Gene Information

Name : cagA (jhp0495)
Accession : NP_223213.1
Strain : Helicobacter pylori J99
Genome accession: NC_000921
Putative virulence/resistance : Virulence
Product : cag island protein, cytotoxicity associated immunodominant antigen
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 543605 - 547108 bp
Length : 3504 bp
Strand : +
Note : similar to H. pylori 26695 gene HP0547

DNA sequence : 
ATGACTAACGAAGCCATTAACCAACAACCACAAACCGAAGCGGCTTTTAACCCGCAGCAATTTATCAATAATCTTCAAGT
GGCTTTTATTAAAGTTGATAATGTTGTCGCTTCATTTGATCCTAATCAAAAACCAATCGTTGATAAGAATGATAGGGATA
ATAGGCAAGCTTTTGAGAAAATCTCGCAGCTAAGGGAGGAATTCGCTAATAAAGCGATCAAAAATCCTACCAAAAAGAAT
CAGTATTTTTCAAGCTTTATCAGTAAGAGCAATGATTTAATCGACAAAGACAATCTCATTGATACAGGTTCTTCCATAAA
GAGCTTTCAGAAATTTGGGACTCAGCGTTACCAAATTTTTATGAATTGGGTGTCCCATCAAAACGATCCGTCTAAAATCA
ACACCCAAAAAATCCGAGGTTTTATGGAAAATATCATACAACCCCCTATCTCTGATGATAAAGAGAAAGCGGAGTTTTTG
AGGTCTGCCAAACAAGCTTTTGCAGGAATTATCATAGGAAACCAAATCCGATCGGATCAAAAATTCATGGGCGTGTTTGA
TGAATCTTTGAAAGAGAGGCAAGAAGCAGAAAAAAATGGAGAGCCTAATGGAGATCCTACTGGTGGGGATTGGCTTGATA
TTTTTTTATCATTTGTGTTTAACAAAAAACAATCTTCCGATCTCAAAGAAACGCTCAATCAAGAACCAGTTCCTCATGTC
CAACCAGATGTAGCCACTACCACCACTGACATACAAAGCTTACCGCCTGAAGCTAGGGATTTGCTTGATGAAAGGGGTAA
TTTTTCTAAATTCACTCTTGGCGATATGAACATGTTAGATGTTGAGGGAGTCGCTGACATTGATCCTAATTACAAGTTCA
ACCAATTATTGATCCACAATAACGCTCTGTCTTCTGTGTTAATGGGGAGTCATAATGGCATAGAACCTGAAAAAGTTTCA
TTGTTGTATGGAAACAATGGTGGTCCTGAAGCTAGGCATGATTGGAACGCCACCGTTGGTTATAAAAACCAACGAGGCGA
CAATGTGGCTACACTCATTAATGTGCATATGAAAAATGGCAGTGGGTTAGTCATAGCAGGTGGTGAGAAAGGGATTAACA
ACCCTAGTTTTTATCTCTACAAAGAAGACCAACTCACAGGCTCACAACGAGCATTGAGTCAAGAAGAGATCCAAAACAAA
GTGGATTTCATGGAATTTCTTGCACAAAATAATGCTAAATTAGACAACTTGAGCAAGAAAGAGAAAGAAAAATTCCAAAA
TGAGATTGAAGATTTTCAAAAAGACTCTAAGGCTTATTTAGACGCCCTAGGGAATGATCACATTGCTTTTGTTTCTAAAA
AAGACAAAAAACATTTAGCTTTAGTTGCTGAGTTTGGTAATGGGGAATTGAGCTACACTCTCAAAGATTATGGGAAAAAA
GCAGATAAAGCTTTAGATAGGGAGGCAAAAACCACTCTTCAAGGTAGCCTAAAACATGATGGCGTGATGTTTGTTGATTA
TTCTAATTTCAAATACACCAACGCCTCCAAGAGTCCTGATAAGGGTGTGGGTGCTACGAATGGCGTTTCCCATTTAGAAG
CAGGCTTTAGCAAGGTAGCTGTCTTTAATTTGCCTAATTTAAATAATCTCGCTATCACTAGTGTCGTAAGGCAGGATTTA
GAGGATAAACTAATCGCTAAAGGATTGTCCCCACAAGAAGCTAATAAGCTTGTCAAAGATTTTTTGAGCAGCAACAAAGA
ATTGGTTGGAAAAGCTTTAAACTTCAATAAAGCTGTAGCTGAAGCTAAAAACACAGGCAACTATGACGAGGTGAAACAAG
CTCAGAAAGATCTTGAAAAATCTCTAAAGAAACGAGAGCGTTTGGAGAAAGATGTAGCGAAAAATTTGGAGAGCAAAAGC
GGCAACAAAAATAAAATGGAAGCAAAATCTCAAGCTAACAGCCAAAAAGATGAGATTTTTGCGTTGATCAATAAAGAGGC
TAATAGGGATGCAAGAGCAATCGCTTACGCTCAGAATCTTAAAGGCATCAAAAGGGAATTGTCTGATAAACTTGAAAATA
TCAACAAGGATTTGAAAGACTTTAGTAAATCTTTTGATGAATTCAAAAATGGCAAAAATAAGGATTTCAGCAAGGCAGAA
GAAACACTAAAAGCCCTTAAAGGCTCGGTGAAAGATTTAGGTATCAATCCAGAATGGATTTCAAAAGTTGAAAACCTTAA
TGCAGCTTTGAATGAATTCAAAAATGGCAAAAATAAGGATTTCAGCAAGGTAACGCAAGCAAAAAGCGACCTTGAAAATT
CCATTAAAGATGTGATCATCAATCAAAAGATAACGGATAAAGTTGATAATCTCAATCAAGCGGTATCAGTGGCTAAAGCA
ACGGGTGATTTCAGTGGGGTAGAGCAAGCGTTAGCCGATCTCAAAAATTTCTCAAAGGAGCAATTGGCTCAACAAGCTCA
AAAAAATGAAGATTTCAATACTGGAAAAAATTCTGCACTATACCAATCCGTTAAGAATGGTGTAAACGGAACCCTAGTCG
GTAATGGGTTATCTAAAGCAGAAGCCACAACTCTTTCTAAAAACTTTTCGGACATCAAGAAAGAGTTGAATGCAAAACTT
