Gene Information

Name : guaA (HI0222)
Accession : NP_438394.1
Strain : Haemophilus influenzae Rd KW20
Genome accession: NC_000907
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 251125 - 252696 bp
Length : 1572 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGACAAATATCCACTATCACAAAATCCTAATCCTCGACTTTGGTTCACAATACACTCAACTGATTGCGCGTCGTGTGCG
TGAAATCGGTGTGTACTGCGAACTTTGGGCTTGGGATGTAACCGAACAACAAATCCGTGAATTTGCTCCAACGGGTATCA
TTCTTTCTGGCAGTCCTGAAAGCACAACTGAAGAAAATAGCCCTCGTGCACCGGAATATGTATTTAATGCTGGTGTACCA
GTATTAGGCATTTGCTATGGAATGCAAACGATGGCGATGCAACTTGGCGGCTTAACCGAAACGTCTGATCACAGAGAGTT
CGGCTATGCTTCCGTTTCTCTTGAAAATTCCACCGCACTTTTTGCAAATCTTAACGATAATTTAACCGCTTCTGAGCCAA
AATTAGACGTTTGGATGAGCCACGGCGATAAGGTAACGCGCTTACCAGAAAACTTCAAAGTAACTGGCACAACGCTAACC
TGCCCAATTGCTGCGATGTCTGATGAAAGCCGTCGTTTCTACGGTGTGCAGTTCCACCCTGAAGTAACGCATACTAAAAA
AGGCTTGGAATTATTAACCAACTTCGTAGTAAACATCTGTGGTTGCGAAACCAAATGGACAGCAGAAAACATTATCGAAG
ATGCCGTTGCTCGCATTAAAGAGCAAGTGGGCGATGATGAAGTGATTTTAGGCTTATCTGGTGGTGTGGACTCTTCTGTG
GTTGCATTACTTTTACACCGTGCTATCGGCAAAAACTTACACTGCGTATTTGTGGATAACGGTTTACTCCGCTTACACGA
AGGCGACCAAGTCATGGAAATGTTTGGCGATAAATTCGGTTTAAACATCACTCGTGTTGATGCTGAAAGTCGTTTCTTAG
GTGAACTTGCAGGCGTATCTGATCCTGAAGCGAAACGTAAAATTATCGGTAAAGTGTTCGTGGATGTATTCGATGATGAA
TCGAAAAAACTCACTAATGTGAAATGGTTGGCACAAGGTACGATTTACCCTGACGTAATCGAATCTGCAGCAAGCAAAAC
TGGTAAAGCACATGTGATTAAATCACACCACAACGTAGGTGGCTTACCAGACTATATGAAACTTGGTTTAGTTGAACCTT
TACGTGAATTATTTAAAGATGAAGTACGTAAAATCGGTTTAGCATTAGGCTTACCAGCTGAAATGATCAACCGCCACCCA
TTCCCTGGCCCAGGCTTAGGTGTGCGTGTATTAGGCGAAGTGAAAAAAGAATACTGCGATTTATTACGCCGTGCGGATGC
GATCTTTATCGAAGAATTACGCAACAGCGGTTGGTATGAAAAAACCAGCCAAGCCTTCAGCGTATTCTTACCAGTGAAAT
CTGTAGGTGTGATGGGCGATGGCCGTAAATACGATTGGGTTATTTCCCTACGCGCGGTAGAAACAATCGATTTTATGACC
GCACATTGGGCACATTTGCCTTATGATTTATTAGGCAAAGTGTCTAACCGTATCATCAACGAAGTGAATGGAATTTCCCG
CGTCGTATACGACATCAGCGGAAAACCACCCGCAACAATCGAGTGGGAATAA

Protein sequence :
MTNIHYHKILILDFGSQYTQLIARRVREIGVYCELWAWDVTEQQIREFAPTGIILSGSPESTTEENSPRAPEYVFNAGVP
VLGICYGMQTMAMQLGGLTETSDHREFGYASVSLENSTALFANLNDNLTASEPKLDVWMSHGDKVTRLPENFKVTGTTLT
CPIAAMSDESRRFYGVQFHPEVTHTKKGLELLTNFVVNICGCETKWTAENIIEDAVARIKEQVGDDEVILGLSGGVDSSV
VALLLHRAIGKNLHCVFVDNGLLRLHEGDQVMEMFGDKFGLNITRVDAESRFLGELAGVSDPEAKRKIIGKVFVDVFDDE
SKKLTNVKWLAQGTIYPDVIESAASKTGKAHVIKSHHNVGGLPDYMKLGLVEPLRELFKDEVRKIGLALGLPAEMINRHP
FPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELRNSGWYEKTSQAFSVFLPVKSVGVMGDGRKYDWVISLRAVETIDFMT
AHWAHLPYDLLGKVSNRIINEVNGISRVVYDISGKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 9e-130 54
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 8e-130 54
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 7e-130 54
guaA NP_938969.1 GMP synthase Not tested Not named Protein 1e-109 48