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Name : clpB (Rv0384c) Accession : NP_214898.1 Strain : Mycobacterium tuberculosis H37Rv Genome accession: NC_000962 Putative virulence/resistance : Virulence Product : Probable endopeptidase ATP binding protein (chain B) ClpB (ClpB protein) (heat shock protein F84.1) Function : - COG functional category : O : Posttranslational modification, protein turnover, chaperones COG ID : COG0542 EC number : - Position : 459456 - 462002 bp Length : 2547 bp Strand : - Note : Rv0384c, (MTV036.19c), len: 848 aa. Probable clpB (alternate gene name: htpM), endopeptidase ATP-binding protein, chain B, equivalent to AC32007.1|AL583925 heat shock protein from Mycobacterium leprae (848 aa). Also highly similar to others e.g. P53532|CL DNA sequence : GTGGACTCGTTTAACCCGACGACCAAGACGCAGGCGGCGCTAACCGCGGCGTTACAGGCGGCTTCGACCGCCGGCAATCC CGAGATCCGGCCCGCTCACCTGCTGATGGCGCTGCTGACCCAAAACGACGGTATCGCCGCACCGCTACTGGAGGCTGTCG GTGTCGAGCCCGCCACCGTCCGCGCCGAAACCCAGCGCCTGCTCGACCGTTTGCCGCAGGCGACTGGAGCCAGCACGCAG CCGCAGCTGTCCCGCGAGTCGTTAGCGGCGATCACCACCGCGCAGCAGCTGGCCACCGAGCTGGACGACGAGTACGTCTC CACCGAGCACGTGATGGTCGGGCTGGCCACCGGTGACTCCGACGTCGCCAAGCTGTTGACCGGCCACGGCGCCTCGCCGC AGGCGCTGCGGGAGGCGTTCGTCAAGGTGCGCGGCAGCGCCCGGGTCACCAGCCCCGAACCGGAGGCGACCTATCAGGCG CTGCAGAAGTACTCCACCGACCTGACCGCCCGCGCCCGCGAAGGCAAACTCGACCCGGTCATCGGCCGCGACAACGAGAT CCGCCGCGTGGTGCAGGTGCTGTCCCGTCGCACCAAGAACAACCCGGTGCTGATCGGTGAGCCCGGCGTCGGCAAGACCG CGATCGTGGAGGGCCTGGCGCAGCGCATCGTGGCCGGCGACGTGCCGGAGAGCTTGCGCGACAAGACCATCGTCGCGCTC GATCTCGGCTCGATGGTCGCCGGCTCCAAATACCGCGGCGAATTCGAGGAACGGCTCAAGGCCGTCCTCGACGACATCAA GAACTCGGCCGGCCAAATCATCACGTTCATCGACGAGCTGCACACCATCGTCGGCGCCGGCGCCACCGGCGAGGGGGCGA TGGACGCCGGCAACATGATCAAGCCGATGCTGGCCCGCGGCGAGTTACGGCTGGTCGGGGCGACCACGCTGGACGAATAC CGCAAGCACATCGAGAAGGACGCCGCGCTCGAGCGCCGTTTCCAACAGGTGTACGTCGGCGAGCCGTCGGTGGAGGACAC CATCGGCATCCTGCGCGGGCTCAAAGACCGCTACGAGGTGCACCACGGGGTGCGCATCACCGACTCGGCGCTGGTGGCAG CTGCCACTTTGAGCGACCGGTATATCACCGCCCGCTTCCTGCCCGACAAGGCCATCGACCTGGTCGACGAGGCGGCCAGC CGGCTGCGGATGGAGATCGACTCGCGGCCCGTCGAGATCGACGAGGTCGAGCGGCTGGTGCGCCGGCTGGAGATCGAAGA GATGGCGCTGTCCAAAGAAGAAGACGAGGCGTCGGCGGAGCGGTTGGCCAAGCTGCGCTCCGAGCTGGCCGACCAGAAAG AGAAGTTGGCCGAGCTCACCACCCGCTGGCAGAACGAGAAGAACGCGATCGAAATCGTCCGCGACCTCAAGGAGCAGCTG GAAGCCCTGCGCGGGGAATCCGAGCGGGCCGAACGCGACGGCGACCTGGCCAAGGCCGCCGAGCTGCGCTACGGACGCAT CCCCGAGGTGGAGAAGAAGCTCGACGCGGCGTTGCCGCAGGCGCAGGCCCGGGAGCAGGTGATGCTCAAGGAGGAGGTCG GTCCCGACGACATCGCCGACGTGGTGTCGGCGTGGACCGGCATCCCGGCCGGTCGGCTGCTGGAAGGCGAGACCGCCAAG