Gene Information

Name : HI0144 (HI0144)
Accession : NP_438313.1
Strain : Haemophilus influenzae Rd KW20
Genome accession: NC_000907
Putative virulence/resistance : Virulence
Product : N-acetylmannosamine kinase
Function : -
COG functional category : K : Transcription
COG ID : COG1940
EC number : 2.7.1.60
Position : 159574 - 160476 bp
Length : 903 bp
Strand : -
Note : catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein

DNA sequence : 
ATGCGTTGTTTAGCACTAGATATTGGTGGGACAAAAATTGCAGCGGCGATTGTAAAAAATGGCGAAATTGAGCAACGTCA
GCAAATTCATACACCACGTGAAAATGTCGTGGAGGGAATGCACCAAGCGTTAGGCAAATTGCTTGCTGATTATGAAGGGC
AGTTTGATTATGTAGCGGTAGCATCTACGGGGATCATCAATAATGGCATTTTAAGTGCATTAAATCCGAAAAACTTAGGT
GGCTTGGCGGAATTTCCACTTAAAGCGAGTATTGCAAAACATACGGATAAACCGATTGGTTTATTAAATGATGCACAAGC
TGCGACTTATGCGGAATATCAATTGCAAAATTCTGAACAGGTATCAAATTTTGTTTTTATTACCGTTTCAACAGGAGTTG
GCGGAGGGATTGTGCTGAACCAAATTTTGCAGACAGGTTCTCGTGGTATTGCTGGGCATATTGGTCATACATTAGCTGAT
CCAAATGGTGCGATCTGTGGTTGTGGGCGTCGAGGTTGTGTCGAAGCGATTGCTTCAGGGCGAGCAATTGAAGCAGTTTC
TTCCCAATGGGAAGAACCGTGCGATCCAAAAGAAGTGTTTGAGCGTTTTAGAAAAAATGATGAAAAAGCGACCGCACTTG
TCGAGCGTTCTGCGAAAGCCATTGCTAATTTAATTGCTGATTTAGTGATTAGTTTAGATATTCAAAAAATCGCGATTGGT
GGCAGTGTGGGATTAGCTGAGGGATATTTATCTTTGGTTGAAAAATATTTACAAGATTTTCCTTCGATATATTGTTGTGA
AATTGAAACCGCTAAATTTGGACAAGATGCAGGTTTAATTGGCGCAGCTTATTGGGTAAAAGATGTTTTACTGGATAAGC
CTGAAGGAACAATTTATGGCTAA

Protein sequence : 
MRCLALDIGGTKIAAAIVKNGEIEQRQQIHTPRENVVEGMHQALGKLLADYEGQFDYVAVASTGIINNGILSALNPKNLG
GLAEFPLKASIAKHTDKPIGLLNDAQAATYAEYQLQNSEQVSNFVFITVSTGVGGGIVLNQILQTGSRGIAGHIGHTLAD
PNGAICGCGRRGCVEAIASGRAIEAVSSQWEEPCDPKEVFERFRKNDEKATALVERSAKAIANLIADLVISLDIQKIAIG
GSVGLAEGYLSLVEKYLQDFPSIYCCEIETAKFGQDAGLIGAAYWVKDVLLDKPEGTIYG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
nanK YP_002414055.1 N-acetylmannosamine kinase Not tested Not named Protein 2e-38 49
VC1782 NP_231417.1 N-acetylmannosamine kinase Not tested VPI-2 Protein 6e-34 43
VC0395_A1379 YP_001217322.1 N-acetylmannosamine kinase Not tested VPI-2 Protein 6e-34 43

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
HI0144 NP_438313.1 N-acetylmannosamine kinase VFG1115 Protein 2e-34 43