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Name : ureB (HP0072) Accession : NP_206872.1 Strain : Helicobacter pylori 26695 Genome accession: NC_000915 Putative virulence/resistance : Virulence Product : urease subunit beta Function : - COG functional category : E : Amino acid transport and metabolism COG ID : COG0804 EC number : 3.5.1.5 Position : 75527 - 77236 bp Length : 1710 bp Strand : - Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureA(alph DNA sequence : ATGAAAAAGATTAGCAGAAAAGAATATGTTTCTATGTATGGCCCTACTACAGGCGATAAAGTGAGATTGGGCGATACAGA CTTGATCGCTGAAGTAGAACATGACTACACCATTTATGGCGAAGAGCTTAAATTCGGTGGCGGTAAAACCCTGAGAGAAG GCATGAGCCAATCCAACAACCCTAGCAAAGAAGAATTGGATCTAATCATCACTAACGCTTTAATCGTGGATTACACCGGT ATTTATAAAGCGGATATTGGTATTAAAGATGGCAAAATCGCTGGCATTGGTAAAGGCGGTAACAAAGACATGCAAGATGG CGTTAAAAACAATCTTAGCGTAGGTCCTGCTACTGAAGCCTTAGCCGGTGAAGGTTTGATCGTAACTGCTGGTGGTATTG ACACACACATCCACTTCATTTCACCCCAACAAATCCCTACAGCTTTTGCAAGCGGTGTAACAACCATGATTGGTGGCGGA ACTGGTCCTGCTGATGGCACTAATGCGACTACTATCACTCCAGGCAGAAGAAATTTAAAATGGATGCTCAGAGCGGCTGA AGAATATTCTATGAACTTAGGTTTCTTGGCTAAAGGTAACGCTTCTAACGACGCGAGCTTAGCCGATCAAATTGAAGCTG GTGCGATTGGCTTTAAAATCCACGAAGACTGGGGCACCACTCCTTCTGCAATCAATCATGCGTTAGATGTTGCAGACAAA TACGATGTGCAAGTCGCTATCCACACAGACACTTTGAATGAAGCCGGTTGCGTGGAAGACACTATGGCAGCTATTGCCGG ACGCACTATGCACACTTTCCACACTGAAGGTGCTGGCGGCGGACACGCTCCTGATATTATTAAAGTAGCTGGTGAACACA ACATTCTTCCCGCTTCCACTAACCCCACTATCCCTTTCACTGTGAATACAGAAGCAGAACACATGGACATGCTTATGGTG TGCCACCACTTGGATAAAAGCATTAAAGAAGATGTTCAGTTCGCTGATTCAAGGATCCGCCCTCAAACCATTGCGGCTGA AGACACTTTGCATGACATGGGGATTTTCTCAATCACCAGCTCTGACTCTCAAGCTATGGGTCGTGTGGGTGAAGTTATCA CTAGAACTTGGCAAACAGCTGACAAAAACAAAAAAGAATTTGGCCGCTTGAAAGAAGAAAAAGGCGATAACGACAACTTC AGGATCAAACGCTACTTGTCTAAATACACCATTAACCCAGCGATCGCTCATGGGATTAGCGAGTATGTAGGTTCTGTAGA AGTGGGCAAAGTGGCTGACTTGGTATTGTGGAGTCCCGCATTCTTTGGCGTAAAACCCAACATGATCATCAAAGGCGGGT TCATTGCGTTGAGTCAAATGGGTGACGCGAACGCTTCTATCCCTACCCCACAACCAGTTTATTACAGAGAAATGTTCGCT CATCATGGTAAAGCCAAATACGATGCAAACATCACTTTTGTGTCTCAAGCGGCTTATGACAAAGGCATTAAAGAAGAATT AGGGCTTGAAAGACAAGTGTTGCCGGTAAAAAATTGCAGAAACATCACTAAAAAAGACATGCAATTCAACGACACTACCG CTCACATTGAAGTCAATCCTGAAACTTACCATGTGTTCGTGGATGGCAAAGAAGTAACTTCTAAACCAGCCAATAAAGTG AGCTTGGCGCAACTCTTTAGCATTTTCTAG Protein sequence : MKKISRKEYVSMYGPTTGDKVRLGDTDLIAEVEHDYTIYGEELKFGGGKTLREGMSQSNNPSKEELDLIITNALIVDYTG IYKADIGIKDGKIAGIGKGGNKDMQDGVKNNLSVGPATEALAGEGLIVTAGGIDTHIHFISPQQIPTAFASGVTTMIGGG TGPADGTNATTITPGRRNLKWMLRAAEEYSMNLGFLAKGNASNDASLADQIEAGAIGFKIHEDWGTTPSAINHALDVADK YDVQVAIHTDTLNEAGCVEDTMAAIAGRTMHTFHTEGAGGGHAPDIIKVAGEHNILPASTNPTIPFTVNTEAEHMDMLMV CHHLDKSIKEDVQFADSRIRPQTIAAEDTLHDMGIFSITSSDSQAMGRVGEVITRTWQTADKNKKEFGRLKEEKGDNDNF RIKRYLSKYTINPAIAHGISEYVGSVEVGKVADLVLWSPAFFGVKPNMIIKGGFIALSQMGDANASIPTPQPVYYREMFA HHGKAKYDANITFVSQAAYDKGIKEELGLERQVLPVKNCRNITKKDMQFNDTTAHIEVNPETYHVFVDGKEVTSKPANKV SLAQLFSIF |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| ureC | NP_286680.1 | urease subunit alpha | Virulence | TAI | Protein | 4e-157 | 62 |
| ureC | NP_287088.1 | urease subunit alpha | Not tested | TAI | Protein | 4e-157 | 62 |
| ureC | YP_005684266.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 2e-146 | 60 |
| ureC | YP_005682174.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 3e-146 | 60 |
| ureC | YP_003784325.1 | urease subunit alpha | Not tested | PiCp 7 | Protein | 3e-146 | 60 |
| ureC | YP_005686358.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 3e-146 | 60 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| ureB | NP_206872.1 | urease subunit beta | VFG0270 | Protein | 0.0 | 100 |
