Gene Information

Name : lysS (MG_136)
Accession : NP_072798.1
Strain : Mycoplasma genitalium G37
Genome accession: NC_000908
Putative virulence/resistance : Virulence
Product : lysyl-tRNA synthetase
Function : -
COG functional category : J : Translation, ribosomal structure and biogenesis
COG ID : COG1190
EC number : 6.1.1.6
Position : 160963 - 162435 bp
Length : 1473 bp
Strand : +
Note : class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA

DNA sequence :
ATGAGTGATCGTTTAAATGATCAAGCCCAACATCGCTTGCAGAAACTTTTAAGGTTAAAACAAACTAATAATGACCCTTA
TTTAGTAACAAAAACTAGTCTAACCCATTCTTCAAAAAGCTTTCAAGTTGAATTTGAAAAATGTTCAGAAGAAGAGTTGA
AGAAAAAAGCAACTGTCTCACTAGCTGGAAGGATCATTGCTATTAGACAAACCTTTTTAATTATTCAAGATTTTGATGGT
CAAGTCCAACTTTACATCAATAAAAAAATCCATCCTAAGTTATTTGATTACTTTAATGAATTTGTTGATATTGGTGATCA
AATTGTTGTTAGTGGTAAGCCAATGTTAACTAAAACAAAGGTATTAACTTTAGCTGTTGAAGAGATGAAAATCATTGCTA
AGTGTTTATTGGTTCCACCTGAAAAGTGACATGGACTTACTGATATTGAAACCCGCGCTCGCAAGCGCTTTCTTGATCTT
ACCTATAACTTAGCAATGCGTGATGTTTTTCTGAAACGCACTAAGATTATTAAATCAATCCGTAGCTTTCTTGATCAAAA
TGGTTTTATTGAAGTTGAAACCCCCACTTTACAAGCTGTTTTAGGAGGAGCTAATGCTAAACCCTTTAAAACCCATTACA
ATGCTTTAAAAGCGGATTTTTATCTCAGAATTGCTAATGAAATAGCATTAAAAAAACTCATTATTGGTGGATTTAACAAG
GTTTATGAAATGGGTAAAATGTTCCGTAATGAAGGGGTTGATACTACCCACAATCCTGAGTTTACCAGTATTGAAATATA
TCAAGCTTATGCAGATTTTGAAGTCATGCTTGTGCTTGTTGAAAAGCTGATTCAATCACTTTGTGAAAGCTTAAACCAAT
TTAGCTTTAACTGAAATAACAAAACGATTAATCTAAAAACACCATTTCATAAGATAACAATGGTTGAACTTATTAAGAAA
GTTACAGGGATCGATTTTAATTCAGTAAAAGATGATCAATCTGCCATTTTATTAGCAGAAAAACATCATGTTAAACTAGC
AAAACACCAACAAAATAAGCAACACATCATTAATTTGTTTTTTGAACAGTTTTGTGAACAAACATTAATTGAACCTACCT
TTGTAACCCATTATCCAAAAGCAGTTTCTCCTTTAGCAAAACAAGATCCTTCAAATCCTGAATTCACCCAACGATTTGAA
CTTTTTATTAATGGTAAAGAGATTGCTAATGCTTACAGTGAGCTAAACGATCCTTTAGAACAAAGAAAAAGGTTTGAACA
ACAACTTGAAGAAAAACAGCTTGGTAATGATGAGACAAGTGAACTTGATGAATCGTTTTTAGAAGCATTAAGTTTTGGGA
TGGTAAACACTGCTGGGCTTGGGATAGGTATTGATCGTTTGGTAATGTTGTTATGTGAATGTAATTCTATCCGTGATGTT
GTTTTCTTCCCCCAGTTGCGTGAACATAAATAG

Protein sequence :
MSDRLNDQAQHRLQKLLRLKQTNNDPYLVTKTSLTHSSKSFQVEFEKCSEEELKKKATVSLAGRIIAIRQTFLIIQDFDG
QVQLYINKKIHPKLFDYFNEFVDIGDQIVVSGKPMLTKTKVLTLAVEEMKIIAKCLLVPPEKWHGLTDIETRARKRFLDL
TYNLAMRDVFLKRTKIIKSIRSFLDQNGFIEVETPTLQAVLGGANAKPFKTHYNALKADFYLRIANEIALKKLIIGGFNK
VYEMGKMFRNEGVDTTHNPEFTSIEIYQAYADFEVMLVLVEKLIQSLCESLNQFSFNWNNKTINLKTPFHKITMVELIKK
VTGIDFNSVKDDQSAILLAEKHHVKLAKHQQNKQHIINLFFEQFCEQTLIEPTFVTHYPKAVSPLAKQDPSNPEFTQRFE
LFINGKEIANAYSELNDPLEQRKRFEQQLEEKQLGNDETSELDESFLEALSFGMVNTAGLGIGIDRLVMLLCECNSIRDV
VFFPQLREHK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
unnamed CAD66193.1 putative lysil-tRNA synthetase LysU Not tested PAI III 536 Protein 6e-81 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
lysS NP_072798.1 lysyl-tRNA synthetase VFG1668 Protein 3e-81 41