Gene Information

Name : rphA (Rv1340)
Accession : NP_215856.1
Strain : Mycobacterium tuberculosis H37Rv
Genome accession: NC_000962
Putative virulence/resistance : Unknown
Product : Probable ribonuclease RphA (RNase PH) (tRNA nucleotidyltransferase)
Function : -
COG functional category : J : Translation, ribosomal structure and biogenesis
COG ID : COG0689
EC number : -
Position : 1506755 - 1507534 bp
Length : 780 bp
Strand : +
Note : Rv1340, (MTCY130.25), len: 259 aa. Probable rphA,Ribonuclease ph, highly similar to others e.g. RNPH_MYCLE|P37939 Mycobacterium leprae (259 aa), FASTA scores: opt: 1524, E(): 0, (88.8% identity in 259 aa overlap). Belongs to the RNASE PH family.

DNA sequence :
GTGTCCAAGCGAGAAGACGGCCGGCTCGACCACGAGCTTCGCCCGGTGATCATCACCCGCGGTTTCACCGAAAACCCGGC
GGGATCGGTGCTCATCGAATTCGGTCACACCAAGGTCCTGTGCACCGCCAGCGTCACCGAAGGGGTGCCCCGGTGGCGTA
AAGCAACCGGTCTGGGGTGGCTCACCGCGGAGTACGCCATGCTGCCGTCGGCCACCCACAGCCGCTCTGATCGCGAGTCG
GTGAGAGGCAGGCTTAGCGGGCGTACTCAGGAAATCAGTCGGCTCATCGGCCGGTCGCTGCGCGCATGCATCGACCTGGC
GGCGCTGGGGGAGAACACGATCGCTATCGATTGTGATGTGTTGCAGGCCGATGGTGGCACTCGAACCGCGGCCATCACCG
GCGCCTACGTGGCATTGGCCGACGCAGTGACCTACTTGTCGGCGGCGGGTAAGTTGTCCGACCCCAGGCCATTGTCGTGT
GCCATCGCCGCGGTCAGCGTCGGTGTTGTCGACGGCAGGATCCGGGTGGATCTGCCCTACGAGGAAGATTCGCGCGCCGA
GGTCGACATGAACGTCGTCGCTACCGACACCGGAACCCTGGTAGAGATTCAGGGCACCGGCGAAGGCGCGACGTTCGCAC
GTTCGACACTGGATAAGCTGCTGGACATGGCACTGGGCGCCTGCGACACGTTGTTTGCCGCACAACGCGACGCGTTGGCG
CTGCCGTATCCGGGTGTGCTGCCGCAGGGACCGCCACCGCCGAAGGCGTTTGGCACCTGA

Protein sequence :
MSKREDGRLDHELRPVIITRGFTENPAGSVLIEFGHTKVLCTASVTEGVPRWRKATGLGWLTAEYAMLPSATHSRSDRES
VRGRLSGRTQEISRLIGRSLRACIDLAALGENTIAIDCDVLQADGGTRTAAITGAYVALADAVTYLSAAGKLSDPRPLSC
AIAAVSVGVVDGRIRVDLPYEEDSRAEVDMNVVATDTGTLVEIQGTGEGATFARSTLDKLLDMALGACDTLFAAQRDALA
LPYPGVLPQGPPPPKAFGT

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
rph YP_001800860.1 ribonuclease PH Not tested Not named Protein 2e-68 65