CTGCTGCGCATGGAAGACGAGCTGGGCAAGCGGGTCATCGGGCAGAAGGCCGCGGTTACCGCAGTCTCTGATGCGGTGCG GCGCAGCCGGGCCGGGGTGTCCGACCCCAACCGGCCCACCGGGGCGTTCATGTTCCTCGGCCCGACCGGTGTCGGCAAGA CCGAGCTGGCCAAGGCGCTGGCCGACTTCCTGTTCGACGACGAGCGGGCGATGGTCCGCATCGACATGAGCGAGTACGGC GAGAAGCACACCGTGGCTCGGTTGATCGGCGCCCCGCCCGGCTATGTGGGATACGAGGCGGGCGGTCAGCTGACCGAGGC GGTGCGCCGGCGTCCCTACACGGTGGTGCTGTTCGACGAGATCGAGAAGGCGCACCCGGACGTGTTCGACGTGCTGCTGC AGGTCCTCGACGAGGGCCGGCTCACCGACGGGCACGGCCGCACGGTCGACTTCCGCAACACCATCTTGATCCTGACGTCC AACCTGGGGTCGGGTGGCAGCGCCGAGCAGGTGCTGGCCGCGGTGCGCGCTACGTTCAAGCCGGAGTTCATCAACCGGCT CGACGACGTGCTCATCTTTGAGGGTCTCAACCCCGAAGAGCTGGTGCGCATCGTCGACATCCAGCTGGCGCAGCTGGGCA AGCGGCTGGCGCAGCGGCGGCTGCAGCTGCAGGTCTCGCTGCCGGCCAAGCGCTGGTTGGCGCAGCGCGGATTCGACCCG GTGTACGGGGCGCGGCCGTTGCGCCGGCTGGTGCAGCAGGCCATCGGTGACCAGCTGGCCAAGATGCTGTTGGCCGGCCA GGTGCACGACGGCGATACCGTGCCGGTCAACGTCAGCCCCGACGCCGACTCGCTGATCCTGGGCTGA Protein sequence : MDSFNPTTKTQAALTAALQAASTAGNPEIRPAHLLMALLTQNDGIAAPLLEAVGVEPATVRAETQRLLDRLPQATGASTQ PQLSRESLAAITTAQQLATELDDEYVSTEHVMVGLATGDSDVAKLLTGHGASPQALREAFVKVRGSARVTSPEPEATYQA LQKYSTDLTARAREGKLDPVIGRDNEIRRVVQVLSRRTKNNPVLIGEPGVGKTAIVEGLAQRIVAGDVPESLRDKTIVAL DLGSMVAGSKYRGEFEERLKAVLDDIKNSAGQIITFIDELHTIVGAGATGEGAMDAGNMIKPMLARGELRLVGATTLDEY RKHIEKDAALERRFQQVYVGEPSVEDTIGILRGLKDRYEVHHGVRITDSALVAAATLSDRYITARFLPDKAIDLVDEAAS RLRMEIDSRPVEIDEVERLVRRLEIEEMALSKEEDEASAERLAKLRSELADQKEKLAELTTRWQNEKNAIEIVRDLKEQL EALRGESERAERDGDLAKAAELRYGRIPEVEKKLDAALPQAQAREQVMLKEEVGPDDIADVVSAWTGIPAGRLLEGETAK LLRMEDELGKRVIGQKAAVTAVSDAVRRSRAGVSDPNRPTGAFMFLGPTGVGKTELAKALADFLFDDERAMVRIDMSEYG EKHTVARLIGAPPGYVGYEAGGQLTEAVRRRPYTVVLFDEIEKAHPDVFDVLLQVLDEGRLTDGHGRTVDFRNTILILTS NLGSGGSAEQVLAAVRATFKPEFINRLDDVLIFEGLNPEELVRIVDIQLAQLGKRLAQRRLQLQVSLPAKRWLAQRGFDP VYGARPLRRLVQQAIGDQLAKMLLAGQVHDGDTVPVNVSPDADSLILG |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| STY0294 | NP_454876.1 | ClpB-like protein | Not tested | SPI-6 | Protein | 1e-104 | 43 |
| aec27 | YP_851418.1 | ATPase | Not tested | PAI II APEC-O1 | Protein | 2e-105 | 42 |
| aec27 | AAQ96721.1 | Aec27 | Not tested | AGI-1 | Protein | 2e-105 | 42 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| clpB | NP_214898.1 | Probable endopeptidase ATP binding protein (chain B) ClpB (ClpB protein) (heat shock protein F84.1) | VFG2076 | Protein | 4e-112 | 44 |
| clpB | NP_214898.1 | Probable endopeptidase ATP binding protein (chain B) ClpB (ClpB protein) (heat shock protein F84.1) | VFG2084 | Protein | 1e-111 | 41 |
