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Name : ureC (Rv1850) Accession : NP_216366.1 Strain : Mycobacterium tuberculosis H37Rv Genome accession: NC_000962 Putative virulence/resistance : Virulence Product : Urease alpha subunit UreC (urea amidohydrolase) Function : - COG functional category : E : Amino acid transport and metabolism COG ID : COG0804 EC number : - Position : 2097961 - 2099694 bp Length : 1734 bp Strand : + Note : Rv1850, (MTCY359.23c), len: 577 aa. UreC, urease alpha subunit. Similar to URE1_MYCTU|P50042 from Mycobacterium tuberculosis (577 aa), FASTA scores: opt: 3794, E(): 0, (98.3% identity in 577 aa overlap). Contains PS00145 Urease active site motif. Belongs DNA sequence : ATGGCGCGACTGTCAAGGGAGCGCTACGCACAGCTGTACGGACCTACCACCGGCGACCGGATACGGCTGGCCGACACCAA CCTGCTGGTTGAGGTCACCGAAGACCGGTGTGGGGGACCGGGACTGGCCGGTGACGAGGCGGTGTTCGGCGGCGGCAAGG TGCTGCGCGAGTCCATGGGCCAGGGCCGTGCGAGCCGGGCCGACGGTGCCCCCGACACCGTGATCACCGGTGCGGTGATC ATCGACTACTGGGGAATCATCAAGGCCGACATCGGGATTCGCGATGGCCGCATCGTCGGGATCGGAAAGGCCGGCAATCC CGACATCATGACAGGTGTGCATCGGGATCTCGTCGTCGGGCCGTCCACCGAAATCATCAGCGGCAACCGTCGAATCGTCA CCGCAGGCACCGTCGACTGTCACGTGCACTTGATCTGTCCGCAGATCATCGTCGAAGCCTTGGCCGCGGGCACCACCACG ATCATCGGCGGTGGCACCGGACCCGCCGAGGGCACCAAGGCCACCACAGTCACTCCCGGCGAGTGGCACCTGGCCCGGAT GCTGGAGTCACTGGACGGTTGGCCGGTGAACTTCGCGCTGCTCGGCAAGGGAAACACCGTGAATCCCGACGCACTGTGGG AACAGTTGCGCGGTGGCGCATCGGGTTTCAAACTCCACGAAGACTGGGGATCGACCCCGGCGGCCATCGACACCTGCTTG GCGGTCGCCGACGTGGCCGGGGTGCAGGTTGCGCTGCACTCCGACACTCTCAATGAGACCGGATTCGTCGAGGACACCAT CGGCGCGATCGCCGGACGTTCGATTCACGCCTACCACACCGAGGGCGCCGGCGGCGGGCACGCACCGGACATCATTACCG TCGCGGCGCAACCGAATGTACTGCCCAGCTCGACCAATCCGACCCGCCCGCATACGGTGAACACCCTTGACGAGCATCTC GACATGCTGATGGTGTGCCACCACCTCAACCCCCGGATCCCGGAGGACCTCGCGTTTGCCGAAAGCCGGATCCGACCGTC CACCATTGCGGCAGAAGATGTGTTGCACGATATGGGGGCAATCTCGATGATTGGCAGCGATTCCCAGGCGATGGGCCGTG TCGGCGAGGTGGTGCTGCGCACCTGGCAGACCGCGCACGTGATGAAAGCCCGCCGCGGGGCACTGGAAGGTGACCCGTCT GGTAGCCAAGCCGCCGACAACAACCGGGTCCGCCGCTACATCGCCAAATACACCATCTGCCCGGCCATCGCACACGGCAT GGATCACCTGATCGGTTCGGTGGAGGTGGGAAAGTTGGCCGACCTGGTGTTGTGGGAGCCGGCGTTTTTCGGGGTTCGCC CGCACGTCGTGCTCAAAGGTGGGGCGATCGCCTGGGCAGCGATGGGCGATGCGAACGCGTCAATCCCGACCCCGCAACCG GTGCTCCCGCGACCGATGTTCGGCGCGGCCGCGGCAACCGCGGCGGCGACCTCGGTGCACTTCGTCGCGCCGCAATCCAT CGACGCGCGCCTGGCGGACCGGCTCGCGGTCAATCGGGGACTAGCGCCGGTGGCCGACGTGCGCGCAGTGGGCAAGACCG ACCTGCCGCTCAATGATGCCCTACCGAGCATCGAGGTCGATCCCGACACCTTCACCGTGCGAATCGACGGCCAGGTGTGG CAACCGCAGCCGGCCGCCGAACTACCTATGACACAACGGTATTTCCTGTTCTAA Protein sequence : MARLSRERYAQLYGPTTGDRIRLADTNLLVEVTEDRCGGPGLAGDEAVFGGGKVLRESMGQGRASRADGAPDTVITGAVI IDYWGIIKADIGIRDGRIVGIGKAGNPDIMTGVHRDLVVGPSTEIISGNRRIVTAGTVDCHVHLICPQIIVEALAAGTTT IIGGGTGPAEGTKATTVTPGEWHLARMLESLDGWPVNFALLGKGNTVNPDALWEQLRGGASGFKLHEDWGSTPAAIDTCL AVADVAGVQVALHSDTLNETGFVEDTIGAIAGRSIHAYHTEGAGGGHAPDIITVAAQPNVLPSSTNPTRPHTVNTLDEHL DMLMVCHHLNPRIPEDLAFAESRIRPSTIAAEDVLHDMGAISMIGSDSQAMGRVGEVVLRTWQTAHVMKARRGALEGDPS GSQAADNNRVRRYIAKYTICPAIAHGMDHLIGSVEVGKLADLVLWEPAFFGVRPHVVLKGGAIAWAAMGDANASIPTPQP VLPRPMFGAAAATAAATSVHFVAPQSIDARLADRLAVNRGLAPVADVRAVGKTDLPLNDALPSIEVDPDTFTVRIDGQVW QPQPAAELPMTQRYFLF |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| ureC | NP_287088.1 | urease subunit alpha | Not tested | TAI | Protein | 9e-147 | 62 |
| ureC | NP_286680.1 | urease subunit alpha | Virulence | TAI | Protein | 9e-147 | 62 |
| ureC | YP_005684266.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 6e-147 | 58 |
| ureC | YP_005682174.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 6e-147 | 58 |
| ureC | YP_003784325.1 | urease subunit alpha | Not tested | PiCp 7 | Protein | 6e-147 | 58 |
| ureC | YP_005686358.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 6e-147 | 58 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| ureC | NP_216366.1 | Urease alpha subunit UreC (urea amidohydrolase) | VFG0270 | Protein | 7e-131 | 55 |
