Gene Information

Name : smpB (TP0184)
Accession : NP_218623.2
Strain : Treponema pallidum Nichols
Genome accession: NC_000919
Putative virulence/resistance : Unknown
Product : SsrA-binding protein
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0691
EC number : -
Position : 200523 - 200987 bp
Length : 465 bp
Strand : -
Note : binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Ca

DNA sequence :
ATGAGGGGCACAGGAACCCATCTCATTGCAAAGAACCGCAAGGCTTTTTTCAATTACCATGTGGAAGACCGTCTAGAGTG
TGGCATCGCGCTTGAAGGCACGGAGGTGAAGTCTGTGCGCGCGGGGCATCTTTCTTTTCCTGACGCATTTGCAGAGATGC
GCGGAGGCGAGCTGTGGCTAAAGAATGTGCATATTGCGGAGTACGTGCATGCTTGCTCCTTTGCCCCCAATCCGGATCGG
ATGCGGAAGTTACTGGCACATCGGGACCAGATTGCGCGCTTGAAGCGCAAGGTTGAAGAGAAAGGCTATACTCTGGTCCC
CCTGGAGTTTTACCTAAAAGCAGGGCGGGTGAAGGTAGCGCTGGGAATCTGCAAGGGCAAGAAGCTTTTTGACAAGCGCG
CGCAGATCAAAGCTCGCGACAACGCACGGGAGCTGTCCCGCAGCCTCTGTGAGCGACACCACTAG

Protein sequence :
MRGTGTHLIAKNRKAFFNYHVEDRLECGIALEGTEVKSVRAGHLSFPDAFAEMRGGELWLKNVHIAEYVHACSFAPNPDR
MRKLLAHRDQIARLKRKVEEKGYTLVPLEFYLKAGRVKVALGICKGKKLFDKRAQIKARDNARELSRSLCERHH

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
smpB YP_001800894.1 SsrA-binding protein Not tested Not named Protein 1e-29 47
unnamed AET14351.1 SsrA-binding protein Not tested SaPI68111 Protein 3e-28 44