Gene Information

Name : hemC (RP466)
Accession : NP_220846.1
Strain : Rickettsia prowazekii Madrid E
Genome accession: NC_000963
Putative virulence/resistance : Unknown
Product : porphobilinogen deaminase
Function : -
COG functional category : H : Coenzyme transport and metabolism
COG ID : COG0181
EC number : 2.5.1.61
Position : 580529 - 581428 bp
Length : 900 bp
Strand : +
Note : transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis

DNA sequence :
ATGATAAATTCTATCAGAATAGGTACAAGAAATAGTACACTTGCTTTAATACAAACTAATTTAGTTATTGAGCAAATCAA
ACAAATTTTTCCTGATATTAATTGTGAAATAGTACCTATTATTACTAGCGGTGACTTAATTCAAAATAAACCATTATACG
ATATAGGTGGTAAGGCTTTGTTCTTAAAGGAAATAGAGCAAGCATTGCTTGACAAAAAAATTGACTTAGCTGTTCATTCT
TTGAAAGATATACCTGGTAAAATACCTGTAGAGCTAGTAATAGCTGCAGTTTTAGAGCGTGAAGATCCAAGAGATGTTTT
GGTATGTTTAAATTATCAATCTATAGAAACACTTCCGCAAAATGCCGTAATAGGTAGCTCGGCAGTGCGAAGAAAAGCAT
TTATAAAAAAAATAAGACCTGATTTAAATATAAAAGTTTTTAGAGGTAATGTTGATTCCAGAATAAAAAAGCTAATGACA
GGTGAAGTTGATGCAATAATTTTATCATATGCAGGACTGAAAAGACTTAATGTGTTTAATCAGAAATATTGTCATCTTAT
AGAGTATTCGAAGATGTTACCGTGTATAGGGCAGGGTGTAATTGCAGTCGAGATCAGAAAAGACGATAATGCTATGTTTA
ATATATGTAGTCAAATTAATCATCTTCCAACCTTTGAATTAATAAAACCTGAAAGAGCATTTTTAGAATATCTAGATGCT
AATTGCAGTACACCGATTGCTGCTTACGCACAATACCTAGATGCGTATAATATACAAATAGATTTTATGCTTGGGAACCT
TGATTGTACTAAAATAATATTCCAAACTGAAATTACCAATATCAAAACTTCAAAAATATGTGGCATCAAAGCTGCTAAAA
TGATGTTGGCACAACAATAA

Protein sequence :
MINSIRIGTRNSTLALIQTNLVIEQIKQIFPDINCEIVPIITSGDLIQNKPLYDIGGKALFLKEIEQALLDKKIDLAVHS
LKDIPGKIPVELVIAAVLEREDPRDVLVCLNYQSIETLPQNAVIGSSAVRRKAFIKKIRPDLNIKVFRGNVDSRIKKLMT
GEVDAIILSYAGLKRLNVFNQKYCHLIEYSKMLPCIGQGVIAVEIRKDDNAMFNICSQINHLPTFELIKPERAFLEYLDA
NCSTPIAAYAQYLDAYNIQIDFMLGNLDCTKIIFQTEITNIKTSKICGIKAAKMMLAQQ

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
BJAB07104_00327 YP_008207792.1 Porphobilinogen deaminase Not tested AbaR25 Protein 4e-47 43
BJAB0868_00331 YP_008211657.1 Porphobilinogen deaminase Not tested AbaR26 Protein 4e-47 43