Gene Information

Name : PH0710 (PH0710)
Accession : NP_142656.1
Strain : Pyrococcus horikoshii OT3
Genome accession: NC_000961
Putative virulence/resistance : Unknown
Product : seryl-tRNA synthetase
Function : -
COG functional category : J : Translation, ribosomal structure and biogenesis
COG ID : COG0172
EC number : 6.1.1.11
Position : 632203 - 633585 bp
Length : 1383 bp
Strand : -
Note : catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA

DNA sequence :
ATGGAGGGGATAGATATGCTGGATATAAAGCTGATCCGTGAAAACCCCGAATTAGTTAAAAACGACTTGATAAAAAGGGG
AGAGCTAGAGAAAGTTAAGTGGGTAGATGAGATTCTAAAGCTCGACACAGAATGGAGGACTAAGCTTAAGGAGATAAACA
GACTTAGGCATGAGAGAAACAAGATCGCAGTAGAAATTGGAAAGAGAAGAAAAAAAGGAGAACCCGTTGATGAACTTTTA
GCAAAAAGCAGAGAGATCGTCAAAAGAATAGGAGAACTCGAAAATGAAGTTGAGGAACTAAAGAAAAAGATCGATTATTA
CCTATGGAGACTTCCAAACATTACCCATCCAAGCGTCCCAGTTGGGAAGGATGAAAATGATAACGTCCCCATAAGATTCT
GGGGAAAAGCCAGAGTTTGGAAAGGCCACCTTGAAAGATTCCTGGAGCAGAGCCAAGGGAAGATGGAGTATGAAATTCTT
GAATGGAAACCAAAACTGCACGTTGACCTCTTAGAAATCCTAGGAGGAGCAGACTTCGCAAGGGCCGCGAAGGTCAGCGG
TTCCAGGTTCTATTACCTCCTCAACGAGATAGTGATACTTGATCTAGCCCTAATTAGGTTCGCCCTTGACAGGCTCATAG
AGAAGGGCTTTACGCCGGTAATTCCTCCTTATATGGTTAGAAGGTTCGTTGAGGAAGGATCTACTAGCTTTGAGGACTTT
GAGGATGTTATATACAAGGTTGAAGATGAGGATCTATATCTAATTCCGACCGCTGAACACCCCTTAGCTGGAATGCACGC
GAACGAGATATTAGATGGAAAAGATTTACCCCTCCTCTACGTCGGTGTTTCACCATGCTTTAGAAAAGAAGCAGGAACAG
CTGGAAAGGATACTAAGGGAATATTTAGGGTTCACCAATTCCATAAGGTAGAACAGTTCGTCTACTCAAGACCTGAAGAA
AGCTGGGAGTGGCATGAGAAAATAATAAGGAACGCTGAAGAGCTATTCCAGGAGTTAGAGATACCATACAGAGTTGTAAA
CATCTGTACCGGAGATTTAGGTTACGTCGCAGCTAAGAAGTACGACATAGAAGCCTGGATGCCAGGACAAGGTAAATTTA
GGGAAGTAGTCTCAGCAAGCAATTGTACTGATTGGCAGGCTAGGAGGCTTAACATAAGGTTTAGGGATAGGACTGATGAA
AAGCCCAGGTACGTTCACACTCTAAATTCAACGGCAATAGCTACTTCTAGAGCGATAGTTGCAATCCTGGAAAACCATCA
GGAGGAAGATGGAACCGTTAGGATCCCAAAGGTTCTGTGGAAATACACAGGGTTTAAGGAGATAGTTCCAGTAGAAAAGA
AGGAGAGGTGTTGCGCAACTTGA

Protein sequence :
MEGIDMLDIKLIRENPELVKNDLIKRGELEKVKWVDEILKLDTEWRTKLKEINRLRHERNKIAVEIGKRRKKGEPVDELL
AKSREIVKRIGELENEVEELKKKIDYYLWRLPNITHPSVPVGKDENDNVPIRFWGKARVWKGHLERFLEQSQGKMEYEIL
EWKPKLHVDLLEILGGADFARAAKVSGSRFYYLLNEIVILDLALIRFALDRLIEKGFTPVIPPYMVRRFVEEGSTSFEDF
EDVIYKVEDEDLYLIPTAEHPLAGMHANEILDGKDLPLLYVGVSPCFRKEAGTAGKDTKGIFRVHQFHKVEQFVYSRPEE
SWEWHEKIIRNAEELFQELEIPYRVVNICTGDLGYVAAKKYDIEAWMPGQGKFREVVSASNCTDWQARRLNIRFRDRTDE
KPRYVHTLNSTAIATSRAIVAILENHQEEDGTVRIPKVLWKYTGFKEIVPVEKKERCCAT

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
serS YP_003446791.1 seryl-tRNA synthetase Not tested The aminoglycoside resistance gene cluster Protein 1e-71 41