Gene Information

Name : HP0106 (HP0106)
Accession : NP_206906.1
Strain : Helicobacter pylori 26695
Genome accession: NC_000915
Putative virulence/resistance : Resistance
Product : cystathionine gamma-synthase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 2.5.1.48
Position : 113333 - 114475 bp
Length : 1143 bp
Strand : -
Note : catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine and L-cysteine; or Cystathionine beta-lyase (CBL) can convert cystathionine to homocysteine

DNA sequence :
ATGCGCATGCAAACCAAATTAATCCATGGGGGCATTAGTGAGGACGCAACAACGGGGGCGGTGAGCGTGCCTATTTATCA
AACTTCCACCTACCGCCAAGACGCCATAGGCCGCCATAAGGGCTATGAATACTCTCGCTCAGGCAACCCCACGCGCTTTG
CTTTAGAAGAACTCATCGCTGATTTAGAAGGGGGGGTTAAGGGGTTTGCTTTTGCCTCTGGATTAGCTGGAATCCACGCC
GTTTTTTCCCTCTTGCAATCAGGCGATCATGTGTTATTGGGCGATGATGTTTATGGGGGGACTTTCCGCTTGTTTAATCA
AGTGCTTGTCAAAAACGGGCTTTCTTGCACCATTATAGACACTAGCGATATATCCCAAATTAAAAAGGCTATCAAGCCCA
ACACCAAAGCCCTTTATTTAGAAACCCCTAGTAACCCCTTGCTTAAAATCACGGATTTAGCGCAATGCGCTAGTGTCGCT
AAAGATCATGGTTTGCTCACTATCGTGGATAACACCTTTGCCACCCCCTATTATCAAAACCCGCTTCTTTTGGGAGCGGA
CATTGTGGCACATAGCGGCACCAAATACTTAGGCGGGCATAGCGATGTGGTCGCCGGGCTTGTAACCACTAATAATGAAG
CGCTAGCCCAAGAGATCGCTTTTTTCCAAAACGCTATCGGTGGGGTTTTAGGCCCTCAAGACAGCTGGCTGTTGCAAAGA
GGGATTAAAACGCTGGGATTGCGCATGGAAGCCCATCAAAAAAACGCTCTTTGTGTGGCTGAGTTTTTAGAAAAACACCC
TAAAGTGGAAAGGGTTTATTACCCGGGCCTTCCCACTCACCCTAATTACGAACTAGCTAAAAAACAGATGCGTGGCTTTA
GCGGGATGCTCTCTTTCACTCTCAAAAATGATAGCGAGGCGGTTGCTTTTGTAGAAAGCCTTAAACTATTCATTTTAGGC
GAGAGTTTGGGCGGGGTGGAAAGTTTGGTGGGGATTCCGGCATTTATGACCCATGCGTGCATCCCTAAAACGCAACGAGA
AGCTGCTGGGATTAGAGATGGCCTGGTGCGCTTGTCTGTAGGGATTGAGCATGAACAGGATTTGTTAGAAGATTTAGAGC
AAGCGTTCGCTAAAATAGGCTAA

Protein sequence :
MRMQTKLIHGGISEDATTGAVSVPIYQTSTYRQDAIGRHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHA
VFSLLQSGDHVLLGDDVYGGTFRLFNQVLVKNGLSCTIIDTSDISQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVA
KDHGLLTIVDNTFATPYYQNPLLLGADIVAHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQR
GIKTLGLRMEAHQKNALCVAEFLEKHPKVERVYYPGLPTHPNYELAKKQMRGFSGMLSFTLKNDSEAVAFVESLKLFILG
ESLGGVESLVGIPAFMTHACIPKTQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFAKIG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 2e-96 54
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 1e-97 54
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 4e-73 47

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
HP0106 NP_206906.1 cystathionine gamma-synthase BAC0207 Protein 2e-63 43