Gene Information

Name : prrA (Rv0903c)
Accession : NP_215418.1
Strain : Mycobacterium tuberculosis H37Rv
Genome accession: NC_000962
Putative virulence/resistance : Virulence
Product : Two component response transcriptional regulatory protein PrrA
Function : -
COG functional category : T : Signal transduction mechanisms
COG ID : COG0745
EC number : -
Position : 1005852 - 1006562 bp
Length : 711 bp
Strand : -
Note : Rv0903c, (MTCY31.31c), len: 236 aa. PrrA,two-component response regulator (see citations below),equivalent to Z99494|MLCB57_27|NP_302402.1|NC_002677 two-component response regulator from Mycobacterium leprae (233 aa), FASTA scores: opt: 1414, E(): 0, (95.

DNA sequence :
ATGGGCGGCATGGACACTGGTGTGACCTCACCTCGGGTGTTGGTCGTCGACGACGACTCCGATGTGCTCGCCTCGCTGGA
ACGCGGCTTACGGCTGTCCGGATTCGAGGTAGCGACCGCGGTGGACGGCGCCGAGGCCTTGCGCAGCGCCACCGAGAACC
GGCCGGACGCGATCGTGCTCGACATCAACATGCCAGTGCTCGATGGAGTCAGCGTCGTGACGGCACTACGCGCGATGGAC
AACGACGTCCCGGTCTGTGTGCTATCCGCACGCAGCTCTGTCGATGACCGAGTGGCCGGATTGGAGGCCGGCGCCGACGA
TTACCTGGTGAAACCGTTCGTGCTGGCCGAGCTGGTGGCACGGGTGAAGGCGCTGCTGCGCCGCCGCGGCTCCACTGCAA
CGTCGTCCTCGGAAACCATCACGGTGGGCCCGCTGGAGGTGGACATCCCCGGCCGGCGGGCCCGGGTCAACGGCGTCGAC
GTCGACCTGACCAAGCGCGAATTCGACCTGCTCGCGGTGCTGGCCGAGCACAAGACCGCGGTGCTCTCCCGAGCGCAACT
CCTGGAATTGGTGTGGGGCTACGACTTCGCCGCCGACACCAACGTGGTGGACGTCTTCATCGGGTACCTGCGGCGCAAAC
TGGAGGCCGGCGGTGGCCCTAGGCTGCTGCATACCGTCCGCGGAGTCGGATTCGTGCTGCGTATGCAGTGA

Protein sequence :
MGGMDTGVTSPRVLVVDDDSDVLASLERGLRLSGFEVATAVDGAEALRSATENRPDAIVLDINMPVLDGVSVVTALRAMD
NDVPVCVLSARSSVDDRVAGLEAGADDYLVKPFVLAELVARVKALLRRRGSTATSSSETITVGPLEVDIPGRRARVNGVD
VDLTKREFDLLAVLAEHKTAVLSRAQLLELVWGYDFAADTNVVDVFIGYLRRKLEAGGGPRLLHTVRGVGFVLRMQ

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
copR NP_460069.2 transcriptional regulatory protein YedW Not tested SPI-5 Protein 2e-25 42
copR AAC33719.1 regulatory protein CopR Not tested SPI-5 Protein 5e-25 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
prrA NP_215418.1 Two component response transcriptional regulatory protein PrrA BAC0083 Protein 5e-31 46
prrA NP_215418.1 Two component response transcriptional regulatory protein PrrA BAC0125 Protein 7e-30 43
prrA NP_215418.1 Two component response transcriptional regulatory protein PrrA HE999704.1.gene1528. Protein 2e-31 43
prrA NP_215418.1 Two component response transcriptional regulatory protein PrrA BAC0197 Protein 6e-25 43
prrA NP_215418.1 Two component response transcriptional regulatory protein PrrA BAC0638 Protein 4e-24 43
prrA NP_215418.1 Two component response transcriptional regulatory protein PrrA NC_012469.1.7685629. Protein 4e-28 43
prrA NP_215418.1 Two component response transcriptional regulatory protein PrrA AE000516.2.gene3505. Protein 6e-29 43
prrA NP_215418.1 Two component response transcriptional regulatory protein PrrA BAC0308 Protein 1e-27 42
prrA NP_215418.1 Two component response transcriptional regulatory protein PrrA NC_002952.2859905.p0 Protein 2e-27 42
prrA NP_215418.1 Two component response transcriptional regulatory protein PrrA NC_002745.1124361.p0 Protein 3e-27 42
prrA NP_215418.1 Two component response transcriptional regulatory protein PrrA NC_007622.3794472.p0 Protein 2e-27 42
prrA NP_215418.1 Two component response transcriptional regulatory protein PrrA NC_009782.5559369.p0 Protein 3e-27 42
prrA NP_215418.1 Two component response transcriptional regulatory protein PrrA NC_002951.3237708.p0 Protein 3e-27 42
prrA NP_215418.1 Two component response transcriptional regulatory protein PrrA NC_003923.1003749.p0 Protein 3e-27 42
prrA NP_215418.1 Two component response transcriptional regulatory protein PrrA NC_002758.1121668.p0 Protein 3e-27 42
prrA NP_215418.1 Two component response transcriptional regulatory protein PrrA NC_009641.5332272.p0 Protein 3e-27 42
prrA NP_215418.1 Two component response transcriptional regulatory protein PrrA NC_013450.8614421.p0 Protein 3e-27 42
prrA NP_215418.1 Two component response transcriptional regulatory protein PrrA NC_007793.3914279.p0 Protein 3e-27 42
prrA NP_215418.1 Two component response transcriptional regulatory protein PrrA HE999704.1.gene2815. Protein 3e-27 42
prrA NP_215418.1 Two component response transcriptional regulatory protein PrrA BAC0347 Protein 8e-24 41
prrA NP_215418.1 Two component response transcriptional regulatory protein PrrA BAC0111 Protein 5e-26 41
prrA NP_215418.1 Two component response transcriptional regulatory protein PrrA NC_012469.1.7686381. Protein 2e-23 41
prrA NP_215418.1 Two component response transcriptional regulatory protein PrrA NC_002516.2.879194.p Protein 1e-21 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
prrA NP_215418.1 Two component response transcriptional regulatory protein PrrA VFG1389 Protein 1e-87 100
prrA NP_215418.1 Two component response transcriptional regulatory protein PrrA VFG1390 Protein 2e-41 50
prrA NP_215418.1 Two component response transcriptional regulatory protein PrrA VFG1386 Protein 1e-36 46
prrA NP_215418.1 Two component response transcriptional regulatory protein PrrA VFG0596 Protein 7e-26 42