16525504; Product type f: factor

DNA sequence :
ATGATGTTTGGAAGATTTACAGAACGAGCTCAAAAAGTACTGGCGCTAGCACAGGAAGAAGCACTTCGGTTAGGTCATAA
TAACATTGGCACTGAGCATATTTTATTAGGACTGGTAAGAGAAGGAGAGGGCATTGCTGCTAAAGCTCTTCAAGCGCTTG
GACTCGGTTCAGAAAAAATTCAGAAAGAAGTAGAAAGTTTGATCGGGCGCGGGCAGGAAATGTCTCAAACGATTCATTAT
ACTCCTAGAGCTAAAAAAGTCATTGAGCTTTCAATGGATGAGGCAAGAAAACTCGGTCATTCTTATGTGGGAACAGAACA
TATTCTTCTTGGTCTGATTCGTGAAGGAGAAGGTGTTGCTGCGAGAGTTCTGAATAATCTCGGTGTCAGCTTAAATAAAG
CAAGACAGCAGGTGCTCCAGCTTCTAGGAAGTAATGAAACAGGATCATCAGCGGCAGGAACAAACAGCAATGCGAATACG
CCTACGCTTGACAGCTTGGCAAGAGACTTAACTGCTATTGCGAAGGAAGACAGCCTTGACCCTGTAATCGGCAGAAGCAA
GGAGATCCAGCGTGTCATTGAAGTGTTAAGCCGCAGAACGAAAAACAACCCTGTTCTCATTGGGGAACCAGGTGTAGGTA
AAACGGCTATCGCAGAAGGTTTGGCACAGCAAATTATCAATAATGAAGTACCCGAAATTTTGCGTGATAAACGTGTGATG
ACATTAGACATGGGAACAGTTGTTGCCGGCACAAAATACCGCGGAGAATTTGAGGATCGCCTGAAGAAGGTCATGGATGA
AATTCGCCAGGCAGGAAATATCATTCTATTCATCGATGAGCTCCATACATTAATCGGGGCAGGCGGAGCAGAAGGTGCTA
TTGATGCATCTAATATTTTAAAACCTTCACTTGCTCGTGGCGAACTCCAATGTATTGGTGCAACGACTCTTGATGAGTAC
CGTAAATATATTGAAAAAGATGCAGCACTGGAACGCCGTTTTCAGCCGATTCAGGTTGATCAGCCATCTGTAGATGAAAG
TATTCAAATTTTACAAGGTCTGCGTGACAGATACGAAGCCCACCACCGCGTTTCTATCACTGATGATGCCATTGAAGCTG
CGGTTAAGCTTTCTGACAGATATATTTCTGACCGCTTCCTTCCGGATAAAGCAATTGACTTGATCGATGAAGCGGGTTCA
AAGGTGAGACTGCGCTCATTTACAACGCCTCCTAACTTAAAAGAGCTTGAGCAGAAGCTTGATGAGGTTCGTAAAGAGAA
GGATGCGGCAGTGCAAAGCCAAGAGTTTGAAAAAGCTGCTTCCTTGCGTGATACTGAACAACGCCTGCGCGAGCAAGTAG
AGGATACGAAGAAATCATGGAAAGAGAAGCAAGGGCAGGAAAACTCAGAGGTTACTGTGGATGATATTGCGATGGTTGTA
TCCAGCTGGACCGGTGTGCCTGTATCTAAAATCGCCCAAACTGAAACTGATAAGCTTCTCAATATGGAAAACATTCTTCA
CTCCCGTGTCATCGGCCAGGATGAAGCAGTTGTAGCGGTTGCAAAAGCCGTCAGACGTGCAAGAGCAGGATTGAAAGATC
CTAAACGCCCAATCGGCTCATTCATTTTCTTAGGCCCTACAGGTGTAGGTAAAACAGAACTTGCACGAGCACTTGCTGAA
TCCATTTTTGGCGATGAAGAATCCATGATCAGAATTGATATGTCTGAATACATGGAAAAACATTCAACTTCAAGACTTGT
TGGTTCACCTCCGGGTTATGTGGGATATGATGAAGGCGGTCAATTGACAGAGAAAGTCAGAAGAAAACCTTACTCTGTCG
TGCTTCTTGATGAGATCGAGAAAGCGCACCCTGATGTCTTCAATATCCTTCTGCAAGTTCTTGAAGACGGACGATTGACT
GATTCTAAAGGACGCACAGTCGATTTCCGCAATACCATTCTGATCATGACATCAAACGTCGGAGCAAGTGAGCTAAAACG
CAATAAATATGTCGGCTTTAACGTTCAGGATGAAACTCAAAATCATAAAGACATGAAAGATAAAGTGATGGGTGAATTAA
AACGAGCGTTCAGACCTGAGTTCATCAACCGTATTGATGAAATCATTGTCTTCCATTCACTTGAGAAAAAACATCTCACT
GAGATTGTGTCATTAATGTCTGATCAATTAACGAAACGCCTGAAAGAACAAGATCTTTCTATCGAATTGACAGATGCTGC
AAAAGCGAAAGTCGCGGAAGAGGGCGTTGACCTGGAATACGGTGCCCGTCCGTTAAGAAGAGCGATCCAAAAACATGTCG
AGGATCGTTTATCTGAAGAACTCCTCAGAGGAAATATTCATAAAGGACAGCATATTGTTCTTGATGTAGAAGATGGCGAA
TTTGTCGTAAAAACGACTGCTAAAACGAATTAA

Protein sequence :
MMFGRFTERAQKVLALAQEEALRLGHNNIGTEHILLGLVREGEGIAAKALQALGLGSEKIQKEVESLIGRGQEMSQTIHY
TPRAKKVIELSMDEARKLGHSYVGTEHILLGLIREGEGVAARVLNNLGVSLNKARQQVLQLLGSNETGSSAAGTNSNANT
PTLDSLARDLTAIAKEDSLDPVIGRSKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIAEGLAQQIINNEVPEILRDKRVM
TLDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNIILFIDELHTLIGAGGAEGAIDASNILKPSLARGELQCIGATTLDEY
RKYIEKDAALERRFQPIQVDQPSVDESIQILQGLRDRYEAHHRVSITDDAIEAAVKLSDRYISDRFLPDKAIDLIDEAGS
KVRLRSFTTPPNLKELEQKLDEVRKEKDAAVQSQEFEKAASLRDTEQRLREQVEDTKKSWKEKQGQENSEVTVDDIAMVV
SSWTGVPVSKIAQTETDKLLNMENILHSRVIGQDEAVVAVAKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALAE
SIFGDEESMIRIDMSEYMEKHSTSRLVGSPPGYVGYDEGGQLTEKVRRKPYSVVLLDEIEKAHPDVFNILLQVLEDGRLT
DSKGRTVDFRNTILIMTSNVGASELKRNKYVGFNVQDETQNHKDMKDKVMGELKRAFRPEFINRIDEIIVFHSLEKKHLT
EIVSLMSDQLTKRLKEQDLSIELTDAAKAKVAEEGVDLEYGARPLRRAIQKHVEDRLSEELLRGNIHKGQHIVLDVEDGE
FVVKTTAKTN

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
clpC YP_005163377.1 ATP-dependent Clp protease ATP-binding subunit Not tested Not named Protein 0.0 58

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
clpC NP_387967.1 negative regulator of genetic competence ClpC/MecB VFG0079 Protein 0.0 79
clpC NP_387967.1 negative regulator of genetic competence ClpC/MecB VFG0080 Protein 2e-152 52