Gene Information

Name : alr (HI1575)
Accession : NP_439721.1
Strain : Haemophilus influenzae Rd KW20
Genome accession: NC_000907
Putative virulence/resistance : Unknown
Product : alanine racemase
Function : -
COG functional category : M : Cell wall/membrane/envelope biogenesis
COG ID : COG0787
EC number : 5.1.1.1
Position : 1643226 - 1644308 bp
Length : 1083 bp
Strand : +
Note : converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer

DNA sequence :
ATGAACGTAAAACCGGCGACAGCGAAAATTAGTTCGCACGCCTTAAAACAGAATTTAGAAATAATTAAACAAAAAGCACC
AAATAGCAAAATTATTGCTGTGGTTAAAGCAAACGCCTATGGTCACGGCGTTGTATTCGTTGCTTCAACCTTAGAACAAA
ATGTTGATTGCTTTGGCGTGGCGCGTTTAGAAGAGGCTTTAGCATTACGCTCCAACGGCATTACTAAACCGATTTTATTG
CTTGAAGGTTTTTTCAATGAACAAGATTTGCCTATTCTAGCCGTTAATAATATTGAAACCGTGGTACACAATCACGAACA
GCTTGATGCTTTAAAACGTGCGAATTTACCAAGTCCAATTAAGGTTTGGTTAAAAATAGATACGGGAATGCATCGCTTGG
GCGTTGCTCTTGATGAAGTGGATTATTTTTATCAAGAACTGAAAAAACTCCCTCAAATTCAACCGCACTTAGGCTTTGTC
AGCCATTTCAGCCGAGCCGATGAACTAGAATCAGATTACACCCAACTTCAAATCAATCGTTTTTTATCCGTCACAAAAGA
TAAACAAGGTGAACGTACTATTGCAGCGTCAGGCGGCATTCTTTTCTGGCCAAAATCCCACTTAGAATGTATCCGCCCAG
GCATTATTATGTACGGCATTTCTCCAACTGATACTATCGGTAAAGAGTTTGGCTTAACGCCAGTGATGAATTTAACCTCG
TCATTAATTGCCGTTCGCCATCATAAACAAGGCGATCCTGTAGGTTACGGCGGTATTTGGACAAGTCCACGAGATACCAA
AATTGGAGTGGTCGCAATGGGTTATGGCGATGGTTATCCGCGCGATGTGCCAGAAGGTACACCTGTTTATTTAAATGGCC
GTCTTGTACCAATTGTTGGACGTGTGTCAATGGATATGCTTACTGTTGATTTAGGCGCAGATAGCCAAGATTTGGTAGGC
GATGAAGTAATTTTATGGGGCAAGGAATTACCTATTGAAACCGTAGCTAAATTCACAGGCATTTTAAGCTACGAGCTAAT
TACAAAATTAACACCTCGTGTTATAACTGAATACGTTGATTAA

Protein sequence :
MNVKPATAKISSHALKQNLEIIKQKAPNSKIIAVVKANAYGHGVVFVASTLEQNVDCFGVARLEEALALRSNGITKPILL
LEGFFNEQDLPILAVNNIETVVHNHEQLDALKRANLPSPIKVWLKIDTGMHRLGVALDEVDYFYQELKKLPQIQPHLGFV
SHFSRADELESDYTQLQINRFLSVTKDKQGERTIAASGGILFWPKSHLECIRPGIIMYGISPTDTIGKEFGLTPVMNLTS
SLIAVRHHKQGDPVGYGGIWTSPRDTKIGVVAMGYGDGYPRDVPEGTPVYLNGRLVPIVGRVSMDMLTVDLGADSQDLVG
DEVILWGKELPIETVAKFTGILSYELITKLTPRVITEYVD

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
dadX AAC61705.1 alanine racemase Not tested PAI I CFT073 Protein 3e-59 42