GGAAATTTCAATAACAATAACAATAATGGACTCGAAAACAGCACAGAACCCATTTATACTCAAGTTGCTAAAAAGGTAAA
AGCAAAAATTGACCGACTCGATCAAATAGCAAGTGGTTTGGGTGATGTAGGGCAAGCAGCGAGCTTCCTTTTGAAAAGGC
ATGATAAAGTTGATGATCTCAGTAAGGTAGGGCTTTCAGCTAACCATGAACCCATTTACGCTACGATTGATGATCTCGGC
GGACCTTTCCCTTTGAAAAGGCATGATAAAGTTGATGATCTCAGTAAGGTAGGGCTTTCAAGGGAGCAAAAATTGACTCA
GAAAATTGACAATCTCAACCAGGCGGTATCAGAAGCTAAAGCAAGTCATTTTGACAACCTAGATCAAATGATAGACAAGC
TCAAAGATTCTACAAAAAAGAATGTTGTGAATCTATATGTTGAAAGTGCAAAAAAAGTGCCTACTAGTTTGTCAGCGAAA
TTGGACAATTACGCTACTAACAGCCACACACGCATTAATAGCAATGTCAAAAATGGAACAATCAATGAAAAAGCGACCGG
CATGCTAACGCAAAAAAATTCTGAGTGGCTCAAGCTCGTGAATGATAAGATAGTTGCGCATAATGTGGGAAGTGCTCCTT
TGTCAGCGTATGATAAAATTGGATTCAACCAAAAGAATATGAAAGATTATTCTGATTCGTTCAAGTTTTCCACCAGGTTG
AGCAATGCCGTAAAAGACATTAAGTCTGGCTTTGTGCAATTTTTAACCAATATATTTTCTATGGGATCTTACAGCTTGAT
GAAAGCAAGTGTGGAACATGGAGTCAAAAATACTAATACAAAAGGTGGTTTCCAAAAATCTTAA

Protein sequence : 
MTNEAINQQPQTEAAFNPQQFINNLQVAFIKVDNVVASFDPNQKPIVDKNDRDNRQAFEKISQLREEFANKAIKNPTKKN
QYFSSFISKSNDLIDKDNLIDTGSSIKSFQKFGTQRYQIFMNWVSHQNDPSKINTQKIRGFMENIIQPPISDDKEKAEFL
RSAKQAFAGIIIGNQIRSDQKFMGVFDESLKERQEAEKNGEPNGDPTGGDWLDIFLSFVFNKKQSSDLKETLNQEPVPHV
QPDVATTTTDIQSLPPEARDLLDERGNFSKFTLGDMNMLDVEGVADIDPNYKFNQLLIHNNALSSVLMGSHNGIEPEKVS
LLYGNNGGPEARHDWNATVGYKNQRGDNVATLINVHMKNGSGLVIAGGEKGINNPSFYLYKEDQLTGSQRALSQEEIQNK
VDFMEFLAQNNAKLDNLSKKEKEKFQNEIEDFQKDSKAYLDALGNDHIAFVSKKDKKHLALVAEFGNGELSYTLKDYGKK
ADKALDREAKTTLQGSLKHDGVMFVDYSNFKYTNASKSPDKGVGATNGVSHLEAGFSKVAVFNLPNLNNLAITSVVRQDL
EDKLIAKGLSPQEANKLVKDFLSSNKELVGKALNFNKAVAEAKNTGNYDEVKQAQKDLEKSLKKRERLEKDVAKNLESKS
GNKNKMEAKSQANSQKDEIFALINKEANRDARAIAYAQNLKGIKRELSDKLENINKDLKDFSKSFDEFKNGKNKDFSKAE
ETLKALKGSVKDLGINPEWISKVENLNAALNEFKNGKNKDFSKVTQAKSDLENSIKDVIINQKITDKVDNLNQAVSVAKA
TGDFSGVEQALADLKNFSKEQLAQQAQKNEDFNTGKNSALYQSVKNGVNGTLVGNGLSKAEATTLSKNFSDIKKELNAKL
GNFNNNNNNGLENSTEPIYTQVAKKVKAKIDRLDQIASGLGDVGQAASFLLKRHDKVDDLSKVGLSANHEPIYATIDDLG
GPFPLKRHDKVDDLSKVGLSREQKLTQKIDNLNQAVSEAKASHFDNLDQMIDKLKDSTKKNVVNLYVESAKKVPTSLSAK
LDNYATNSHTRINSNVKNGTINEKATGMLTQKNSEWLKLVNDKIVAHNVGSAPLSAYDKIGFNQKNMKDYSDSFKFSTRL
SNAVKDIKSGFVQFLTNIFSMGSYSLMKASVEHGVKNTNTKGGFQKS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
cagA NP_223213.1 cag island protein, cytotoxicity associated immunodominant antigen Virulence cag PAI Protein 0.0 100
cagA BAD51753.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 89
cagA BAD51750.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 89
cagA AGC69806.1 cag pathogenicity island protein A Virulence cag PAI Protein 0.0 89
cagA YP_003728762.1 cytotoxin-associated protein A Virulence cag PAI Protein 0.0 89
cagA AAR03909.1 CagA Virulence cag PAI Protein 0.0 88
cagA BAD51756.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 88
cagA BAD51760.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 88
cagA BAD51758.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 88
cagA BAD51766.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 88
cagA AAR03881.1 CagA Virulence cag PAI Protein 0.0 88
cagA BAD51759.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 87
cagA BAD51751.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 87
