Gene Information

Name : murD (HI1136)
Accession : NP_439294.1
Strain : Haemophilus influenzae Rd KW20
Genome accession: NC_000907
Putative virulence/resistance : Unknown
Product : UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
Function : -
COG functional category : M : Cell wall/membrane/envelope biogenesis
COG ID : COG0771
EC number : 6.3.2.9
Position : 1203734 - 1205047 bp
Length : 1314 bp
Strand : +
Note : UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation

DNA sequence :
ATGAACGCCTATCAAAACAAAAATATTACTATCATCGGGCTTGGCAAAACAGGTCTTTCTTGTGTGGATTATCTCTTATC
CCAACAGGCTAATATTCGTGTGATTGATACTCGAAAAAATCCTACTGGTATTGATAAACTTCCTCAAAATATCCCTCTTC
ATACTGGTAGTTTAAATCAGGAATGGTTACTTGAAAGCGATATGATTGTTATTAGCCCAGGGCTTGCGGTAAAAACACCA
GAAATTCAAACCGCACTTAAAGCGGGAGTGGAAGTAATCGGCGATATTGAATTATTCTGCCGCGCAGCGACAAAGCCAAT
TGTGGGGATTACAGGTTCAAATGGTAAAAGTACCGTAACTACTTTAGTTTATGAAATGGCGAAAGCTGCTGGTGTGAAAG
TTGGTATGGGCGGAAATATTGGGATTCCCGCTTTGTCATTGTTGAATGAAGATTGTGAACTTTATGTACTAGAGCTTTCT
AGTTTTCAGCTTGAGACAACTTATAGCTTAAAAGCTGCGGCAGCGACTGTCTTGAACGTGACTGAAGATCATATGGATCG
CTATATGGATTTAGAAGATTATCGCCAAGCAAAATTACGCATTTATCATAATGCTAAAGTAGGTGTGTTGAACAATGAAG
ATAGGCTGACTTTTGGGGAAAACGAAAATCAAGCGAAACATACCGTTTCTTTTGCGGAAAATAGTGCGGATTATTGGCTA
AAAACTGAAAATGGCAAGCAATATTTAATGGTAAAAGATGAAGTGATTTTACCTTGTGAAGAAGCTACATTGGTTGGTCG
CCATAATTATATGAACATTTTGGCAGCAACAGCATTGGCACAAGCTATAGGTATTAATTTAGATTCAATTCGTACCGCAC
TTCGTCATTTCAAAGGGTTAGATCATCGTTTTCAATTAGTGCATCAAGCTAATGGCATTCGTTGGATTAATGACTCTAAA
GCAACAAATGTGGGGAGTACAGTTGCTGCATTGGCTGGGCTTTATATTGAGGGTAAATTGCATTTGTTGCTAGGCGGAGA
CGGAAAAGGGGCTGATTTTTCAGAATTAGCTGAATTAATTAATCAACCACACATTATTTGTTATTGTTTTGGTCGAGATG
GTGCGCTGCTTGCAAAATTTTCATCGCAAAGTTATTTGTTCGATACAATGGAACAAGCGATAGAATTTTTACGCCCAACA
TTGCAAAGCGGAGATATGGTATTATTGTCGCCTGCTTGTGCAAGTCTCGATCAGTTTGCTTCTTTTGAAAAGCGCGGCGA
AGAATTTACGCATTTAGCTCAATGTTTAACCTAA

Protein sequence :
MNAYQNKNITIIGLGKTGLSCVDYLLSQQANIRVIDTRKNPTGIDKLPQNIPLHTGSLNQEWLLESDMIVISPGLAVKTP
EIQTALKAGVEVIGDIELFCRAATKPIVGITGSNGKSTVTTLVYEMAKAAGVKVGMGGNIGIPALSLLNEDCELYVLELS
SFQLETTYSLKAAAATVLNVTEDHMDRYMDLEDYRQAKLRIYHNAKVGVLNNEDRLTFGENENQAKHTVSFAENSADYWL
KTENGKQYLMVKDEVILPCEEATLVGRHNYMNILAATALAQAIGINLDSIRTALRHFKGLDHRFQLVHQANGIRWINDSK
ATNVGSTVAALAGLYIEGKLHLLLGGDGKGADFSELAELINQPHIICYCFGRDGALLAKFSSQSYLFDTMEQAIEFLRPT
LQSGDMVLLSPACASLDQFASFEKRGEEFTHLAQCLT

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
BJAB0868_00315 YP_008211641.1 UDP-N-acetylmuramoylalanine-D-glutamate ligase Not tested AbaR26 Protein 2e-55 41
BJAB07104_00311 YP_008207776.1 UDP-N-acetylmuramoylalanine-D-glutamate ligase Not tested AbaR25 Protein 2e-55 41