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Name : mbtA (Rv2384) Accession : NP_216900.1 Strain : Mycobacterium tuberculosis H37Rv Genome accession: NC_000962 Putative virulence/resistance : Virulence Product : Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Function : - COG functional category : Q : Secondary metabolites biosynthesis, transport and catabolism COG ID : COG1021 EC number : - Position : 2675936 - 2677633 bp Length : 1698 bp Strand : + Note : Rv2384, (MTCY22H8.01, MTCY253.37c), len: 565 aa. mbtA, bifunctional enzyme, including salicyl-AMP ligase (Sal-AMP ligase) and salicyl-S-ArCP synthetase (see Quadri et al., 1998; De Voss et al., 1999), highly similar to other ligases e.g. Q9F638|MXCE from DNA sequence : ATGCCACCGAAGGCGGCAGATGGCCGCCGACCCAGTCCCGACGGCGGACTGGGTGGCTTTGTACCGTTCCCCGCGGATCG GGCCGCGTCGTACCGGGCGGCCGGCTATTGGTCGGGGCGAACCCTGGACACCGTGCTCTCCGATGCCGCGCGGCGCTGGC CTGACCGCCTCGCGGTGGCCGACGCCGGTGATCGTCCCGGCCACGGCGGCCTCAGTTACGCCGAACTCGACCAGCGGGCC GACCGGGCCGCCGCGGCGCTGCACGGCCTGGGCATCACGCCAGGCGACCGGGTACTGCTCCAGCTGCCAAACGGCTGCCA GTTCGCGGTTGCCCTGTTCGCGTTATTGCGGGCGGGAGCGATCCCAGTGATGTGCCTGCCCGGTCACCGCGCCGCCGAAT TGGGCCACTTCGCCGCCGTCAGCGCGGCCACCGGGCTGGTGGTCGCCGATGTGGCCAGCGGGTTCGACTATCGGCCGATG GCGCGCGAACTTGTTGCCGATCACCCCACCCTGCGCCATGTCATCGTCGATGGCGATCCGGGACCGTTCGTGTCGTGGGC GCAGCTGTGCGCCCAGGCCGGCACCGGTTCGCCGGCACCGCCGGCCGATCCCGGATCGCCAGCGCTGCTGCTGGTCTCCG GCGGCACCACTGGCATGCCCAAACTCATTCCACGCACCCACGACGACTACGTGTTCAACGCGACGGCCAGCGCCGCACTC TGTCGGCTTAGCGCCGACGACGTCTATCTGGTGGTGCTGGCCGCCGGCCACAATTTCCCGCTGGCCTGCCCGGGCCTGCT CGGCGCGATGACCGTCGGGGCCACCGCCGTGTTCGCCCCCGATCCCAGCCCGGAGGCCGCCTTCGCCGCCATCGAGCGCC ACGGTGTCACCGTCACCGCGTTGGTTCCGGCACTGGCCAAACTGTGGGCCCAATCCTGTGAGTGGGAGCCGGTGACACCG AAGTCACTGCGGTTGTTGCAGGTTGGCGGGTCCAAGCTAGAACCCGAGGACGCTCGCCGGGTACGCACCGCGCTCACCCC GGGCCTGCAGCAGGTGTTCGGCATGGCGGAGGGGCTGCTGAACTTCACCCGCATCGGCGACCCACCCGAAGTGGTGGAGC ACACCCAGGGGCGGCCACTATGCCCGGCCGACGAACTGCGCATCGTCAACGCCGATGGTGAGCCGGTGGGGCCCGGGGAG GAAGGCGAACTCTTGGTGCGCGGGCCCTACACGCTGAACGGCTATTTTGCTGCCGAACGCGACAACGAGCGCTGCTTCGA TCCGGACGGCTTCTACCGCAGCGGCGACCTGGTCCGCCGCCGCGACGACGGCAATCTGGTGGTCACCGGGCGCGTCAAGG ATGTCATCTGCCGTGCGGGAGAAACCATCGCCGCCAGCGACCTCGAAGAACAGCTGCTGAGCCATCCGGCGATCTTCTCG GCCGCGGCGGTGGGACTACCTGACCAGTATCTGGGGGAAAAAATCTGCGCTGCAGTCGTTTTCGCTGGAGCTCCGATTAC GCTTGCGGAGTTGAACGGCTACCTTGACCGGCGTGGTGTGGCCGCGCATACGCGACCCGACCAGCTGGTCGCGATGCCGG CGCTGCCCACAACGCCGATCGGGAAGATCGACAAACGAGCGATCGTCCGCCAGCTCGGCATCGCGACGGGTCCCGTGACG ACCCAGCGCTGCCATTGA Protein sequence : MPPKAADGRRPSPDGGLGGFVPFPADRAASYRAAGYWSGRTLDTVLSDAARRWPDRLAVADAGDRPGHGGLSYAELDQRA DRAAAALHGLGITPGDRVLLQLPNGCQFAVALFALLRAGAIPVMCLPGHRAAELGHFAAVSAATGLVVADVASGFDYRPM ARELVADHPTLRHVIVDGDPGPFVSWAQLCAQAGTGSPAPPADPGSPALLLVSGGTTGMPKLIPRTHDDYVFNATASAAL CRLSADDVYLVVLAAGHNFPLACPGLLGAMTVGATAVFAPDPSPEAAFAAIERHGVTVTALVPALAKLWAQSCEWEPVTP KSLRLLQVGGSKLEPEDARRVRTALTPGLQQVFGMAEGLLNFTRIGDPPEVVEHTQGRPLCPADELRIVNADGEPVGPGE EGELLVRGPYTLNGYFAAERDNERCFDPDGFYRSGDLVRRRDDGNLVVTGRVKDVICRAGETIAASDLEEQLLSHPAIFS AAAVGLPDQYLGEKICAAVVFAGAPITLAELNGYLDRRGVAAHTRPDQLVAMPALPTTPIGKIDKRAIVRQLGIATGPVT TQRCH |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| irp5 | YP_001006819.1 | yersiniabactin siderophore biosynthetic protein | Virulence | HPI | Protein | 8e-86 | 45 |
| irp5 | CAA73130.1 | Irp5 protein | Virulence | HPI | Protein | 6e-86 | 45 |
| ybtE | NP_669710.1 | salicyl-AMP ligase | Virulence | HPI | Protein | 4e-85 | 44 |
| ybtE | NP_993003.1 | yersiniabactin siderophore biosynthetic protein | Virulence | HPI | Protein | 4e-85 | 44 |
| ybtE | YP_070120.1 | yersiniabactin siderophore biosynthetic protein | Virulence | HPI | Protein | 4e-85 | 44 |
| ybtE | CAA21394.1 | - | Virulence | HPI | Protein | 4e-85 | 44 |
| ybtE | AAA93464.1 | yersiniabactin 2,3-dihydoxybenzoate-AMP ligase | Virulence | HPI | Protein | 3e-85 | 44 |
| ybtE | YP_853079.1 | yersiniabactin siderophore biosynthetic protein | Virulence | PAI IV APEC-O1 | Protein | 5e-85 | 44 |
| irp5 | YP_002346898.1 | yersiniabactin siderophore biosynthetic protein | Virulence | HPI | Protein | 4e-85 | 44 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| mbtA | NP_216900.1 | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | VFG1817 | Protein | 0.0 | 100 |
| mbtA | NP_216900.1 | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | VFG0168 | Protein | 2e-85 | 46 |
