Gene Information

Name : thyA (MG_227)
Accession : NP_072893.1
Strain : Mycoplasma genitalium G37
Genome accession: NC_000908
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 273790 - 274653 bp
Length : 864 bp
Strand : +
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGAAACAGTATTTAGATTTAGCTAGTTATGTTTTAGCAAATGGTAAAAAAAGAAAAAACCGTACAGATACAGATACTTT
AAGTGTCTTTGGTTACCAGATGAAATTTGACCTTACTAATAGTTTTCCTTTATTGACAACTAAAAAGGTTAATTGGAAGG
CAATTGTCCATGAATTGTTGTGATTTATTAAGGGTGATACCAACATTAAGTACTTAGTTGATAATGGGGTGAACATCTGA
AATGAATGACCATATGAAAACTTTAAAAAATCACCAAGTTTTCAAAACGAAACACTCCAAGAATTTATCTTAAAGGTTAA
AACTGATAATGAGTTTGCTAAACAATTTGCTGATTTGGGTCCTGTTTATGGCAAGCAATGACGTAATTTTAATGGTGTTG
ATCAACTCAAAAAAGTCATCCAAGAGATTAAAGAAAATCCCAACTCAAGAAGGCTAATTGTCTCAAGCTGAAACCCTAGT
GAATTGGAAAAAATGGCATTGGCTCCTTGTCATTCACTCTTTCAGTTCTATGTTGAAGAAGATAAACTAAGCTTACAGCT
TTACCAGCGCAGCGGTGATATCTTTCTTGGTGTCCCATTTAACATTGCATCTTACGCCTTACTTGTGTATTTAGTTGCTC
ATGAAACTAAGTTAAAACCTGGTTATTTTATCCATACACTAGGAGATGCACATATCTATGAAAACCACATTGAACAAATT
AAATTACAACTAACAAGAACAACCCTAGACCCCCCTCAAGTGGTTTTGAAAAGTGATAAATCAATCTTTGCTTATAGTTT
TGATGATATTGAGTTAGTTGGTTATAATTACCATCCATTTATCTATGGGAGGGTTGCAGTTTAA

Protein sequence :
MKQYLDLASYVLANGKKRKNRTDTDTLSVFGYQMKFDLTNSFPLLTTKKVNWKAIVHELLWFIKGDTNIKYLVDNGVNIW
NEWPYENFKKSPSFQNETLQEFILKVKTDNEFAKQFADLGPVYGKQWRNFNGVDQLKKVIQEIKENPNSRRLIVSSWNPS
ELEKMALAPCHSLFQFYVEEDKLSLQLYQRSGDIFLGVPFNIASYALLVYLVAHETKLKPGYFIHTLGDAHIYENHIEQI
KLQLTRTTLDPPQVVLKSDKSIFAYSFDDIELVGYNYHPFIYGRVAV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_189147.1 thymidylate synthase Not tested ¥ÕSP¥â Protein 2e-74 52
thyA YP_001800914.1 thymidylate synthase Not tested Not named Protein 1e-62 50