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Name : leuS (TP0586) Accession : NP_219024.1 Strain : Treponema pallidum Nichols Genome accession: NC_000919 Putative virulence/resistance : Unknown Product : leucyl-tRNA synthetase Function : - COG functional category : J : Translation, ribosomal structure and biogenesis COG ID : COG0495 EC number : 6.1.1.4 Position : 636980 - 639616 bp Length : 2637 bp Strand : + Note : leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl DNA sequence : ATGGGGTATCCGTTTCGCGCTCTAGAGAAAAAATGGCAGGCCTATTGGCGCGACAAGCGCGTCTTTTGTGTGTCCGAGGA TGAGCGCTTCCCTCCTGAGCGGCGTGCGTACGTGTTGGACATGTTTCCCTATCCTTCAGCGCAGGGACTTCACGTCGGAC ATCCAGAAGGCTACACTGCAACTGATATTTACTGCCGCTACTTGCGCATGGGTGGTTACAACGTGCTCCACCCTATGGGT TTTGATGCCTTCGGACTTCCGGCAGAAAACTTTGCACTCAAAACTGGTACTCATCCGCGCGTCTCCACCTCCGCCAACTG CGACACCTTTCGCAGACAGATCCAGTCGTTTGGTTTTTCCTACGATTGGGAACGTGAAATATCTACCGCAGATCCAGAAT ACTATCGCTGGACTCAGTGGCTGTTCCTCAAACTTTATGAAAAAGGATTAGCCTATGAAGCAACCGCGCCCATCAATTGG TGTCCCAGCTGCAAAACAGGCCTTGCAAACGAAGAAGTAAGAGACGCGTGCTGCGAGCGCTGTGGTGCTGAGGTGACGCG GCGTGGTGTCCGCCAGTGGATGGTGCGTATTACAGCGTATGCCGAGCGTCTCCTTTCAGATTTAGATGAACTTGACTGGC CTGAGTCAGTTAAACAAATGCAGCGTAATTGGATTGGAAAAAGCTGCGGCGCGGAAATTGACTTTCCCGTAGATGCGCCT GCGTGTTCAGTGCACGATAAGCTACCACAGACAATTCGCGTGTACACCACGCGTGCGGACACGCTTTTTGGAGTAACGTA CCTGGTACTTGCTCCCGAGCATGAAGCGGTAACGGCGCTCACTACACACGCACAACGCGCAGCGGTACAGGCGTACGTGC AACGTGCAGCAAAAAAGAACGATCTCGAACGCACTGATTTAGCGAAGGAAAAGACCGGTGTTTTCACCGGCGCGTACGTG CGCAATCCAATCAATGATATGCGCATACCGGTGTGGGTAGGTGATTATGTGCTCGTTTCCTACGGCACGGGGGCAGTGAT GGCAGTTCCTGCACATGATCAGCGCGACTGGGATTTTGCCACTCGGTTTGGCTTACCCAAGTTAACCGTGGTGTCTGCAG ACTACACTGCAACAGTTCCTAATAGCAACTCCCCTCAAGGCGCGGTACTCCAAAGATGCGTCTCAGACGAGGGTTTTGTC GTCAACTCTGGAGCTTTCAATGGTCTTGCTAGTGCCGACGCGCGAGAACGTATTGTTGCCCATCTTGAAATGCGTGGCGC AGGTGCACGGCGCGTCACCTATCGCCTACGCGACTGGGTGTTCAGCCGTCAGCGCTATTGGGGAGAACCCATCCCTCTTG TGCACTGTCCTTCCTGCGGTGTTGTACCTCTCCCTGAGAGTGCGCTGCCGCTTTTGTTACCCGAAACCGCCGATTTCACT CCCACGGAAGATGGGCAGGGCCCCCTTGCACGAGCGCGCACGTGGCTGCGCGTTCCCTGTCCGCAGTGTGCATCTGACGC AGTGCGAGAAACAAACACAATGCCCCAGTGGGCAGGATCCTGCTGGTATTACCTCCGTTATATGGACCCCCGCAATAAGA