Gene Information

Name : dfrA (Rv2763c)
Accession : NP_217279.1
Strain : Mycobacterium tuberculosis H37Rv
Genome accession: NC_000962
Putative virulence/resistance : Resistance
Product : Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)
Function : -
COG functional category : H : Coenzyme transport and metabolism
COG ID : COG0262
EC number : -
Position : 3073130 - 3073609 bp
Length : 480 bp
Strand : -
Note : Rv2763c, (MTV002.28c), len: 159 aa. Probable dfrA (alternate gene names: folA, dhfr), dihydrofolate reductase, equivalent to O30463|FOLA dihydrofolate reductase from Mycobacterium avium (see citation below) (181 aa), FASTA scores: opt: 802, E(): 4.5e-48,

DNA sequence :

ATGGTGGGGCTGATCTGGGCTCAAGCGACATCGGGTGTCATCGGCCGCGGCGGCGACATCCCCTGGCGCTTGCCCGAGGA
CCAGGCGCATTTCCGGGAGATCACCATGGGGCACACGATCGTGATGGGCCGGCGCACATGGGATTCGCTGCCGGCTAAAG
TCCGGCCGCTGCCCGGCCGGCGAAATGTCGTACTGAGCCGCCAAGCTGACTTTATGGCCAGCGGGGCTGAGGTTGTCGGT
TCACTCGAGGAGGCGCTGACCAGCCCGGAGACGTGGGTGATCGGAGGCGGACAAGTCTATGCGCTGGCGCTGCCGTACGC
GACCAGATGTGAGGTTACCGAGGTCGACATCGGCCTGCCGCGCGAAGCCGGTGACGCGCTGGCCCCCGTGCTGGACGAGA
CATGGCGGGGCGAGACGGGGGAGTGGCGCTTCAGCCGGTCCGGGTTGCGGTACCGGTTGTACAGCTACCACCGCTCATGA

Protein sequence :

MVGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNVVLSRQADFMASGAEVVG
SLEEALTSPETWVIGGGQVYALALPYATRCEVTEVDIGLPREAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHRS

• Homologs from PAI DB

Gene	GenBank Accn	Product	Virulance or Resistance	PAI or REI	Alignment Type	E-val	Identity
dfrA12	ACF06156.1	dihydrofolate reductase	Not tested	Tn5036-like	Protein	5e-19	41