cagA BAD51761.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 87
cagA AAR03939.1 CagA Virulence cag PAI Protein 0.0 87
HP0547 BAD14045.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 86
cagA BAD51752.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 86
cagA AAF17598.1 CagA Virulence cag PAI Protein 0.0 86
HP0547 NP_207343.1 cag pathogenicity island protein (cag26) Virulence cag PAI Protein 0.0 85
cagA AAR03970.1 CagA Virulence cag PAI Protein 0.0 85
cagA AAC44706.1 CagA Virulence cag PAI Protein 0.0 84
cagA BAD51764.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 84
cagA BAC10432.1 CagA Virulence cag PAI Protein 0.0 83
HP0547 BAD13990.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 83
cagA BAC10428.1 CagA Virulence cag PAI Protein 0.0 82
HP0547 BAD13908.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 82
cagA BAD51747.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 82
cagA BAC10419.1 CagA Virulence cag PAI Protein 0.0 79
cagA BAC10429.1 CagA Virulence cag PAI Protein 0.0 79
HP0547 BAD13935.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 79
cagA YP_005777288.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 78
cagA BAC10426.1 CagA Virulence cag PAI Protein 0.0 78
cagA BAC10431.1 CagA Virulence cag PAI Protein 0.0 78
cagA YP_005779046.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 78
HP0547 BAD13963.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 78
cagA BAC10435.1 CagA Virulence cag PAI Protein 0.0 78
cagA BAD51749.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 78
cagA YP_005774524.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 78
HP0547 BAD14072.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 78
cagA BAD51744.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 78
cagA BAD51755.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 78
cagA BAC10421.1 CagA Virulence cag PAI Protein 0.0 78
HP0547 BAD13799.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 78
cagA AAF17597.1 CagA Virulence cag PAI Protein 0.0 78
cagA YP_005775747.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 78
cagA BAD51754.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 78
cagA BAD51762.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 78
HP0547 BAD13880.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 78
cagA BAC10433.1 CagA Virulence cag PAI Protein 0.0 78
HP0547 BAD14018.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 78
cagA BAC10420.1 CagA Virulence cag PAI Protein 0.0 77
cagA BAC10430.1 CagA Virulence cag PAI Protein 0.0 69
cagA BAC10423.1 CagA Virulence cag PAI Protein 0.0 68
cagA BAC10422.1 CagA Virulence cag PAI Protein 0.0 68
HP0547 BAD13826.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 68
HP0547 BAD13853.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 67
cagA BAC10427.1 CagA Virulence cag PAI Protein 0.0 67
cagA BAC10424.1 CagA Virulence cag PAI Protein 0.0 67

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
cagA NP_223213.1 cag island protein, cytotoxicity associated immunodominant antigen VFG0306 Protein 0.0 85