CTGCCTTTTGTGCACCCGAGAAGGAGCGTTACTGGGCGCCAGTGGCGTTATATGTAGGTGGTGCAGAGCACGCCGTACTG CATTTACTGTATGCACGCTTTTGGCACAAGGTATTGTACGACTTAGGTCTTGTAAGCACGAAAGAGCCCTTTGCGCGGTT GGTGAACCAAGGCATGATTACGTCGTATGCATATCGCAGGAAAAATGGCGCGCTTGTACCTCACGACGAGGTGCACACTA ATGCTCAAGGTACCTACGTGCATGCTCGTACGGGGGAAAAACTCGAGTGCGTTGTGGCAAAAATGTCAAAAGCGTTAAAG AATGTCGTCAATCCTGATGACATGATTGCAGCGTACGGTGCTGACGCGTGCCGGGTATACGAGATGTTCATGGGACCTCT TGAGGCTTCCAAACCGTGGAATACGCAGGGGTTAGTGGGGGTTTTTCGGTTTTTAGAAAAAATTTGGGTACTTGCGGGGC GCGTGGCGGCCGCAAACGGTATTCCACAAGACTCTCGTGCAGAGCCGCCAGGTGACCTGCACGCACAGAAAAAGTCTTGC AGCATGTACGCCCTCGAAACGCTGTTACACCGGACTATTCAAAAAGTGACCGACGATACGTCGGCGCTTAGTTTTAACAC GGCAATCAGTCAGATGATGATATTTGTAAATGAGGCTACGCGGGTGGCGCGGAGGATGCCTCTTCCCTCTAAAATGTGGG AGATGTTTGTAAAAATCCTCTCTCCCTATGCACCACATTTGGCAGAAGAACTCTGGGAAATGTGTGGGCACACGCACACT ATCGCATATGAGCCTTGGCCACAGGTGGACCCTGCGCGTGTGGCGCCGCATGTGTGCTCCGTAGTGGTGCAGGTGAACGG TAAAGTGCGCGACACCTTCTCCGTAGCGCCGAACGCTCCAAATGAGGAACTCGAGCAAAAGGCGCGGGAAACCGCCGGTG CGCGTAAGTTTCTTGGTACGCAGCAGCCAAAGCGCGTAGTGATAGTTCCCAATAAATTAGTAAATTTCGTTCTGTAG Protein sequence : MGYPFRALEKKWQAYWRDKRVFCVSEDERFPPERRAYVLDMFPYPSAQGLHVGHPEGYTATDIYCRYLRMGGYNVLHPMG FDAFGLPAENFALKTGTHPRVSTSANCDTFRRQIQSFGFSYDWEREISTADPEYYRWTQWLFLKLYEKGLAYEATAPINW CPSCKTGLANEEVRDACCERCGAEVTRRGVRQWMVRITAYAERLLSDLDELDWPESVKQMQRNWIGKSCGAEIDFPVDAP ACSVHDKLPQTIRVYTTRADTLFGVTYLVLAPEHEAVTALTTHAQRAAVQAYVQRAAKKNDLERTDLAKEKTGVFTGAYV RNPINDMRIPVWVGDYVLVSYGTGAVMAVPAHDQRDWDFATRFGLPKLTVVSADYTATVPNSNSPQGAVLQRCVSDEGFV VNSGAFNGLASADARERIVAHLEMRGAGARRVTYRLRDWVFSRQRYWGEPIPLVHCPSCGVVPLPESALPLLLPETADFT PTEDGQGPLARARTWLRVPCPQCASDAVRETNTMPQWAGSCWYYLRYMDPRNKTAFCAPEKERYWAPVALYVGGAEHAVL HLLYARFWHKVLYDLGLVSTKEPFARLVNQGMITSYAYRRKNGALVPHDEVHTNAQGTYVHARTGEKLECVVAKMSKALK NVVNPDDMIAAYGADACRVYEMFMGPLEASKPWNTQGLVGVFRFLEKIWVLAGRVAAANGIPQDSRAEPPGDLHAQKKSC SMYALETLLHRTIQKVTDDTSALSFNTAISQMMIFVNEATRVARRMPLPSKMWEMFVKILSPYAPHLAEELWEMCGHTHT IAYEPWPQVDPARVAPHVCSVVVQVNGKVRDTFSVAPNAPNEELEQKARETAGARKFLGTQQPKRVVIVPNKLVNFVL |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| leuS | YP_281511.2 | leucyl-tRNA synthetase | Not tested | Not named | Protein | 0.0 | 51 |
