Gene Information

Name : pykA (HI1573)
Accession : NP_439719.1
Strain : Haemophilus influenzae Rd KW20
Genome accession: NC_000907
Putative virulence/resistance : Virulence
Product : pyruvate kinase
Function : -
COG functional category : G : Carbohydrate transport and metabolism
COG ID : COG0469
EC number : 2.7.1.40
Position : 1640232 - 1641668 bp
Length : 1437 bp
Strand : +
Note : catalyzes the formation of phosphoenolpyruvate from pyruvate

DNA sequence : 
ATGTCTAGAAGACTAAGAAGAACGAAGATTGTATGTACTATGGGCCCATCAACTGACCGTGATAACAATCTTGAAAAAAT
TATCGCAGCGGGCGCAAACGTAGTTCGTATGAACTTCTCTCACGGTACACCTGATGACCATATCGGACGTGCTGAACGTG
TACGTTCTATTGCGAAAAAATTAGGTAAAACCGTGGCAATCTTAGGTGATTTACAAGGTCCTAAAATTCGTGTTTCTACT
TTTAAAGACGGTAAAATTTTCTTAAACGTTGGCGATAAATTCATTCTTGATGCAGAGTTACCAAAAGGCGAAGGCACTCA
AGAATCCGTTGGTTTAGACTATAAAACGCTTCCTCAAGATGTTGTGCCGGGCGATATTCTTTTATTAGATGATGGCCGTG
TTCAATTAAAAGTATTATCAACTGATGGTGCAAAAGTTTTCACTGAAGTTACTGTTGGTGGTCCATTATCAAATAATAAA
GGTATCAATAAATTAGGTGGCGGTTTATCTGCGGATGCCCTAACAGAAAAAGATAAAGCCGACATTATTACCGCTGCACG
CATTGGTGTTGATTTCTTAGCCGTTTCTTTCCCTCGTTCAAGTGCAGATTTAAATTATGCACGTGAACTTGCTCAACAAG
CAGGTTTAAATGCAAAAATCGTTGCTAAAGTTGAACGTGCAGAAACCGTTGCTAATGATGAAGCCATGGACGATATTATT
TTAGCCTCTGATGTAATTATGGTTGCACGTGGTGACTTAGGTGTAGAAATCGGCGATCCTGAATTAGTCGGTGTACAGAA
AAAATTAATCCGTCGTTCACGTCAATTAAATCGTGCTGTAATTACAGCGACTCAAATGATGGAATCAATGATTAGTAACC
CAATGCCAACTCGTGCTGAAGTAATGGACGTTGCAAACGCAGTATTAGATGGAACTGATGCAGTTATGCTTTCTGCAGAA
ACAGCAGCTGGTCAATATCCTTCTGAAACAGTGGCAGCAATGGCTAGCGTATGTTTAGGTGCAGAAAAAATGCCAAGCAT
TAACGTTTCTCGTCACCGTATGGATAAAGAATTTGAAACTATTGAAGAATCTGTTGCGATGTCTGCAATGTATGCAGCAA
ACCACATGAAAGGTGTAGCGGCAATCGTCACTTTAAGTAGCACAGGCCGTACTCCATTATTAATGTCACGCATTAGCTCT
GGCTTACCAATCTTTGCTTTATCTCGTAATCAAGAAACCCTAAACCTTTGTGCACTATACCGCGGTGTAACACCAATTTA
TCACGGCGAAGAAAGTCGTACAGAAGCTGGTGCAAAAGCAGCACCTCAATCATTAAAAGAAAAAGGTTATTTATCTACTG
GCGATTTAGTGCTGGTAACCCAAGGTGGTCAAGGTGCGACACAAACTAACGTATGTCGTACATTAATTGTTGAATAA

Protein sequence : 
MSRRLRRTKIVCTMGPSTDRDNNLEKIIAAGANVVRMNFSHGTPDDHIGRAERVRSIAKKLGKTVAILGDLQGPKIRVST
FKDGKIFLNVGDKFILDAELPKGEGTQESVGLDYKTLPQDVVPGDILLLDDGRVQLKVLSTDGAKVFTEVTVGGPLSNNK
GINKLGGGLSADALTEKDKADIITAARIGVDFLAVSFPRSSADLNYARELAQQAGLNAKIVAKVERAETVANDEAMDDII
LASDVIMVARGDLGVEIGDPELVGVQKKLIRRSRQLNRAVITATQMMESMISNPMPTRAEVMDVANAVLDGTDAVMLSAE
TAAGQYPSETVAAMASVCLGAEKMPSINVSRHRMDKEFETIEESVAMSAMYAANHMKGVAAIVTLSSTGRTPLLMSRISS
GLPIFALSRNQETLNLCALYRGVTPIYHGEESRTEAGAKAAPQSLKEKGYLSTGDLVLVTQGGQGATQTNVCRTLIVE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
pykA NP_273151.1 pyruvate kinase Not tested IHT-A Protein 5e-78 49
pykF YP_216386.1 pyruvate kinase Not tested SPI-2 Protein 3e-55 45
pykF NP_805051.1 pyruvate kinase Not tested SPI-2 Protein 3e-55 45
pykF CAA68205.1 pyruvate kinase like protein Not tested SPI-2 Protein 8e-55 45
STY1744 NP_456147.1 pyruvate kinase Not tested SPI-2 Protein 9e-56 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
pykA NP_439719.1 pyruvate kinase VFG0479 Protein 1e-55 45